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[<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(BFAR)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.56199646 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.06199646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 169.31199646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BFAR)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 106.04599762 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 108.41999817 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 134.07000732 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 136.44400024 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 180.00300598 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 182.3769989 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 220.17300415 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BAR;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 83.29799652 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 85.67199707 12.82499981 Tm [(RN)1(F)-1(47)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 113.6190033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BFAR)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 85.31199646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 74 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 77 >> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 152.17500305 0.75 l 152.17500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 153.17500305 -0.25 l 153.17500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.92500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 152.92500305 172.3500061 l h f* Q q 1 0 0 1 152.55000305 0 cm -0.625 -0.25 m 270.875 -0.25 l 270.875 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(A)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 6.33300018 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 10.83300018 11.72200012 Tm [(novel)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 34.32600021 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 38.82600021 11.72200012 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 72.2990036 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 76.7990036 11.72200012 Tm [(BAR,)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 96.81999969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 101.31999969 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 113.59799957 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 118.09799957 11.72200012 Tm [(bif)1(u)-1(nctional)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 169.35099792 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 173.85099792 11.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 215.84500122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 220.34500122 11.72200012 Tm [(regulat)1(or,)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 262.23800659 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(contains)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 36.21500015 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 40.71500015 27.3220005 Tm [(do)1(mains)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 77.70800018 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 82.20800018 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 99.43000031 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 103.93000031 27.3220005 Tm [(en)-1(a)1(ble)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 132.80599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 137.30599976 27.3220005 Tm [(it)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 143.05400085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 147.55400085 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 156.6289978 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 161.1289978 27.3220005 Tm [(interact)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 193.80700684 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 198.30700684 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 216.70300293 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 221.20300293 27.3220005 Tm [(compone)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nts)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 13.06499958 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 17.56500053 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 26.40699959 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 30.90699959 42.92200089 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 51.27099991 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 55.77099991 42.92200089 Tm [(major)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 80.74099731 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 85.24099731 42.92200089 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 127.23500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 131.73500061 42.92200089 Tm [(pa)1(thw)1(ays,)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 174.52900696 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 179.02900696 42.92200089 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 205.32600403 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 209.82600403 42.92200089 Tm [(it)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 215.57400513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 220.07400513 42.92200089 Tm [(ne)-1(g)1(ativel)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(y)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 4.76399994 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 9.26399994 58.52199936 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 49.10499954 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 53.60499954 58.52199936 Tm [(ap)1(opt)1(otic)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 95.13300323 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 99.63300323 58.52199936 Tm [(signaling.)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 140.73100281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 145.23100281 58.52199936 Tm [(Lik)-1(e)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 162.25100708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 166.75100708 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 180.7519989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 185.2519989 58.52199936 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 208.41099548 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 212.91099548 58.52199936 Tm [(anti-)1(apo)1(pt)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(osis)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 16.4489994 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 20.9489994 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 56.42200089 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 60.92200089 74.12200165 Tm [(Bap31)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 87.84700012 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 92.34700012 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 108.62400055 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 113.12400055 74.12200165 Tm [(FLIP,)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 132.84199524 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 137.34199524 74.12200165 Tm [(BAR)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 155.19700623 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 159.69700623 74.12200165 Tm [(contains)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 195.91200256 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 200.41200256 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 205.38699341 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 209.88699341 74.12200165 Tm [(DED)1(-lik)-1(e)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 247.23599243 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 251.73599243 74.12200165 Tm [(d)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(oma)1(i)-1(n)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 27.06999969 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 31.56999969 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 48.79199982 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 53.29199982 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 59.85300064 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 64.35299683 89.72200012 Tm [(capab)1(le)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 97.81300354 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 102.31300354 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 111.15499878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 115.65499878 89.72200012 Tm [(supp)1(re)-1(ss)1(i)-1(ng)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 167.43600464 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 171.93600464 89.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 213.92999268 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 218.42999268 89.72200012 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 259.31201172 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(at)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 8.32800007 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 12.82800007 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 26.82900047 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 31.32900047 105.3219986 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 67.75099945 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 72.25099945 105.3219986 Tm [(leve)-1(l.)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 94.14499664 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 98.64499664 105.3219986 Tm [(In)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 106.83599854 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 111.33599854 105.3219986 Tm [(ad)1(dition,)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 149.40100098 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 153.90100098 105.3219986 Tm [(BAR)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 171.7559967 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 176.2559967 105.3219986 Tm [(contains)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 212.47099304 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 216.97099304 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 221.94599915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 226.44599915 105.3219986 Tm [(do)1(main)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 259.27301025 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 17.22200012 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 21.72200012 120.92199707 Tm [(also)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 38.97900009 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 43.47900009 120.92199707 Tm [(en)-1(a)1(bles)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 76.52100372 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 81.02100372 120.92199707 Tm [(it)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 86.76899719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 91.26899719 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 100.34400177 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 104.84400177 120.92199707 Tm [(interact)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 137.52200317 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 142.02200317 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 160.41799927 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 164.91799927 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 178.91900635 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 183.41900635 120.92199707 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 243.602005 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 248.102005 120.92199707 Tm [(Bc)-1(l)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(-2)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 9.17099953 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 13.67099953 136.52200317 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 39.75299835 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 44.25299835 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 53.09500122 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 57.59500122 136.52200317 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 95.23400116 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 99.73400116 136.52200317 Tm [(The)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 115.54100037 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 120.04100037 136.52200317 Tm [(presenc)-1(e)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 158.77000427 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 163.27000427 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 172.11199951 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 176.61199951 136.52200317 Tm [(th)1(e)-1(se)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 199.88499451 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 204.38499451 136.52200317 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 235.34899902 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 239.84899902 136.52200317 Tm [(RING)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(,)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 2.16700006 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 6.66699982 152.12199402 Tm [(SAM,)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 29.15399933 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 33.65399933 152.12199402 Tm [(DED)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 52.31299973 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 56.81299973 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 73.08999634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 77.58999634 152.12199402 Tm [(TM)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 91.54299927 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 96.04299927 152.12199402 Tm [(do)1(mains)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 133.03599548 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 137.53599548 152.12199402 Tm [(sugg)1(e)-1(st)1(s)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 175.55299377 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 180.05299377 152.12199402 Tm [(th)1(at)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 197.2749939 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 201.7749939 152.12199402 Tm [(BAR)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 219.63000488 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 224.13000488 152.12199402 Tm [(may)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 242.30099487 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 246.80099487 152.12199402 Tm [(ser)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ve)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 9.83100033 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 14.33100033 167.72200012 Tm [(as)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 23.47200012 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 27.97200012 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 32.9469986 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 37.4469986 167.72200012 Tm [(scaff)1(old)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 71.21499634 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 75.71499634 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 107.02200317 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 111.52200317 167.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 128.7440033 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 133.2440033 167.72200012 Tm [(integra)1(tes)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 176.43800354 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 180.93800354 167.72200012 Tm [(signaling)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 219.8690033 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 224.3690033 167.72200012 Tm [(compon)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.55000305 0.75 m 152.55000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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