%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 100.93499756 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 150.61099243 23.67700005 Tm 0 Tr [(CD)-1(80)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 203.92399597 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 314.36401367 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CD80)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.95200348 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.45199585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.70199585 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CD80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.43599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.80999756 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.46000671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.83399963 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.39300537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.76699829 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.56300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(B7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.84300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.21700287 12.82499981 Tm [(BB1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.77100372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.14499664 12.82499981 Tm [(B7-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.52400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.89800262 12.82499981 Tm [(B7.1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.71299744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.08700562 12.82499981 Tm [(LAB7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.41999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.79400635 12.82499981 Tm [(CD28L)-1(G)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.34399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.71800232 12.82499981 Tm [(CD28L)-1(G)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.77999878 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.70200348 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 154.7749939 94.34999847 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.42500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.92500305 11.72200012 Tm [(rec)-1(ept)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.87999916 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.38000107 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.94100189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.44100189 27.3220005 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.59200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.09200287 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.60399628 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.10399628 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.10500336 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.60500336 27.3220005 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.74899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.24899292 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.59100342 27.3220005 Tm [(CD28)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.022995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.522995 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.18099976 27.3220005 Tm [(CTLA-4.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.6499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.1499939 27.3220005 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 42.92200089 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.29899979 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.79899979 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.10600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.60600281 42.92200089 Tm [(induc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63500214 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.13499451 42.92200089 Tm [(T-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.59700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.09700012 42.92200089 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.44700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.94700623 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.22399902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.72399902 42.92200089 Tm [(cy)-1(t)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.9470005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.4470005 58.52199936 Tm [(pro)1(duc)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.35099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.85099792 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.11299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.61299896 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.91999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.41999817 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.45399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.95399475 58.52199936 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.79499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.29499817 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.43600464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.93600464 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.91099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.41099548 58.52199936 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.83299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.33299255 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.61099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.11099243 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(denovirus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.39799881 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.89799881 74.12200165 Tm [(subg)1(roup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.56700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06700134 74.12200165 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.71399689 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21399689 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.49099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.99099731 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.16200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.66200256 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.54299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.04299927 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.01800537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.51800537 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.17799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.67799377 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.6190033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.1190033 74.12200165 Tm [(lupus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.52000427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.02000427 74.12200165 Tm [(ne)-1(ur)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(op)1(ath)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.26900101 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CD80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.43199921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CD80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.29499817 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CD80)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.43199921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.93199921 11.72200012 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.14900208 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(B7)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.0909996 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5909996 11.72200012 Tm [(BB)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.32899857 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.82899857 11.72200012 Tm [(B7)-1(-)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.09199905 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.59200287 11.72200012 Tm [(B7)-1(.1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.12799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.62799835 11.72200012 Tm [(LAB7)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.66999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.16999817 11.72200012 Tm [(CD28)-1(LG)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.08000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.58000183 11.72200012 Tm [(CD28)-1(LG)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.60099792 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 0.75 m 154.3999939 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 95.09999847 m 154.3999939 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 111.44999695 m 154.3999939 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 127.79999542 m 154.3999939 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 144.1499939 m 154.3999939 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 160.5 m 154.3999939 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 176.4750061 m 423.17498779 176.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>