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[<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CD86)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.95200348 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.45199585 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 169.70199585 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CD86)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 106.43599701 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 108.80999756 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 134.46000671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 136.83399963 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 180.39300537 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 182.76699829 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 220.56300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD86)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 85.70200348 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 88.0759964 12.82499981 Tm [(mol)-1(e)1(cul)-1(e;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 130.03500366 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 132.40899658 12.82499981 Tm [(B70;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 151.57400513 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 153.94799805 12.82499981 Tm [(B7-2;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 176.32699585 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 178.70100403 12.82499981 Tm [(B7.2;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 200.51600647 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 202.88999939 12.82499981 Tm [(LAB72;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 232.54400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 234.91799927 12.82499981 Tm [(CD28L)-1(G)1(2)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 273.98001099 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD86)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 85.70200348 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 84 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 148.7749939 0.75 l 148.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 149.7749939 -0.25 l 149.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 149.5249939 172.3500061 l h f* Q q 1 0 0 1 149.1499939 0 cm -0.625 -0.25 m 274.2749939 -0.25 l 274.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(type)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 116.64099884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 121.14099884 11.72200012 Tm [(I)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 123.78700256 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 128.28700256 11.72200012 Tm [(membrane)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 175.07099915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 179.57099915 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 210.87800598 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 215.37800598 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 232.6000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 237.1000061 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 243.66099548 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 248.16099548 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 253.13600159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 257.63598633 11.72200012 Tm [(m)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ember)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 27.83099937 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 32.33100128 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 41.17300034 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 45.67300034 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 59.67399979 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 64.1740036 27.3220005 Tm [(immun)-1(o)1(glob)1(u)-1(lin)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 135.7519989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 140.2519989 27.3220005 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 192.50300598 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 197.00300598 27.3220005 Tm [(This)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 214.26499939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 218.76499939 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 250.07200623 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 254.57200623 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 261.13299561 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(expressed)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 43.15399933 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 47.65399933 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 58.16600037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 62.66600037 42.92200089 Tm [(antig)1(e)-1(n-)1(prese)-1(nt)1(i)-1(ng)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 145.39700317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 149.89700317 42.92200089 Tm [(ce)-1(lls,)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 170.63900757 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 175.13900757 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 191.41600037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 195.91600037 42.92200089 Tm [(it)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 201.66400146 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 206.16400146 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 212.7250061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 217.2250061 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 231.22599792 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 235.72599792 42.92200089 Tm [(ligand)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 262.54998779 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 12.27799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 16.77799988 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 32.95899963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 37.45899963 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 72.93199921 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 77.43199921 58.52199936 Tm [(at)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 85.76000214 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 90.26000214 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 104.26100159 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 108.76100159 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 123.17099762 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 127.67099762 58.52199936 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 158.53399658 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 163.03399658 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 171.87600708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 176.37600708 58.52199936 Tm [(T)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 181.53500366 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 186.03500366 58.52199936 Tm [(ce)-1(lls,)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 206.7769928 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 211.2769928 58.52199936 Tm [(CD28)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 234.70899963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 239.20899963 58.52199936 Tm [(antig)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(en)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 10.65200043 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 15.15200043 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 31.42900085 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 35.92900085 74.12200165 Tm [(cy)-1(t)1(oto)1(xic)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 74.82499695 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 79.32499695 74.12200165 Tm [(T-lympho)1(c)-1(yte-a)1(ssoci)-1(a)1(ted)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 187.73800659 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 192.23800659 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 223.54499817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 228.04499817 74.12200165 Tm [(4.)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 235.48899841 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 239.98899841 74.12200165 Tm [(Bi)-1(nd)1(i)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ng)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 11.30300045 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 15.80300045 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 24.64500046 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 29.14500046 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 44.60100174 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 49.10100174 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 80.40799713 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 84.90799713 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 103.30400085 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 107.80400085 89.72200012 Tm [(CD28)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 131.23599243 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 135.73599243 89.72200012 Tm [(antig)1(e)-1(n)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 168.41400146 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 172.91400146 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 179.4750061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 183.9750061 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 188.94999695 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 193.44999695 89.72200012 Tm [(costimulat)1(ory)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 252.22200012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 256.72198486 89.72200012 Tm [(si)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(gnal)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 18.67200089 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 23.17200089 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 35.45000076 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 39.95000076 105.3219986 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 81.90000153 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 86.40000153 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 95.24199677 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 99.74199677 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 113.74299622 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 118.24299622 105.3219986 Tm [(T-ce)-1(ll.)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 143.87199402 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 148.37199402 105.3219986 Tm [(Bi)-1(nd)1(i)-1(ng)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 181.41400146 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 185.91400146 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 194.7559967 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 199.2559967 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 214.71200562 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 219.21200562 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 250.51899719 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 255.01899719 105.3219986 Tm [(wi)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 8.89500046 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 13.39500046 120.92199707 Tm [(cy)-1(t)1(oto)1(xic)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 52.29100037 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 56.79100037 120.92199707 Tm [(T-lympho)1(c)-1(yte-a)1(ssoci)-1(a)1(ted)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 165.20399475 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 169.70399475 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 201.01100159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 205.51100159 120.92199707 Tm [(4)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 210.78900146 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 215.28900146 120.92199707 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 259.41000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 39.8409996 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 44.3409996 136.52200317 Tm [(T-ce)-1(ll)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 67.8030014 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 72.3030014 136.52200317 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 114.25299835 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 118.75299835 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 135.02999878 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 139.52999878 136.52200317 Tm [(diminishes)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 185.43099976 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 189.93099976 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 203.93200684 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 208.43200684 136.52200317 Tm [(immun)-1(e)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 243.89100647 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 248.39100647 136.52200317 Tm [(res)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(po)1(n)-1(se.)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 28.45499992 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 32.95500183 152.12199402 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 79.6780014 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 84.1780014 152.12199402 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 117.09300232 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 121.59300232 152.12199402 Tm [(results)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 149.76199341 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 154.26199341 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 162.20300293 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 166.70300293 152.12199402 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 196.61199951 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 201.11199951 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 242.03399658 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 246.53399658 152.12199402 Tm [(var)1(i)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ants)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 18.04000092 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 22.54000092 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 62.88199997 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 67.38200378 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 104.3219986 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 108.8219986 167.72200012 Tm [(isof)1(orms.)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 148.14900208 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 149.1499939 0.75 m 149.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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