%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 141 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.3710022 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.04699707 23.67700005 Tm 0 Tr [(CXCR1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.48899841 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.9289856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CXCR1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.91999817 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.41999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.91999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CXCR1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.40399933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.77799988 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.80200195 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.36099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.73500061 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.53100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C-C)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.22100067 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.59500122 12.82499981 Tm [(CD128;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.4280014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.80200195 12.82499981 Tm [(CD181;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.00900269 12.82499981 Tm [(CKR-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.11000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.48399353 12.82499981 Tm [(IL8R1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.69799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.07200623 12.82499981 Tm [(IL8RA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.03999329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.41400146 12.82499981 Tm [(CMKA)1(R1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.35299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.72698975 12.82499981 Tm [(IL8RBA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.40600586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.77999878 12.82499981 Tm [(CDw128a;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 358.14898682 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.52301025 12.82499981 Tm [(C-C)-1(-CK)1(R-)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 403.44100952 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CXCR1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66999817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 162.2749939 0.75 l 162.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 163.2749939 -0.25 l 163.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 163.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 163.0249939 172.3500061 l h f* Q q 1 0 0 1 162.6499939 0 cm -0.625 -0.25 m 260.7749939 -0.25 l 260.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(G-)1(prot)1(ei)-1(n-)1(c)-1(oup)1(l)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.5739975 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.0739975 27.3220005 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.4960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.9960022 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.2440033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.7440033 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.0059967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.5059967 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.81300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.31300354 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.87399292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.37399292 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.34899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.84899902 27.3220005 Tm [(rec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(epto)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.36599922 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.86599922 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.14400101 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.64400101 42.92200089 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.3690033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.8690033 42.92200089 Tm [(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.14700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.64700317 42.92200089 Tm [(\(IL8)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36699677 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86700439 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.86599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.36599731 42.92200089 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.97799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.47799683 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05299377 42.92200089 Tm [(IL8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.59500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.09500122 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.49099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.99099731 42.92200089 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.22599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.72599792 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ff)1(in)-1(it)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.85899925 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.35899925 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.63600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.13600159 58.52199936 Tm [(tr)1(ansduc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.69999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.19999695 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.2009964 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.7009964 58.52199936 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.93400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.43400574 58.52199936 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.33099365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.83099365 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.80599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.30599976 58.52199936 Tm [(G-)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.19900513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.69900513 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ctivat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.17599869 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.67599869 74.12200165 Tm [(sec)-1(o)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.48600006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.98600006 74.12200165 Tm [(messe)-1(ng)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.80999756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.30999756 74.12200165 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.46499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.96499634 74.12200165 Tm [(Knock)-1(o)1(u)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.97900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.47900391 74.12200165 Tm [(st)1(u)-1(d)1(ie)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.96800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.46800232 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.40899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mic)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.44799995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.94799995 89.72200012 Tm [(sugg)1(e)-1(st)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.66200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.16200256 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.38400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.88400269 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.83999634 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.14700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.64700317 89.72200012 Tm [(inhibits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.18699646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.68699646 89.72200012 Tm [(embryonic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.35099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.85099792 89.72200012 Tm [(oli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(go)1(den)-1(d)1(rocy)-1(t)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.53900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.03900146 105.3219986 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.15000153 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.65000153 105.3219986 Tm [(migra)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.66200256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.16200256 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.10299683 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.60299683 105.3219986 Tm [(developing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.85899353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.35899353 105.3219986 Tm [(spinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.58399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(cord.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.59499931 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.09499931 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.35699844 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.85699844 120.92199707 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.53900146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.03900146 120.92199707 Tm [(IL8)-1(R)1(B)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26999664 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.76999664 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.74500275 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.24500275 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.76100159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.26100159 120.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.60299683 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10299683 120.92199707 Tm [(anot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.78300476 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.28300476 120.92199707 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.51800537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(af)1(fini)-1(t)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.66699982 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.16699982 136.52200317 Tm [(IL8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.70899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.20899963 136.52200317 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.79699707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.29699707 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.43800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.93800354 136.52200317 Tm [(well)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.94000244 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.44000244 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.58099365 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.08099365 136.52200317 Tm [(IL8)-1(R)1(B)-1(P,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.81799316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.31799316 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.29299927 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.79299927 136.52200317 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.35400391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.85400391 136.52200317 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 152.12199402 Tm [(IL8)-1(R)1(B)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.85100174 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.35100174 152.12199402 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.06200027 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.56200027 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.53700256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.03700256 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5530014 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.0530014 152.12199402 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.56900024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.06900024 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.00999451 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.50999451 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.48500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.98500061 152.12199402 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.94700623 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.44700623 152.12199402 Tm [(map)1(ped)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.21400452 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.71400452 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.78900146 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.28900146 152.12199402 Tm [(ch)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(romo)1(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.74000168 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.24000168 167.72200012 Tm [(2q3)-1(3-q)1(3)-1(6.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.20300293 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 162.6499939 0.75 m 162.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>