%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 100.93499756 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 150.61099243 23.67700005 Tm 0 Tr [(CD)-1(70)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 203.92399597 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 314.36401367 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CD70)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.95200348 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.45199585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.95199585 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CD70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.43599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.80999756 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.46000671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.83399963 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.39300537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.76699829 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.56300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD70;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.51200104 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.47899628 12.82499981 Tm [(CD27L)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.40499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.37199402 12.82499981 Tm [(CD27L)-1(G)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.92199707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.88900757 12.82499981 Tm [(TNFS)-1(F7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.38800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.35499573 12.82499981 Tm [(CD70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.05700684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.02400208 12.82499981 Tm [(anti)-1(ge)1(n;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.98999023 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.95700073 12.82499981 Tm [(Tu)-1(mor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.17599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.14300537 12.82499981 Tm [(necr)1(o)-1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.14498901 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 358.11199951 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.50100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.46798706 12.82499981 Tm [(li)-1(gand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29199219 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(su)-1(pe)1(rfami)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.21900177 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5929985 30.49699783 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.9940033 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.36799622 30.49699783 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.69000244 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD70)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.70200348 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 152.5249939 0.75 l 152.5249939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 153.5249939 -0.25 l 153.5249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 153.2749939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 153.2749939 141.1499939 l h f* Q q 1 0 0 1 152.8999939 0 cm -0.625 -0.25 m 270.5249939 -0.25 l 270.5249939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.44000244 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.66200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.16200256 11.72200012 Tm [(belo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ngs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.46899986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.96899986 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.04400063 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.54399872 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.54499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.04499817 27.3220005 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.53500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.03500366 27.3220005 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.08599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.58599854 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.70500183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.20500183 27.3220005 Tm [(\(TNF\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.47399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.97399902 27.3220005 Tm [(ligand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.79800415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.29800415 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.54600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.04600525 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.30801392 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29899979 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.79899979 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.36000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.86000061 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.83499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.33499908 42.92200089 Tm [(ligand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.15899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.65899658 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.93699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.43699646 42.92200089 Tm [(TNFRSF)-1(27)-1(/CD)1(2)-1(7.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.54400635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.04400635 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.04299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.54299927 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.10400391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.60400391 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.57899475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.07899475 42.92200089 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.94200134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.44200134 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ntigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.70299911 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.20299911 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.47100067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.97100067 58.52199936 Tm [(activat)1(ed,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.28800201 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.78800201 58.52199936 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.43499756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.93499756 58.52199936 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.55599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.05599976 58.52199936 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.32400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.82400513 58.52199936 Tm [(resting,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.75 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.25 58.52199936 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.40899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.90899658 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.18600464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.68600464 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.33299255 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.83299255 58.52199936 Tm [(lymphoc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ytes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.55599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.05599976 74.12200165 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.05500031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.55500031 74.12200165 Tm [(induc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.58399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.08399963 74.12200165 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.43399811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.93400574 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.77600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.27600098 74.12200165 Tm [(costimulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.99000549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.49000549 74.12200165 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.64900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.14900208 74.12200165 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.89100647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.39100647 74.12200165 Tm [(en)-1(h)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.33200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.83200073 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.83300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.33300018 89.72200012 Tm [(gene)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.27500153 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.77500153 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.61699677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.11699677 89.72200012 Tm [(cy)-1(t)1(olytic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.88800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.38800049 89.72200012 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.54699707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.04699707 89.72200012 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.78900146 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.28900146 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.56599426 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.06599426 89.72200012 Tm [(contribut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.95100403 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.45098877 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 105.3219986 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.38099957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.88100052 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.29100037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.79100037 105.3219986 Tm [(activat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.90799713 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.40799713 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16999817 105.3219986 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.46899414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.96899414 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.52999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.02999878 105.3219986 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.28700256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.78700256 105.3219986 Tm [(repor)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.45300293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.95300293 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.02799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.52799988 105.3219986 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.40899658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 120.92199707 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.13500023 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.63500023 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.57600021 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.07600021 120.92199707 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.34200287 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.84200287 120.92199707 Tm [(B-c)-1(ell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.79199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.29199982 120.92199707 Tm [(activat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.40899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.90899658 120.92199707 Tm [(cy)-1(t)1(oto)1(xic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.80499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.30499268 120.92199707 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.04600525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.54600525 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.38800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(natura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.22599983 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.72600174 136.52200317 Tm [(ki)-1(ller)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.35400009 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.85400009 136.52200317 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.59600067 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.09600067 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.3730011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.8730011 136.52200317 Tm [(immun)-1(o)1(glob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.45100403 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.95100403 136.52200317 Tm [(syth)1(e)-1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.7749939 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 152.5249939 0.75 l 152.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 153.5249939 -0.25 l 153.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 153.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 153.2749939 16.35000038 l h f* Q q 1 0 0 1 152.8999939 0 cm -0.625 -0.25 m 270.5249939 -0.25 l 270.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.8999939 0.75 m 152.8999939 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.8999939 141.8999939 m 152.8999939 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.875 m 423.17498779 157.875 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>