%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 157 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 97.08899689 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 146.76499939 23.67700005 Tm 0 Tr [(BE)1(ST1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 207.77000427 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 318.20999146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(BES)-1(T1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 115.35099792 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.85099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.60099792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BEST)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.83499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.20899963 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.85899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23300171 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.79200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.16600037 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.96200562 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ARB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.10800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.48200226 12.82499981 Tm [(BMD,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.25099945 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.625 12.82499981 Tm [(BES)-1(T,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.02400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.397995 12.82499981 Tm [(RP5)1(0,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.78700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.16099548 12.82499981 Tm [(VMD)-1(2)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.49699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.8710022 12.82499981 Tm [(TU15B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.07899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BES)-1(T1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.10099792 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 173.92500305 0.75 l 173.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 174.92500305 -0.25 l 174.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 174.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 174.67500305 172.3500061 l h f* Q q 1 0 0 1 174.30000305 0 cm -0.625 -0.25 m 249.125 -0.25 l 249.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(bestr)1(oph)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.03900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.53900146 11.72200012 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.85400009 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.35400009 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.61600113 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.11599731 27.3220005 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.48000336 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.98000336 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.4960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.9960022 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.07800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.57800293 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.63900757 27.3220005 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.17199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.67199707 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.18400574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.47299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.97299957 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.36899948 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.86899948 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.84400177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.34400177 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.73799896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.23799896 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.31500244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.81500244 42.92200089 Tm [(N-t)1(e)-1(r)1(mi)-1(nus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.00700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.50700378 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.90299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.40299988 42.92200089 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ur)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.98200035 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.48200035 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.55699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.05699921 58.52199936 Tm [(six)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.18000031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.68000031 58.52199936 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.94000244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.44000244 58.52199936 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.6000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.1000061 58.52199936 Tm [(Be)-1(st)1(roph)1(in)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.92700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.42700195 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.5980072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.0980072 58.52199936 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5909996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.0909996 74.12200165 Tm [(chloride)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.95700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.45700073 74.12200165 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.12000275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.62000275 74.12200165 Tm [(channe)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.40899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.90899658 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.06700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.56700134 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.73800659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.23800659 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.91299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.41299438 74.12200165 Tm [(volt)1(age-g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(at)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.19099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.69099998 89.72200012 Tm [(L-t)1(y)-1(p)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.17399979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.67399979 89.72200012 Tm [(calc)-1(ium-ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.5 89.72200012 Tm [(channe)-1(ls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.45500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.95500183 89.72200012 Tm [(Be)-1(st)1(roph)1(in)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.78199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.28199768 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.80000305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.30000305 89.72200012 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ne)-1(r)1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.61700058 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.11700058 105.3219986 Tm [(belie)-1(ved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.45500183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.95500183 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02999878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52999878 105.3219986 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.24099731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.74099731 105.3219986 Tm [(calc)-1(ium-a)1(c)-1(t)1(i)-1(va)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.55499268 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.05499268 105.3219986 Tm [(chloride-io)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 120.92199707 Tm [(channe)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.83499908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.33499908 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.27600098 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.77600098 120.92199707 Tm [(epith)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.18599701 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.68599701 120.92199707 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.26200104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.76199341 120.92199707 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.40899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.90899658 120.92199707 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.67399597 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.17399597 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.52099609 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.02099609 120.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.27799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.77799988 120.92199707 Tm [(bee)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 136.52200317 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.1269989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.6269989 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.70199966 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.20199966 136.52200317 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.55599976 136.52200317 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.94999695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.44999695 136.52200317 Tm [(permeable)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.50500488 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.00500488 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.08000183 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.58000183 136.52200317 Tm [(bicarb)1(onate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.09700012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.59700012 136.52200317 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.25999451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.73500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.23500061 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.17599869 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.67599869 152.12199402 Tm [(retinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.88300323 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.38300323 152.12199402 Tm [(tiss)1(u)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.28199768 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.78199768 152.12199402 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.6309967 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.1309967 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.07200623 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.57200623 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.02799988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.52799988 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.04400635 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.54400635 152.12199402 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.06199646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.53499985 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.03499985 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.31300354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.81300354 167.72200012 Tm [(juve)-1(nile-onset)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.82200623 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.32200623 167.72200012 Tm [(vitelliform)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.79699707 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.29699707 167.72200012 Tm [(macul)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.57000732 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.07000732 167.72200012 Tm [(dys)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.30000305 0.75 m 174.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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