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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 6.17799997 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 55.85400009 23.67700005 Tm 0 Tr [(DP)-1(Y)1(SL2)1(\(Pho)1(spho)1(-Thr)-1(5)1(14\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.68099976 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 298.68099976 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 409.1210022 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(DPYS)-1(L2\(Phos)-1(pho)-1(-Th)-1(r)1(514\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.68299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 189.93299866 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 242.43299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.68299866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(DP)1(Y)-1(SL)-1(2)1(\()-1(P)1(h)-1(osp)-1(ho-T)-1(hr51)1(4\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.29200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.66600037 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.31599426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.69000244 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.24899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.62298584 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.41900635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DRP2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.71700287 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.09100342 12.82499981 Tm [(N2)1(A3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.39700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.77100372 12.82499981 Tm [(CRMP2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.60400391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.97799683 12.82499981 Tm [(DRP-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.28300476 12.82499981 Tm [(ULIP2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.00900269 12.82499981 Tm [(CRMP-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.05599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42999268 12.82499981 Tm [(DHPRP)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.11300659 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.48699951 12.82499981 Tm [(ULIP-2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.24398804 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DPYS)-1(L2\(Phos)-1(pho)-1(-Th)-1(r)1(514\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.55799866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 145.7749939 0.75 l 145.7749939 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 146.7749939 -0.25 l 146.7749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.5249939 0.75 m 422.375 0.75 l 422.375 109.94999695 l 146.5249939 109.94999695 l h f* Q q 1 0 0 1 146.1499939 0 cm -0.625 -0.25 m 277.2250061 -0.25 l 277.2250061 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(collapsin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.1309967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.6309967 11.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.62800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.12799072 11.72200012 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ediat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.74399948 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.24399948 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.5510025 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.0510025 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.2990036 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.7990036 27.3220005 Tm [(Collap)1(sin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.16099548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.66099548 27.3220005 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.65800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.15800476 27.3220005 Tm [(mediat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.33500671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.83500671 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.37700081 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.8769989 42.92200089 Tm [(ho)1(mo-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.18899918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.68900299 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.46600342 42.92200089 Tm [(hetero-)1(tetra)1(me)-1(rs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.99099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.49099731 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.76800537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.26800537 42.92200089 Tm [(fa)1(c)-1(ilitat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.8480072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.3480072 42.92200089 Tm [(ne)-1(uro)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.25 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(guida)1(n)-1(ce,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.76100159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.26100159 58.52199936 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.17700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.67700195 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.95400238 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.45400238 58.52199936 Tm [(po)1(l)-1(a)1(rity.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.40800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.90800476 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.71499634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.21499634 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.72200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.22200012 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.52900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.02900696 58.52199936 Tm [(pro)1(mo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.625 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.125 74.12200165 Tm [(mic)-1(r)1(otubule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.31900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.81900024 74.12200165 Tm [(assembly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.5719986 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.0719986 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.34899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.84899902 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.41000366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.91000366 74.12200165 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45100403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.95100403 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.22900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.72900391 74.12200165 Tm [(Se)-1(ma)1(3)-1(A)1(-medi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(at)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.19099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.69099998 89.72200012 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.60699844 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.10699844 89.72200012 Tm [(cone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.9940033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.4940033 89.72200012 Tm [(collapse,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.68099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.18099976 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.45799255 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.95799255 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.21499634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.71499634 89.72200012 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.76199341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.26199341 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.23699951 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.73699951 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.39700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.89700317 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.83799744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33799744 89.72200012 Tm [(synapt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.90799999 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.40799999 105.3219986 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.3390007 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.8390007 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.73600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.23600006 105.3219986 Tm [(interactions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.74200439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24200439 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.63800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.13800049 105.3219986 Tm [(calc)-1(ium)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.90800476 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.40800476 105.3219986 Tm [(channe)-1(ls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.36300659 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.7749939 0.75 l 145.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.7749939 -0.25 l 146.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 146.5249939 16.35000038 l h f* Q q 1 0 0 1 146.1499939 0 cm -0.625 -0.25 m 277.2250061 -0.25 l 277.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 145.7749939 0.75 l 145.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.7749939 -0.25 l 146.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 146.5249939 16.35000038 l h f* Q q 1 0 0 1 146.1499939 0 cm -0.625 -0.25 m 277.2250061 -0.25 l 277.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(DPY)1(SL2)-1(\(Ph)1(osph)1(o-Thr514)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.70700073 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 145.7749939 0.75 l 145.7749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 146.7749939 -0.25 l 146.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.5249939 0.75 m 422.375 0.75 l 422.375 31.95000076 l 146.5249939 31.95000076 l h f* Q q 1 0 0 1 146.1499939 0 cm -0.625 -0.25 m 277.2250061 -0.25 l 277.2250061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(Threonin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(51)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.43899918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.93899918 27.3220005 Tm [(\(K-)1(V)-1(-)1(T\(p\)-P-)1(A\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.08200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.58200073 27.3220005 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.86399841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.36399841 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.07499695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.57499695 27.3220005 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.03500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.53500366 27.3220005 Tm [(DRP)1(-2.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.11000061 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.1499939 0.75 m 146.1499939 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.1499939 110.69999695 m 146.1499939 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.1499939 127.04999542 m 146.1499939 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.1499939 143.3999939 m 146.1499939 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.375 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.375 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.375 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97499084 m 423.125 174.97499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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