%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 133 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.3710022 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.04699707 23.67700005 Tm 0 Tr [(CXCR4)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.48899841 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.9289856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.18499756 12.82499981 Tm [(CXCR4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 114.48000336 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 166.97999573 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.22999573 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CXCR4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.40399933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.77799988 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.80200195 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.36099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.73500061 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.53100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FB22;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.98899841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77100372 12.82499981 Tm [(HM89;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.74299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.52500153 12.82499981 Tm [(LAP3)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.57000732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.352005 12.82499981 Tm [(LC)-1(R1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.19700623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.97900391 12.82499981 Tm [(NP)1(YR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.80900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.59100342 12.82499981 Tm [(WHIM;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.90699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.68899536 12.82499981 Tm [(CD184;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.52200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.3039856 12.82499981 Tm [(LAP-3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.56399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.3460083 12.82499981 Tm [(LE)-1(STR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.33898926 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.1210022 12.82499981 Tm [(NP)1(Y3R;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.27200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.0539856 12.82499981 Tm [(NP)1(YRL)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(WHIMS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.13999939 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.51399994 30.49699783 Tm [(HS)-1(Y3RR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.53099823 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.90499878 30.49699783 Tm [(NP)1(YY)-1(3R;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.17299652 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.54699707 30.49699783 Tm [(D2S)-1(2)1(01E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.24499512 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CXCR4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019001A001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D001E001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00200004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001F0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q /GS2 gs 1 g -1.45000005 431.32901001 m 416.75 431.32901001 l 416.75 449.32901001 l -1.45000005 449.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 45.40299988 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 449.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 155.5249939 141.1499939 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(CXC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.51599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.01599884 11.72200012 Tm [(che)-1(mo)1(k)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27900696 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.77900696 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.20100403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.70100403 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.65800476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.15800476 11.72200012 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 27.3220005 Tm [(st)1(romal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.41699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.91699982 27.3220005 Tm [(ce)-1(ll-d)1(e)-1(rived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.5019989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.0019989 27.3220005 Tm [(fa)1(c)-1(t)1(or-1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.45899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.95899963 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.76600647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.26600647 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.57299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.07299805 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.75500488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.25500488 27.3220005 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.53300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.03300476 27.3220005 Tm [(tr)1(ansm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(embrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.35100174 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.85100174 42.92200089 Tm [(regions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.97899628 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.47899628 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.7559967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.2559967 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.81700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.31700134 42.92200089 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.13800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.63800049 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.90600586 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.40600586 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.40699768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.90699768 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.31700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.81700134 42.92200089 Tm [(surfa)1(c)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.84599304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.34599304 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.34500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.84500122 42.92200089 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.51900005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.01900005 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.41500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.91500092 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.91600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.41600037 58.52199936 Tm [(CD4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.56999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.06999969 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.3769989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.8769989 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.95200348 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.45200348 58.52199936 Tm [(supp)1(ort)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.17100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.67100525 58.52199936 Tm [(HIV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.36399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.86399841 58.52199936 Tm [(en)-1(t)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.07000732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.57000732 58.52199936 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.58599854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.08599854 58.52199936 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.66200256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.16200256 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.36400032 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.86400032 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.12099838 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.62099838 74.12200165 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.01499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51499939 74.12200165 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.66899872 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.16899872 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.11000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.61000061 74.12200165 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.39500427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.89500427 74.12200165 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.98500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.48500061 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.227005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.727005 74.12200165 Tm [(Mutat)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ons)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.43400002 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.93400002 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.875 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.375 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.83100128 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.33100128 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.84700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.34700012 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.69400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.19400024 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.7009964 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.20100403 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.32800293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.82800293 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.22399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.72399902 89.72200012 Tm [(WHIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.28199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.78199768 89.72200012 Tm [(\(wa)1(rts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 105.3219986 Tm [(hypo)1(gammag)1(lobuline)-1(mia,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.59300232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.09300232 105.3219986 Tm [(infec)-1(t)1(i)-1(o)1(ns,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.12199402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.62199402 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.89900208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.39900208 105.3219986 Tm [(mye)-1(lokat)1(hexis\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.82299805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(syndrome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.09700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.59700012 120.92199707 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.2009964 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.7009964 120.92199707 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.65499878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.15499878 120.92199707 Tm [(splice)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.47900391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.97900391 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.71499634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.21499634 120.92199707 Tm [(en)-1(cod)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.74300003 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.24300003 136.52200317 Tm [(isof)1(orms,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.56999969 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.06999969 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.41699982 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.91699982 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.42399597 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.92399597 136.52200317 Tm [(chara)1(c)-1(terized.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.62399292 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 0.75 m 155.1499939 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 141.8999939 m 155.1499939 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.875 m 423.17498779 157.875 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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