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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.36000061 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.03599548 23.67700005 Tm 0 Tr [(CD)-1(10)1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.5 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.94000244 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CD101)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.77400208 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.27400208 12.82499981 Tm [(    )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 180.27400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CD101)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 111.75700378 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 114.1309967 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 139.78100586 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 142.15499878 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 185.71400452 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 188.08799744 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 225.88400269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD101)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 93.39800262 12.82499981 Tm [(mol)-1(e)1(cul)-1(e;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 135.35699463 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 137.73100281 12.82499981 Tm [(V7;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 151.82000732 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 154.19400024 12.82499981 Tm [(IGSF)-1(2;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 181.2440033 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 183.61799622 12.82499981 Tm [(EWI-101)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 219.91200256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD101)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 113.23400116 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 77 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 156.2749939 0.75 l 156.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 157.2749939 -0.25 l 157.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 157.0249939 172.3500061 l h f* Q q 1 0 0 1 156.6499939 0 cm -0.625 -0.25 m 266.7749939 -0.25 l 266.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Plays)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 21.80599976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 26.30599976 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 31.28100014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 35.78099823 11.72200012 Tm [(role)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 52.44100189 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 56.94100189 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 66.08200073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 70.58200073 11.72200012 Tm [(inhibito)1(r)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 107.11399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 111.61399841 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 120.45600128 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 124.95600128 11.72200012 Tm [(T-ce)-1(lls)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 152.58399963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 157.08399963 11.72200012 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 210.43400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 214.93400574 11.72200012 Tm [(induc)-1(ed)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 249.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 10.51200008 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 15.01200008 27.3220005 Tm [(CD3.)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 35.33200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 39.83200073 27.3220005 Tm [(Inhibit)1(s)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 71.62200165 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 76.12200165 27.3220005 Tm [(expression)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 122.0759964 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 126.5759964 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 135.41799927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 139.91799927 27.3220005 Tm [(IL2)-1(R)1(A)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 164.66799927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 169.16799927 27.3220005 Tm [(on)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 180.43600464 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 184.93600464 27.3220005 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 224.08700562 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 228.58700562 27.3220005 Tm [(T-ce)-1(lls)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 256.21499634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 16.27700043 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 20.77700043 42.92200089 Tm [(sec)-1(retio)1(n)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 60.12099838 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 64.6210022 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 73.46299744 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 77.96299744 42.92200089 Tm [(IL2)-1(.)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 92.67099762 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 97.17099762 42.92200089 Tm [(Inhibit)1(s)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 128.96099854 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 133.46099854 42.92200089 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 167.94900513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 172.44900513 42.92200089 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 203.70300293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 208.20300293 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 225.42500305 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 229.92500305 42.92200089 Tm [(are)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 243.44299316 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 247.94299316 42.92200089 Tm [(re)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(quired)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 27.99799919 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 32.4980011 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 44.77600098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 49.27600098 58.52199936 Tm [(IL2)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 61.81800079 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 66.31800079 58.52199936 Tm [(pro)1(duc)-1(t)1(ion)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 114.05599976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 118.55599976 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 134.83299255 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 139.33299255 58.52199936 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 170.09500122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 174.59500122 58.52199936 Tm [(pro)1(life)-1(r)1(ation.)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 230.11099243 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 234.61099243 58.52199936 Tm [(Inhib)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(its)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 9.91399956 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 14.41399956 74.12200165 Tm [(ph)1(osph)1(olipase)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 77.38800049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 81.88800049 74.12200165 Tm [(C-g)1(amma-)1(1)-1(/PLCG1)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 165.50700378 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 170.00700378 74.12200165 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 240.78100586 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 245.28100586 74.12200165 Tm [(an)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(d)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(subsequen)-1(t)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 60.29800034 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 64.79799652 89.72200012 Tm [(CD3-induce)-1(d)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 121.46499634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 125.96499634 89.72200012 Tm [(changes)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 161.56900024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 166.06900024 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 174.00999451 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 178.50999451 89.72200012 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 228.977005 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 233.477005 89.72200012 Tm [(free)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 250.24699402 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(calc)-1(ium.)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 34.93700027 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 39.43700027 105.3219986 Tm [(Preven)-1(t)1(s)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 76.38200378 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 80.88200378 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 112.40000153 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 116.90000153 105.3219986 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 172.9960022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 177.4960022 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 186.33799744 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 190.83799744 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 222.35600281 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 226.85600281 105.3219986 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 251.9750061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 8.84200001 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 13.34200001 120.92199707 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 52.49300003 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 56.99300003 120.92199707 Tm [(T-ce)-1(ll)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 80.45500183 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 84.95500183 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 94.02999878 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 98.52999878 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 112.53099823 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 117.03099823 120.92199707 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 152.01600647 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 156.51600647 120.92199707 Tm [(Plays)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 178.32200623 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 182.82200623 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 187.79699707 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 192.29699707 120.92199707 Tm [(role)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 208.95700073 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 213.45700073 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 221.397995 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 225.897995 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 239.89900208 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 244.39900208 120.92199707 Tm [(inh)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ibit)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 27.55400085 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 32.05400085 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 40.89599991 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 45.39599991 136.52200317 Tm [(T-ce)-1(ll)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 68.85800171 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 73.35800171 136.52200317 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 126.70800018 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 131.20799255 136.52200317 Tm [(via)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 143.30200195 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 147.80200195 136.52200317 Tm [(IL1)-1(0)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 165.62199402 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 170.12199402 136.52200317 Tm [(sec)-1(retio)1(n)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 209.46600342 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 213.96600342 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 224.47799683 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 228.97799683 136.52200317 Tm [(cu)-1(t)1(ane)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ous)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 15.43400002 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 19.93400002 152.12199402 Tm [(dendrit)1(i)-1(c)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 58.19300079 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 62.69300079 152.12199402 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 83.43499756 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 87.93499756 152.12199402 Tm [(May)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 106.46700287 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 110.96700287 152.12199402 Tm [(be)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 121.82099915 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 126.32099915 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 131.29600525 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 135.79600525 152.12199402 Tm [(marker)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 166.08299255 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 170.58299255 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 179.42500305 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 183.92500305 152.12199402 Tm [(CD4+)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 208.7539978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 213.2539978 152.12199402 Tm [(CD56)-1(+)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 243.36099243 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 247.86099243 152.12199402 Tm [(le)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(uk)-1(emic)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 30.8939991 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 35.39400101 167.72200012 Tm [(tumor)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 61.88399887 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 66.38400269 167.72200012 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 87.12599945 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.6499939 0.75 m 156.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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