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BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT 1 0 0 -1 -35.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -11.875 61.9640007 Tm [(DRG1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 14.85700226 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 67.35699463 61.9640007 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 72.60699463 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DRG1)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 107.83999634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 110.21399689 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 135.86399841 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 138.23800659 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 181.79699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 184.17100525 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 221.96699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NEDD3)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 93.14600372 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DRG1)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 87.10700226 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 71 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 162.2749939 0.75 l 162.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 163.2749939 -0.25 l 163.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 163.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 163.0249939 172.3500061 l h f* Q q 1 0 0 1 162.6499939 0 cm -0.625 -0.25 m 260.7749939 -0.25 l 260.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 77 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(DRG)1(1)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 24.70199966 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 29.20199966 11.72200012 Tm [(\(developmentally)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 103.73300171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 108.23300171 11.72200012 Tm [(regulat)1(e)-1(d)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 149.66499329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 154.16499329 11.72200012 Tm [(GTP)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 171.522995 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 176.022995 11.72200012 Tm [(binding)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 209.16700745 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 213.66700745 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 244.97399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(1\),)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 10.44999981 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 14.94999981 27.3220005 Tm [(also)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 32.20700073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 36.70700073 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 65.52600098 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 70.02600098 27.3220005 Tm [(as)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 79.16699982 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 83.66699982 27.3220005 Tm [(NEDD)1(3)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 114.92099762 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 119.42099762 27.3220005 Tm [(\(ne)-1(ura)1(l)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 149.43099976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 153.93099976 27.3220005 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 195.04200745 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 199.54200745 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 213.95199585 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 218.45199585 27.3220005 Tm [(express)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ed)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 10.86299992 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 15.36299992 42.92200089 Tm [(developmentally)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 86.88800049 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 91.38800049 42.92200089 Tm [(do)1(wn-regulat)1(e)-1(d)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 160.84399414 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 165.34399414 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 196.65100098 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 201.15100098 42.92200089 Tm [(3\),)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 211.60099792 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 216.10099792 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 222.66200256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 227.16200256 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 232.13699341 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 236.63699341 42.92200089 Tm [(36)-1(7)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 252.47000122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(amino)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 27.06999969 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 31.56999969 58.52199936 Tm [(acid)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 49.20999908 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 53.70999908 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 85.01699829 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 89.51699829 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 106.73899841 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 111.23899841 58.52199936 Tm [(localizes)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 147.33099365 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 151.83099365 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 160.90600586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 165.40600586 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 179.40699768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 183.90699768 58.52199936 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 227.9750061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 232.4750061 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 248.7519989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(belongs)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 34.43999863 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 38.93999863 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 48.01499939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 52.51499939 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 66.51599884 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 71.01599884 74.12200165 Tm [(GTP1/OB)-1(G)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 117.17199707 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 121.67199707 74.12200165 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 149.91999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 154.41999817 74.12200165 Tm [(Exp)1(re)-1(s)1(se)-1(d)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 197.41600037 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 201.91600037 74.12200165 Tm [(at)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 210.2440033 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 214.7440033 74.12200165 Tm [(hig)1(h)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 233.97900391 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 238.47900391 74.12200165 Tm [(lev)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(els)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 11.66699982 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 16.16699982 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 24.1079998 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 28.6079998 89.72200012 Tm [(heart)1(,)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 53.18700027 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 57.68700027 89.72200012 Tm [(ki)-1(d)1(ne)-1(y)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 86.15499878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 90.65499878 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 106.93199921 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 111.43199921 89.72200012 Tm [(ske)-1(leta)1(l)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 143.82800293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 148.32800293 89.72200012 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 178.48800659 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 182.98800659 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 199.26499939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 203.76499939 89.72200012 Tm [(at)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 212.09300232 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 216.59300232 89.72200012 Tm [(low)1(e)-1(r)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 240.35899353 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 244.85899353 89.72200012 Tm [(le)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(vels)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 16.3920002 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 20.8920002 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 28.83300018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 33.33300018 105.3219986 Tm [(bra)1(in)-1(,)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 57.59999847 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 62.09999847 105.3219986 Tm [(live)-1(r)1(,)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 82.3239975 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 86.8239975 105.3219986 Tm [(placen)-1(t)1(a,)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 125.60099792 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 130.10099792 105.3219986 Tm [(lun)-1(g)1(,)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 151.51100159 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 156.01100159 105.3219986 Tm [(colon)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 179.90800476 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 184.40800476 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 200.68499756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 205.18499756 105.3219986 Tm [(spleen)-1(,)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 235.41900635 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 239.91900635 105.3219986 Tm [(D)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(RG)1(1)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 17.84600067 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 22.34600067 120.92199707 Tm [(binds)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 45.95800018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 50.45800018 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 59.53300095 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 64.03299713 120.92199707 Tm [(TAL1)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 85.42099762 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 89.92099762 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 106.19799805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 110.69799805 120.92199707 Tm [(TAL2)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 132.08599854 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 136.58599854 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 152.86300659 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 157.36300659 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 163.92399597 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 168.42399597 120.92199707 Tm [(th)1(ought)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 203.23699951 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 207.73699951 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 216.81199646 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 221.31199646 120.92199707 Tm [(play)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 239.19299316 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 243.69299316 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 248.66799927 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(role)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 16.65999985 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 21.15999985 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 29.10099983 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 33.60100174 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 48.01100159 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 52.51100159 136.52200317 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 105.86100006 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 110.36100006 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 126.63800049 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 131.13800049 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion,)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 194.63000488 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 199.13000488 136.52200317 Tm [(as)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 208.27099609 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 212.77099609 136.52200317 Tm [(well)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 229.772995 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 234.272995 136.52200317 Tm [(as)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 243.41400146 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 247.91400146 136.52200317 Tm [(i)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 54.20700073 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 58.70700073 152.12199402 Tm [(sugg)1(e)-1(st)1(in)-1(g)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 106.2559967 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 110.7559967 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 115.73100281 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 120.23100281 152.12199402 Tm [(role)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 136.89100647 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 141.39100647 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 149.33200073 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 153.83200073 152.12199402 Tm [(tumor)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 180.32200623 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 184.82200623 152.12199402 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 227.52400208 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 232.02400208 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 248.30099487 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(metast)1(asis.)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 47.25400162 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 51.75400162 167.72200012 Tm [(DRG)1(1)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 76.45600128 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 80.95600128 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 87.51699829 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 92.01699829 167.72200012 Tm [(subjec)-1(t)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 122.85299683 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 127.35299683 167.72200012 Tm [(to)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 136.42799377 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 140.92799377 167.72200012 Tm [(po)1(l)-1(yubiq)1(u)-1(it)1(in)-1(a)1(tion)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 220.227005 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 224.727005 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 241.0039978 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 245.5039978 167.72200012 Tm [(s)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 162.6499939 0.75 m 162.6499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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