%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<</Author(\376\377\\\017QlN;)/Creator(Aspose Ltd.)/Producer(Aspose.PDF for .NET 19.2)/CreationDate(D:20200601032800Z)/ModDate(D:20200731151233+08'00')>>
endobj
2 0 obj
<</Type/Catalog/Pages 3 0 R/Lang(en-US)/StructTreeRoot 39 0 R/MarkInfo<</Marked true>>/Metadata 133 0 R>>
endobj
3 0 obj
<</Type/Pages/Count 2/Kids[4 0 R 35 0 R]>>
endobj
4 0 obj
<</Type/Page/Parent 3 0 R/Contents 5 0 R/MediaBox[0 0 595.29998779 841.90002441]/Resources<</Font<</FAAAAH 7 0 R/FAAABB 11 0 R/FAAABG 16 0 R/FAAABJ 19 0 R/FAAACF 25 0 R/FAAACJ 29 0 R/FAAADC 32 0 R>>/ExtGState<</GS1 18 0 R/GS2 23 0 R>>/XObject<</X1 9 0 R>>>>/Group<</Type/Group/S/Transparency/CS/DeviceRGB>>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<</Length 24851>>stream
1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 101.61199951 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 151.28799438 23.67700005 Tm 0 Tr [(CUL2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 203.2480011 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 313.68798828 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CUL2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.3219986 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 163.82200623 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 174.32200623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CU)1(L)-1(2)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 105.80500031 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 108.17900085 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 133.82899475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 136.20300293 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 179.76199341 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 182.13600159 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 219.93200684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CUL2)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 85.0719986 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110025000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <</MCID 68 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 182.17500305 0.75 l 182.17500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 183.17500305 -0.25 l 183.17500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 72 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 182.92500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 182.92500305 203.55000305 l h f* Q q 1 0 0 1 182.55000305 0 cm -0.625 -0.25 m 240.875 -0.25 l 240.875 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 74 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(ma)1(n)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 31.45999908 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 35.95999908 11.72200012 Tm [(CUL2)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 58.59600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 63.09600067 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 69.65699768 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 74.15699768 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 84.6780014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 89.1780014 11.72200012 Tm [(ort)1(holo)1(g)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 126.8259964 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 131.32600403 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 140.16799927 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 144.66799927 11.72200012 Tm [(ne)-1(ma)1(tod)1(e)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 188.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 193.16600037 11.72200012 Tm [(cu)-1(l2.)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 213.06399536 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 217.56399536 11.72200012 Tm [(Mi)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(che)-1(l)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 17.55599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 22.05599976 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 38.33300018 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 42.83300018 27.3220005 Tm [(Xiong)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 68.05799866 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 72.55799866 27.3220005 Tm [(\(19)-1(98)-1(\))] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 99.68099976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 104.18099976 27.3220005 Tm [(identified)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 145.11199951 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 149.61199951 27.3220005 Tm [(human)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 179.65299988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 184.15299988 27.3220005 Tm [(CUL2)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 206.78900146 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 211.28900146 27.3220005 Tm [(cDN)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(As)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 10.4989996 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 14.9989996 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 31.27599907 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 35.77600098 42.92200089 Tm [(repor)1(ted)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 73.44200134 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 77.94200134 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 95.16400146 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 99.66400146 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 113.66500092 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 118.16500092 42.92200089 Tm [(predicted)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 159.33700562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 163.83700562 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 195.14399719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 199.64399719 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 206.20500183 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 210.70500183 42.92200089 Tm [(74)-1(5)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 226.53799438 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(amino)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 27.06999969 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 31.56999969 58.52199936 Tm [(acids)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 53.37599945 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 57.87599945 58.52199936 Tm [(long.)1(Core)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 99.74700165 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 104.24700165 58.52199936 Tm [(component)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 153.93600464 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 158.43600464 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 167.27799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 171.77799988 58.52199936 Tm [(multiple)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 207.1499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 211.6499939 58.52199936 Tm [(cu)-1(lli)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n-RING)1(-ba)1(se)-1(d)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 61.61600113 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 66.11599731 74.12200165 Tm [(ECS)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 82.27899933 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 86.77899933 74.12200165 Tm [(\(ElonginB/)-1(C)1(-CUL2/5)-1(-SOCS-)1(box)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 220.82099915 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 225.32099915 74.12200165 Tm [(p)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(rot)1(e)-1(in\))] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 28.56399918 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 33.06399918 89.72200012 Tm [(E3)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 43.29000092 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 47.79000092 89.72200012 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 121.67099762 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 126.17099762 89.72200012 Tm [(ligas)1(e)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 150.96499634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 155.46499634 89.72200012 Tm [(complexe)-1(s)1(,)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 203.38299561 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 207.88299561 89.72200012 Tm [(wh)1(ic)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(h)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 5.54199982 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 10.04199982 105.3219986 Tm [(mediat)1(e)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 45.16699982 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 49.66699982 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 63.66799927 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 68.16799927 105.3219986 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 128.83900452 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 133.33900452 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 142.18099976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 146.68099976 105.3219986 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 172.66099548 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 177.16099548 105.3219986 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 214.80000305 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 219.30000305 105.3219986 Tm [(M)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ay)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 9.73799992 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 14.23799992 120.92199707 Tm [(serve)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 36.77799988 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 41.27799988 120.92199707 Tm [(as)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 50.41899872 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 54.91899872 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 59.89400101 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 64.39399719 120.92199707 Tm [(rigid)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 84.13400269 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 88.63400269 120.92199707 Tm [(scaff)1(old)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 122.40200043 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 126.90200043 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 134.84300232 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 139.34300232 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 153.34399414 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 157.84399414 120.92199707 Tm [(complex)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 194.32299805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 198.82299805 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 215.1000061 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 219.6000061 120.92199707 Tm [(m)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ay)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 9.73799992 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 14.23799992 136.52200317 Tm [(contribut)1(e)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 58.95700073 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 63.45700073 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 72.53199768 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 77.03199768 136.52200317 Tm [(cata)1(l)-1(ysis)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 112.73300171 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 117.23300171 136.52200317 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 152.13000488 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 156.63000488 136.52200317 Tm [(po)1(sitioning)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 205.37399292 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 209.87399292 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 218.71600342 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 223.21600342 136.52200317 Tm [(th)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(e)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 5.10599995 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 9.60599995 152.12199402 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 49.45600128 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 53.95600128 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 70.23300171 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 74.73300171 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 88.73400116 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 93.23400116 152.12199402 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 187.32099915 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 191.82099915 152.12199402 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 227.36799622 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(The)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 15.80700016 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 20.30699921 167.72200012 Tm [(E3)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 30.53300095 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 35.03300095 167.72200012 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 108.91400146 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 113.41400146 167.72200012 Tm [(ligase)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 138.20799255 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 142.70799255 167.72200012 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 173.17999268 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 177.67999268 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 186.52200317 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 191.02200317 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 205.022995 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 209.522995 167.72200012 Tm [(com)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(plex)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 17.81100082 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 22.31100082 183.32200623 Tm [(is)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 28.87199974 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 33.37200165 183.32200623 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 80.39800262 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 84.89800262 183.32200623 Tm [(on)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 96.16600037 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 100.66600037 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 114.66699982 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 119.16699982 183.32200623 Tm [(ne)-1(d)1(dylatio)1(n)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 170.48199463 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 174.98199463 183.32200623 Tm [(of)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 183.82400513 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 188.32400513 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 202.32499695 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 206.82499695 183.32200623 Tm [(cu)-1(llin)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 229.61500549 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 0 198.92199707 Tm [(subunit)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 32.29999924 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 36.79999924 198.92199707 Tm [(and)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 53.07699966 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 57.57699966 198.92199707 Tm [(is)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 64.13800049 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 68.63800049 198.92199707 Tm [(inhibited)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 106.875 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 111.375 198.92199707 Tm [(by)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 121.88700104 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 126.38700104 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 140.38800049 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 144.88800049 198.92199707 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 192.81500244 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 197.31500244 198.92199707 Tm [(of)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 206.15699768 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 210.65699768 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 224.65800476 198.92199707 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 182.55000305 0.75 m 182.55000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 124 0 R/Length 25812>>stream
<a href="http://www.qdhaiyan.cn/">ºÝºÝÈÈÔÚÏßÊÓƵÃâ·Ñ</a>
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<script>
(function(){
    var bp = document.createElement('script');
    var curProtocol = window.location.protocol.split(':')[0];
    if (curProtocol === 'https') {
        bp.src = 'https://zz.bdstatic.com/linksubmit/push.js';
    }
    else {
        bp.src = 'http://push.zhanzhang.baidu.com/push.js';
    }
    var s = document.getElementsByTagName("script")[0];
    s.parentNode.insertBefore(bp, s);
})();
</script>
</body>