%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 150 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 25.63199997 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 75.30799866 23.67700005 Tm 0 Tr [(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.66999817 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.64399719 23.67700005 Tm [(\(Ph)1(osph)1(o-Tyr177\))] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 279.22698975 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 389.66699219 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.63600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.01000214 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr1)1(77\))] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 182.24299622 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 234.74299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.49299622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.74500275 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.1190033 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr1)1(77\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.352005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.72599792 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.37600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.75 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.30900574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.68299866 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.47900391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ALL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.71399689 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.08799744 12.82499981 Tm [(CML)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.88800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.26200104 12.82499981 Tm [(PHL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.45200348 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.82600403 12.82499981 Tm [(BCR1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.96899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.34300232 12.82499981 Tm [(D22S11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.72399902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.0980072 12.82499981 Tm [(D22S662)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.99099731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.01100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.38500214 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr1)1(77\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.61799622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 179.17500305 0.75 l 179.17500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 180.17500305 -0.25 l 180.17500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 179.92500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 179.92500305 172.3500061 l h f* Q q 1 0 0 1 179.55000305 0 cm -0.625 -0.25 m 243.875 -0.25 l 243.875 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 11.72200012 Tm [(rec)-1(ip)1(roc)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.07300186 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.57300186 11.72200012 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.66899872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.16899872 11.72200012 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.24099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.74099731 11.72200012 Tm [(chromos)1(ome)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.70199585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.20199585 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.55500031 27.3220005 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.83300018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.33300018 27.3220005 Tm [(pro)1(duc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.32800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.82800293 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.82900238 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.32900238 27.3220005 Tm [(Philad)1(e)-1(lp)1(hia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.05900574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.55900574 27.3220005 Tm [(chromos)1(ome)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.52000427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.02000427 27.3220005 Tm [(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(hich)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.99099922 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.49099922 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.05200005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.55199814 42.92200089 Tm [(of)1(ten)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.39899826 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.89899826 42.92200089 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.58899689 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.08899689 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.02999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.52999878 42.92200089 Tm [(pa)1(tien)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.17199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.67199707 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.06799316 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.56799316 42.92200089 Tm [(chronic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.23500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.73500061 42.92200089 Tm [(mye)-1(log)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(en)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08600044 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.58600044 58.52199936 Tm [(leu)-1(ke)-1(mia)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.60900116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.10900116 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.91600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.41600037 58.52199936 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.21099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.71099854 58.52199936 Tm [(22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.26699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.76699829 58.52199936 Tm [(breakpo)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.69599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.19599915 58.52199936 Tm [(fo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.39299965 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.89299965 74.12200165 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.98899841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.48899841 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.05000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.55000305 74.12200165 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.3710022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.8710022 74.12200165 Tm [(wit)1(hin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.20700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.70700073 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.70799255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.20799255 74.12200165 Tm [(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.75100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.25100708 74.12200165 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.93299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 89.72200012 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.40299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.90299988 89.72200012 Tm [(pro)1(duc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.89800262 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.39800262 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3730011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.8730011 89.72200012 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.36799622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.86799622 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.17500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.67500305 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.77200317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.27200317 89.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.17300034 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.67300034 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.18500137 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.68499756 105.3219986 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.53199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.03199768 105.3219986 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.74299622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.24299622 105.3219986 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.60699463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.10699463 105.3219986 Tm [(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.6499939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.1499939 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.42700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.92700195 105.3219986 Tm [(ABL,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.69200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.19200134 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.66400146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.16400146 120.92199707 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.49200058 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.99200058 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.99299622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.49299622 120.92199707 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.28799438 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.78799438 120.92199707 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.06599426 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.56599426 120.92199707 Tm [(breakpo)1(i)-1(nt)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.66200256 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.16200256 120.92199707 Tm [(Alt)1(houg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.04299927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54299927 136.52200317 Tm [(BCR-A)1(B)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.57800293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.07800293 136.52200317 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.57299805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.07299805 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.38000488 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.88000488 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.56199646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.06199646 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.56900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.06900024 136.52200317 Tm [(extensive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.29299927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(st)1(u)-1(d)1(ie)-1(d)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.24700165 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.74700165 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.7480011 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.2480011 152.12199402 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.98899841 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.48899841 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.33100128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.83100128 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.83200073 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.33200073 152.12199402 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.83900452 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.33900452 152.12199402 Tm [(BCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.88200378 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.38200378 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.897995 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.397995 152.12199402 Tm [(pro)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(uc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.4119997 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.91200066 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.47299957 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.97299957 167.72200012 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.59400177 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.09400177 167.72200012 Tm [(cl)-1(ear.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.68599701 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.18599701 167.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.99299622 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.49299622 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.80000305 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.30000305 167.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.98199463 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.48199463 167.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.83599854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.33599854 167.72200012 Tm [(ki)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 179.55000305 0.75 m 179.55000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>