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0 -1 -66 43.75799942 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -66 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT 1 0 0 -1 -13.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.125 61.9640007 Tm [(DR1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 30.23300171 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 82.73300171 61.9640007 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 87.98300171 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DR1)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 101.21600342 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 103.58999634 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 129.24000549 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 131.61399841 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 175.17300415 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 177.54699707 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 215.34300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(do)-1(wn-re)1(gul)-1(ator)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 129.78900146 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 132.16299438 12.82499981 Tm [(of)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 140.90400696 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 143.27799988 12.82499981 Tm [(transcripti)-1(on)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 198.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 200.49000549 12.82499981 Tm [(1)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 205.81199646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 208.18600464 12.82499981 Tm [(NC2;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 228.69400024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 231.06799316 12.82499981 Tm [(NC2B)1(;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 257.2869873 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 259.66101074 12.82499981 Tm [(NC2-BETA)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 302.60400391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DR1)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 80.48300171 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 90.98300171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 90 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 91 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 92 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 93 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 160.0249939 0.75 l 160.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 161.0249939 -0.25 l 161.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 160.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 160.7749939 172.3500061 l h f* Q q 1 0 0 1 160.3999939 0 cm -0.625 -0.25 m 263.0249939 -0.25 l 263.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(TB)-1(P)1(-)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 117.87599945 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 122.37599945 11.72200012 Tm [(\(TATA)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 148.36500549 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 152.86500549 11.72200012 Tm [(bo)1(x-binding)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 205.93299866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 210.43299866 11.72200012 Tm [(pro)1(tein)-1(\))] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 244.74499512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 249.24499512 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ssociat)1(e)-1(d)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 40.15299988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 44.65299988 27.3220005 Tm [(ph)1(osph)1(opro)1(tein)] TJ ET EMC /P 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42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 43.65100098 42.92200089 Tm [(leve)-1(ls)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 67.54399872 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 72.04399872 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 80.88600159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 85.38600159 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tion.)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 142.13699341 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 146.63699341 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 162.44400024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 166.94400024 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 204.45100403 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 208.95100403 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 240.25799561 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 244.75799561 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 251.31900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ph)1(osph)1(orylated)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 67.97499847 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 72.47499847 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 80.41600037 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 84.91600037 58.52199936 Tm [(vivo)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 102.48100281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 106.98100281 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 123.25800323 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 127.75800323 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 143.21400452 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 147.71400452 58.52199936 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 218.48800659 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 222.98800659 58.52199936 Tm [(af)1(fec)-1(t)1(s)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 251.34199524 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(its)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 9.91399956 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 14.41399956 74.12200165 Tm [(interaction)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 60.75400162 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 65.2539978 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 83.65000153 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 88.15000153 74.12200165 Tm [(TB)-1(P)1(.)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 106.6289978 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 111.1289978 74.12200165 Tm [(This)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 128.39100647 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 132.89100647 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 164.19799805 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 168.69799805 74.12200165 Tm [(contains)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 204.91299438 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 209.41299438 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 214.38800049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 218.88800049 74.12200165 Tm [(hist)1(one)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 250.71800232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(fo)1(l)-1(d)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 16.99399948 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 21.49399948 89.72200012 Tm [(mot)1(if)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 44.51699829 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 49.01699829 89.72200012 Tm [(at)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 57.34500122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 61.84500122 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 75.84600067 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 80.34600067 89.72200012 Tm [(amino)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 107.41600037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 111.91600037 89.72200012 Tm [(terminus,)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 152.06399536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 156.56399536 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 161.53900146 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 166.03900146 89.72200012 Tm [(TB)-1(P)1(-binding)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 219.38900757 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 223.88900757 89.72200012 Tm [(do)1(mai)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(n,)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 7.71199989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 12.21199989 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 28.48900032 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 32.98899841 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 37.9640007 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 42.4640007 105.3219986 Tm [(gluta)1(min)-1(e-)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 89.86299896 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 94.36299896 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 110.63999939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 115.13999939 105.3219986 Tm [(alanine)-1(-)1(ric)-1(h)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 165.85699463 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 170.35699463 105.3219986 Tm [(region.)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 200.48599243 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 204.98599243 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 220.79299927 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 225.29299927 105.3219986 Tm [(bindin)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(g)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 19.09900093 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 23.59900093 120.92199707 Tm [(DR1)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 41.60800171 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 46.10800171 120.92199707 Tm [(repressor)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 86.43199921 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 90.93199921 120.92199707 Tm [(complexe)-1(s)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 136.68299866 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 141.18299866 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 150.25799561 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 154.75799561 120.92199707 Tm [(TB)-1(P)1(-pro)1(moter)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 215.92100525 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 220.42100525 120.92199707 Tm [(comple)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(xes)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 13.83399963 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 18.33399963 136.52200317 Tm [(may)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 36.50500107 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 41.00500107 136.52200317 Tm [(estab)1(lish)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 78.85099792 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 83.35099792 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 88.3259964 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 92.8259964 136.52200317 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 141.93499756 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 146.43499756 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 154.37600708 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 158.87600708 136.52200317 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 183.9730072 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 188.4730072 136.52200317 Tm [(an)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 198.9940033 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 203.4940033 136.52200317 Tm [(alt)1(e)-1(red)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 233.6230011 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 238.1230011 136.52200317 Tm [(DN)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(A)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 6.33300018 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 10.83300018 152.12199402 Tm [(conforma)1(tion,)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 71.48200226 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 75.98200226 152.12199402 Tm [(to)1(gether)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 113.35700226 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 117.85700226 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 136.25300598 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 140.75300598 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 154.7539978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 159.2539978 152.12199402 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 201.95599365 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 206.45599365 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 215.29800415 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 219.79800415 152.12199402 Tm [(hig)1(he)-1(r)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 247.57600403 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ord)1(e)-1(r)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 23.45800018 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 27.95800018 167.72200012 Tm [(complexe)-1(s)1(,)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 75.87599945 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 80.37599945 167.72200012 Tm [(inhibits)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 111.91600037 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 116.41600037 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 130.41700745 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 134.91700745 167.72200012 Tm [(assembly)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 174.66999817 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 179.16999817 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 188.01199341 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 192.51199341 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 206.51300049 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 211.01300049 167.72200012 Tm [(preinitiat)1(i)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.3999939 0.75 m 160.3999939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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