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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(DRO)-1(S)1(HA)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 133.91600037 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 244.35600281 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -66 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -66 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -13.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -3 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 20.625 61.9640007 Tm [(DROS)-1(HA)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 59.80500031 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 112.30499268 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.55499268 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DROSHA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.28900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.66300201 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.31300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.68699646 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.2460022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.61999512 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.41600037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RN)1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.61000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.98400116 12.82499981 Tm [(ET)-1(OHI2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.49900055 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.8730011 12.82499981 Tm [(RN)1(AS)-1(EN)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.96600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.33999634 12.82499981 Tm [(RAN)1(S)-1(E3L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.39199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.76600647 12.82499981 Tm [(RN)1(AS)-1(E3L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.81799316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.19200134 12.82499981 Tm [(HS)-1(A)1(2429)1(76)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.56500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DROS)-1(HA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.55500031 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001100120013000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700130025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 148.7749939 0.75 l 148.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 149.7749939 -0.25 l 149.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 149.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 149.5249939 172.3500061 l h f* Q q 1 0 0 1 149.1499939 0 cm -0.625 -0.25 m 274.2749939 -0.25 l 274.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(ribo)1(n)-1(ucle)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.32499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.82499695 11.72200012 Tm [(\(RNas)1(e)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.77600098 11.72200012 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.71299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.21299744 11.72200012 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.62000084 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.12000084 27.3220005 Tm [(RNA)1(-speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.49500275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.99500275 27.3220005 Tm [(ribo)1(n)-1(ucle)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.6499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.1499939 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.42700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.92700195 27.3220005 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.227005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.727005 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.56900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.06900024 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.07000732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.57000732 27.3220005 Tm [(mic)-1(r)1(opr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(oce)-1(s)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.33200073 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.63899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.13899994 42.92200089 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.78500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.28500366 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.38200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.88200378 42.92200089 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.55400085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.05400085 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.05499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.55499268 42.92200089 Tm [(initial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.00900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.50900269 42.92200089 Tm [(pro)1(c)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(sing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.86400032 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.36400032 58.52199936 Tm [(st)1(e)-1(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.73799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.23799896 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58000183 58.52199936 Tm [(mic)-1(r)1(oRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.60399628 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.10399628 58.52199936 Tm [(\(miRNA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46899414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96899414 58.52199936 Tm [(synthesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.33900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.83900452 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.64599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.14599609 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.65299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.15301514 58.52199936 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 74.12200165 Tm [(cl)-1(eaves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.60800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.10800171 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.10900116 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.60900116 74.12200165 Tm [(st)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.66799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.16799927 74.12200165 Tm [(loop)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.7539978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.2539978 74.12200165 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.71099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.21099854 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.92199707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.42199707 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.42300415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.92300415 74.12200165 Tm [(prima)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11099243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.61099243 74.12200165 Tm [(mi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(croRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.19599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.69599915 89.72200012 Tm [(\(pr)1(i)-1(-)1(miRNA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.53399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.03399658 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.97499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47499847 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.47599792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.97599792 89.72200012 Tm [(nuc)-1(leu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.96099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.46099854 89.72200012 Tm [(yie)-1(lding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.57600403 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.07600403 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.07699585 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.57699585 89.72200012 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.68798828 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(miRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.35300064 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.85300064 105.3219986 Tm [(\(pr)1(e)-1(-)1(m)-1(iR)1(NA\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.56900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.06900024 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.16600037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66600037 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.227005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.727005 105.3219986 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.27400208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.77400208 105.3219986 Tm [(expor)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.56500244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.06500244 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.13999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.63999939 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.64100647 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.14100647 105.3219986 Tm [(cy)-1(t)1(opl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(asm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5739994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.0739994 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.35200119 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.85200119 120.92199707 Tm [(furt)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.39199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.89199829 120.92199707 Tm [(pro)1(c)-1(essing.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.61399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.11399841 120.92199707 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.30499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.80499268 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.77999878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.27999878 120.92199707 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.32099915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.82099915 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.23100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.73100281 120.92199707 Tm [(line)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.17300415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.67300415 120.92199707 Tm [(lack)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.15299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.65301514 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.62799072 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.11000061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.61000061 136.52200317 Tm [(copy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.35700226 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.85700226 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.6989975 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.1989975 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.65499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.15499878 136.52200317 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.83700562 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.33700562 136.52200317 Tm [(canonic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.91600037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.41600037 136.52200317 Tm [(miRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.76899719 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.26899719 136.52200317 Tm [(synthesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.4730072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.97299194 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.53399658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(reduc)-1(ed.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.38899994 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.88899994 152.12199402 Tm [(Somat)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.47399902 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.97399902 152.12199402 Tm [(mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.46199799 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.96200562 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.90299988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.40299988 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.85899353 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.35899353 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.875 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.375 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.72200012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.22200012 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.72900391 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.22900391 152.12199402 Tm [(ob)1(se)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.58699989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.08699989 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.02799988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.52799988 167.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.56900024 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.06900024 167.72200012 Tm [(pa)1(tien)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.71099854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.21099854 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.60700226 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.10699463 167.72200012 Tm [(ki)-1(d)1(ne)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.57499695 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.07499695 167.72200012 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.33099365 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.1499939 0.75 m 149.1499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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6 0 obj
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