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[<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CUL5)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 100.8219986 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 153.32200623 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 163.82200623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CU)1(L)-1(5)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 105.80500031 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 108.17900085 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 133.82899475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 136.20300293 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 179.76199341 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 182.13600159 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 219.93200684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cul)-1(li)-1(n)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 85.70200348 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 88.0759964 12.82499981 Tm [(5;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 96.20700073 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 98.58100128 12.82499981 Tm [(CUL-5;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 126.67700195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 129.05099487 12.82499981 Tm [(VACM1;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 163.79100037 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 166.16499329 12.82499981 Tm [(VACM-1)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 201.30999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CUL5)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 85.0719986 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 79 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 152.92500305 0.75 l 152.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 153.92500305 -0.25 l 153.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 153.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 153.67500305 172.3500061 l h f* Q q 1 0 0 1 153.30000305 0 cm -0.625 -0.25 m 270.125 -0.25 l 270.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Core)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 20.28499985 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 24.78499985 11.72200012 Tm [(component)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 74.47399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 78.97399902 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 87.81600189 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 92.31600189 11.72200012 Tm [(multiple)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 127.68800354 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 132.18800354 11.72200012 Tm [(SCF-lik)-1(e)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 166.87399292 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 171.37399292 11.72200012 Tm [(ECS)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 187.53700256 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 192.03700256 11.72200012 Tm [(\(Elongin-)1(Cu)-1(llin)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 255.54200745 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(2/)-1(5-SOCS-b)1(ox)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 61.96300125 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 66.46299744 27.3220005 Tm [(pro)1(tein)-1(\))] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 100.77500153 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 105.27500153 27.3220005 Tm [(E3)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 115.50099945 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 120.00099945 27.3220005 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 193.88200378 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 198.38200378 27.3220005 Tm [(ligas)1(e)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 223.17599487 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 227.67599487 27.3220005 Tm [(comple)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(xes,)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 16 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 20.5 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 45.59700012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 50.09700012 42.92200089 Tm [(mediat)1(e)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 85.22200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 89.72200012 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 103.72299957 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 108.22299957 42.92200089 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 168.89399719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 173.39399719 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 189.67100525 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 194.17100525 42.92200089 Tm [(subsequent)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 244.21200562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 248.71200562 42.92200089 Tm [(pr)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ot)1(e)-1(a)1(somal)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 44.84600067 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 49.34600067 58.52199936 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 102.12400055 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 106.62400055 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 115.46600342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 119.96600342 58.52199936 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 145.94599915 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 150.44599915 58.52199936 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 188.08500671 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 192.58500671 58.52199936 Tm [(As)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 203.08399963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 207.58399963 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 212.55900574 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 217.05900574 58.52199936 Tm [(scaff)1(old)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 250.82699585 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 255.32699585 58.52199936 Tm [(p)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rot)1(e)-1(in)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 25.55900002 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 30.05900002 74.12200165 Tm [(may)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 48.22999954 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 52.72999954 74.12200165 Tm [(contribut)1(e)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 97.4489975 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 101.9489975 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 111.02400208 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 115.52400208 74.12200165 Tm [(cata)1(l)-1(ysis)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 151.2250061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 155.7250061 74.12200165 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 190.62199402 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 195.12199402 74.12200165 Tm [(po)1(sitioning)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 243.86599731 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 248.36599731 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 257.20800781 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 14.0010004 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 18.50099945 89.72200012 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 58.35100174 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 62.85100174 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 79.12799835 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 83.62799835 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 97.6289978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 102.1289978 89.72200012 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 196.21600342 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 200.71600342 89.72200012 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 236.26300049 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 240.76300049 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 256.57000732 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 43.11000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 47.61000061 105.3219986 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 90.07900238 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 94.57900238 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 103.42099762 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 107.92099762 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 121.92199707 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 126.42199707 105.3219986 Tm [(E3)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 136.647995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 141.147995 105.3219986 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 215.02900696 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 219.52900696 105.3219986 Tm [(ligas)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 244.32299805 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 248.82299805 105.3219986 Tm [(co)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mplex)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 26.24399948 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 30.74399948 120.92199707 Tm [(depends)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 67.93099976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 72.43099976 120.92199707 Tm [(on)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 83.6989975 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 88.1989975 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 102.19999695 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 106.69999695 120.92199707 Tm [(var)1(i)-1(a)1(ble)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 140.45399475 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 144.95399475 120.92199707 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 184.80400085 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 189.30400085 120.92199707 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 238.79499817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 243.29499817 120.92199707 Tm [(com)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(po)1(n)-1(ent.)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 33.18799973 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 37.68799973 136.52200317 Tm [(ECS\(SOCS1\))] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 88.88400269 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 93.38400269 136.52200317 Tm [(see)-1(ms)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 120.36199951 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 124.86199951 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 133.93699646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 138.43699646 136.52200317 Tm [(direct)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 162.9980011 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 167.4980011 136.52200317 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 228.16900635 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 232.66900635 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 241.51100159 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 246.01100159 136.52200317 Tm [(JAK)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(2.)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 7.44399977 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 11.94400024 152.12199402 Tm [(Se)-1(ems)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 39.95000076 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 44.45000076 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 53.52500153 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 58.02500153 152.12199402 Tm [(be)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 68.8789978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 73.3789978 152.12199402 Tm [(involved)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 109.7480011 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 114.2480011 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 122.18900299 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 126.68900299 152.12199402 Tm [(pro)1(teosoma)1(l)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 181.46699524 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 185.96699524 152.12199402 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 238.74499512 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 243.24499512 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 252.08700562 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(p53)-1(/TP53)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 41.36999893 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 45.86999893 167.72200012 Tm [(st)1(i)-1(mulat)1(e)-1(d)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 91.34899902 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 95.84899902 167.72200012 Tm [(by)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 106.36100006 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 110.86100006 167.72200012 Tm [(ad)1(e)-1(novirus)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 158.23399353 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 162.73399353 167.72200012 Tm [(E1B)-1(-)1(5)-1(5)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 193.05599976 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 197.55599976 167.72200012 Tm [(kDa)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 214.28599548 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 218.78599548 167.72200012 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 252.25900269 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.30000305 0.75 m 153.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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