%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 133 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.33699799 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 141.01300049 23.67700005 Tm 0 Tr [(CXCL12)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.522995 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.9630127 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CXCL)-1(12)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.95500183 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.45500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.70500183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CXCL12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.43800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.81199646 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46200562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.83599854 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.39500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.76899719 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.56500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IRH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.69799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.0719986 12.82499981 Tm [(PBSF;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.66600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.04000092 12.82499981 Tm [(SD)-1(F1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.27999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.65400696 12.82499981 Tm [(TL)-1(SF)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.64399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.01800537 12.82499981 Tm [(SD)-1(F1A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.33399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.70799255 12.82499981 Tm [(SD)-1(F1B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.66000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.03399658 12.82499981 Tm [(TPAR)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.48300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.85699463 12.82499981 Tm [(SC)-1(YB12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.75201416 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CXCL)-1(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.70500183 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 154.0249939 125.55000305 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(st)1(romal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.1499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.6499939 11.72200012 Tm [(ce)-1(ll-d)1(e)-1(rived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.73500061 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.3690033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.8690033 11.72200012 Tm [(che)-1(mo)1(k)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.86999893 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.36999893 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.2120018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.7120018 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.71299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.21299744 27.3220005 Tm [(interc)-1(r)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.04699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.54699707 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.29499817 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.05700684 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.57299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.07299805 27.3220005 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.147995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.647995 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.17099953 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.67099953 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.0929985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.59300232 42.92200089 Tm [(CXCR4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.59300232 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.09300232 42.92200089 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.1269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.6269989 42.92200089 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.02099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.52099609 42.92200089 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.02600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.52600098 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.80299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.30299377 42.92200089 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.6499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.50699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.00699997 58.52199936 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.07700348 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.57700348 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.51799774 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.01799774 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.01899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.51899719 58.52199936 Tm [(metast)1(asis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.60699463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.10699463 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.94900513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.44900513 58.52199936 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.87600708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.37600708 58.52199936 Tm [(canc)-1(ers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.63200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.13200378 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.89900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 74.12200165 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.42599869 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.92599869 74.12200165 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.18199921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.68199921 74.12200165 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.53099823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.03100586 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.97200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.47200012 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.92799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.42799377 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.94400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.44400024 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.96200562 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.46200562 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.58900452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.08900452 74.12200165 Tm [(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ith)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.28999996 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.78999996 89.72200012 Tm [(resista)1(n)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.5530014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.0530014 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.12799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.62799835 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.66899872 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.16899872 89.72200012 Tm [(immun)-1(o)1(defic)-1(ienc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.46000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.96000671 89.72200012 Tm [(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.22799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.72799683 89.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.69900513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.19900513 89.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.477005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.977005 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(fec)-1(t)1(ions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.08800125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.58800125 105.3219986 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.31999969 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.81999969 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.74199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.24199677 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.81199646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.31199646 105.3219986 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.65400696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.15400696 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.09399414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.59399414 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(of)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.59900093 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.09899902 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.44599915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.94599915 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.45300293 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.95300293 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.64299774 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14299774 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.42100525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.92100525 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.3769989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.8769989 120.92199707 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.55900574 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CXCL1)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.02099991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CXCL1)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.88400269 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 0.75 m 153.6499939 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 126.30000305 m 153.6499939 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 142.65000916 m 153.6499939 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 159.00001526 m 153.6499939 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>