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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.94599915 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.62199402 23.67700005 Tm 0 Tr [(CUL4A)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.91299438 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.35299683 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CUL4A)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.39700317 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.89700317 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 180.39700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CU)1(L)-1(4A)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 111.87999725 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 114.2539978 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 139.90400696 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 142.27799988 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 185.83700562 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 188.21099854 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 226.00700378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CUL4A)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 91.14700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110025000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 147 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 149.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 168 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 170.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <</MCID 72 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 76 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 149.17500305 203.55000305 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CUL4A)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 28.96899986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 33.46900177 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 40.02999878 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 44.52999878 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 58.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 63.03099823 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 101.71199799 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 106.21199799 11.72200012 Tm [(ligase)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 131.0059967 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 135.5059967 11.72200012 Tm [(component)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 185.19500732 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 189.69500732 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 198.53700256 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 203.03700256 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 208.01199341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 212.51199341 11.72200012 Tm [(multimeric)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 258.51800537 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(complex)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 36.47900009 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 40.97900009 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 77.34799957 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 81.84799957 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 89.78900146 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 94.28900146 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 108.29000092 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 112.79000092 27.3220005 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 165.56799316 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 170.06799316 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 178.91000366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 183.41000366 27.3220005 Tm [(DNA)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 203.91499329 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 208.41499329 27.3220005 Tm [(da)1(mage-resp)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(onse)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 20.54000092 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 25.04000092 42.92200089 Tm [(pro)1(tein)-1(s)1(.Core)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 82.96399689 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 87.46399689 42.92200089 Tm [(component)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 137.15299988 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 141.65299988 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 150.49499512 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 154.99499512 42.92200089 Tm [(multiple)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 190.36700439 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 194.86700439 42.92200089 Tm [(cu)-1(llin-RING)1(-ba)1(s)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ed)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 10.86299992 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 15.36299992 58.52199936 Tm [(E3)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 25.5890007 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 30.0890007 58.52199936 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 103.97000122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 108.47000122 58.52199936 Tm [(ligase)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 133.26400757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 137.76400757 58.52199936 Tm [(complexe)-1(s)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 183.51499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 188.01499939 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 213.11199951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 217.61199951 58.52199936 Tm [(mediat)1(e)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 252.73699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 257.23699951 58.52199936 Tm [(th)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 70.27700043 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 74.77700043 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 91.05400085 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 95.55400085 74.12200165 Tm [(subsequen)-1(t)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 145.59500122 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 150.09500122 74.12200165 Tm [(pro)1(teasoma)1(l)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 204.12600708 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 208.62600708 74.12200165 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 261.4039917 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 8.84200001 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 13.34200001 89.72200012 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 39.3219986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 43.8219986 89.72200012 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 81.46099854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 85.96099854 89.72200012 Tm [(As)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 96.45999908 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 100.95999908 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 105.93499756 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 110.43499756 89.72200012 Tm [(scaff)1(old)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 144.20300293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 148.70300293 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 180.00999451 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 184.50999451 89.72200012 Tm [(may)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 202.68099976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 207.18099976 89.72200012 Tm [(contribut)1(e)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 251.8999939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 256.3999939 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 265.4750061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(cata)1(l)-1(ysis)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 35.70100021 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 40.20100021 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 75.09799957 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 79.59799957 105.3219986 Tm [(po)1(sitioning)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 128.34199524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 132.84199524 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 141.68400574 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 146.18400574 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 160.18499756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 164.68499756 105.3219986 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 204.53500366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 209.03500366 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 225.31199646 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 229.81199646 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 243.81300354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 248.31300354 105.3219986 Tm [(ubi)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(quitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 80.39800262 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 84.89800262 120.92199707 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 120.44499969 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 124.94499969 120.92199707 Tm [(The)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 140.7519989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 145.2519989 120.92199707 Tm [(E3)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 155.47799683 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 159.97799683 120.92199707 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 233.85899353 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 238.35899353 120.92199707 Tm [(ligase)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 263.15301514 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 30.47200012 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 34.97200012 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 43.81399918 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 48.31399918 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 62.31499863 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 66.81500244 136.52200317 Tm [(complex)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 103.29399872 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 107.79399872 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 114.35500336 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 118.85500336 136.52200317 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 165.8809967 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 170.3809967 136.52200317 Tm [(on)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 181.64900208 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 186.14900208 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 200.1499939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 204.6499939 136.52200317 Tm [(ne)-1(d)1(dylatio)1(n)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 255.96499634 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 260.46499634 136.52200317 Tm [(o)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(f)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 3.11999989 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 7.61999989 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 21.62100029 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 26.12100029 152.12199402 Tm [(cu)-1(llin)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 48.9109993 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 53.4109993 152.12199402 Tm [(subunit)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 85.71099854 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 90.21099854 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 106.48799896 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 110.98799896 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 117.5490036 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 122.0490036 152.12199402 Tm [(inhibited)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 160.28599548 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 164.78599548 152.12199402 Tm [(by)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 175.29800415 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 179.79800415 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 193.79899597 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 198.29899597 152.12199402 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 246.22599792 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 250.72599792 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 259.56799316 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 14.0010004 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 18.50099945 167.72200012 Tm [(dene)-1(d)1(dylated)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 77.87999725 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 82.37999725 167.72200012 Tm [(cu)-1(llin)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 105.16999817 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 109.66999817 167.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 141.97000122 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 146.47000122 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 164.86599731 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 169.36599731 167.72200012 Tm [(TIP12)-1(0A/CAND)1(1)-1(.)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 242.65800476 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 247.15800476 167.72200012 Tm [(The)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 262.96499634 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(func)-1(t)1(ional)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 43.11000061 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 47.61000061 183.32200623 Tm [(speci)-1(f)1(ic)-1(it)1(y)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 90.07900238 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 94.57900238 183.32200623 Tm [(of)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 103.42099762 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 107.92099762 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 121.92199707 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 126.42199707 183.32200623 Tm [(E3)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 136.647995 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 141.147995 183.32200623 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 215.02900696 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 219.52900696 183.32200623 Tm [(ligas)1(e)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 244.32299805 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 248.82299805 183.32200623 Tm [(co)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 0 198.92199707 Tm [(mplex)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 26.24399948 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 30.74399948 198.92199707 Tm [(depends)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 67.93099976 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 72.43099976 198.92199707 Tm [(on)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 83.6989975 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 88.1989975 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 102.19999695 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 106.69999695 198.92199707 Tm [(var)1(i)-1(a)1(ble)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 140.45399475 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 144.95399475 198.92199707 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 184.80400085 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 189.30400085 198.92199707 Tm [(rec)-1(o)1(gnition)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 238.79499817 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 243.29499817 198.92199707 Tm [(com)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 0.75 m 148.80000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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