%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 127 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(BDH1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 106.40499878 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 216.84500122 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 227.84500122 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -35.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -11.875 61.9640007 Tm [(BDH1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 14.78500366 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 67.28500366 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.53500366 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BDH1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.76899719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.14299774 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.79299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.16700745 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.72599792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.1000061 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.89599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BDH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.52300262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.89700317 12.82499981 Tm [(SD)-1(R9C1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.125 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BDH1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.03500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 167.92500305 0.75 l 167.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 168.92500305 -0.25 l 168.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 168.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 168.67500305 156.75 l h f* Q q 1 0 0 1 168.30000305 0 cm -0.625 -0.25 m 255.125 -0.25 l 255.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(sho)1(rt-)1(c)-1(ha)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36000061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.86000061 11.72200012 Tm [(dehy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(dr)1(ogenase/)-1(reductas)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.375 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.875 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.39099884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.89099884 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.63900757 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.44599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.94599915 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.45300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.95300293 27.3220005 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 42.92200089 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.92300034 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.42300034 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.39799881 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.89799881 42.92200089 Tm [(ho)1(motetra)1(me)-1(ric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.4240036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.9240036 42.92200089 Tm [(lipid-)1(requirin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.88200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.38200378 42.92200089 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.76300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.26300049 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.10499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.60499573 42.92200089 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 58.52199936 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.33100128 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.83100128 58.52199936 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.61499786 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.11500549 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.39199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.89199829 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.57400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.07400513 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.04899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.54899597 58.52199936 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.5059967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.0059967 58.52199936 Tm [(requir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(eme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.54500008 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.04499817 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.32300186 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.82300186 74.12200165 Tm [(ph)1(osph)1(atid)1(y)-1(lcholine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14700317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.64700317 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.92500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.42500305 74.12200165 Tm [(op)1(timal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.44599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.94599915 74.12200165 Tm [(en)-1(z)1(y)-1(ma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.45599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.63800049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.13800049 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.94499969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.44499969 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.95200348 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.45200348 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.75900269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.25900269 89.72200012 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.93099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.43099976 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.43200684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.93200684 89.72200012 Tm [(interc)-1(o)1(n)-1(v)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.82900047 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.32900047 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.17099953 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.67100143 105.3219986 Tm [(ace)-1(t)1(oacetat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.72100067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.22100067 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.4980011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.9980011 105.3219986 Tm [(\(R\)-)1(3)-1(-)1(hydroxybut)1(y)-1(r)1(ate,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.94299316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.44299316 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.44400024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.94400024 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(wo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 120.92199707 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.29800034 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.79800034 120.92199707 Tm [(ke)-1(t)1(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.53099823 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.03099823 120.92199707 Tm [(bo)1(die)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.92500305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.42500305 120.92199707 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.00999451 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.50999451 120.92199707 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.94700623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.44700623 120.92199707 Tm [(fa)1(tty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01100159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.51100159 120.92199707 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.15100098 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.65100098 120.92199707 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(at)1(abo)1(l)-1(ism.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.32799911 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.82799911 136.52200317 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.70899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.20899963 136.52200317 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.28999329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.78999329 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.71200562 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.21200562 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.78199768 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.28199768 136.52200317 Tm [(en)-1(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.45499992 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.95499992 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.95600128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.45600128 152.12199402 Tm [(same)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.13600159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.63600159 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.94300079 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.44300079 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.79000092 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.28999329 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.79699707 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.29699707 152.12199402 Tm [(described.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.44900513 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 167.92500305 0.75 l 167.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 168.92500305 -0.25 l 168.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 168.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 168.67500305 16.35000038 l h f* Q q 1 0 0 1 168.30000305 0 cm -0.625 -0.25 m 255.125 -0.25 l 255.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.30000305 0.75 m 168.30000305 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 168.30000305 157.5 m 168.30000305 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>