%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 123 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 24.07999992 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 73.7559967 23.67700005 Tm 0 Tr [(BCL2\()1(Phos)1(pho)1(-Ser)-1(70\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.7789917 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 280.7789917 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 391.21899414 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(BCL)-1(2)1(\()-1(P)1(h)-1(osph)-1(o-S)-1(e)1(r70\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.26100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 173.51100159 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 226.01100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.26100159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BCL2\(Pho)-1(spho)-1(-Ser7)1(0\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.86999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.2440033 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.89399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.26800537 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.82699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.20100403 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.99700928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Bcl-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.90699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.28099823 12.82499981 Tm [(PP)1(P1R5)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.22000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0011000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BCL)-1(2)1(\()-1(P)1(h)-1(osph)-1(o-S)-1(e)1(r70\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.13600159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001F0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001E0027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 159.67500305 0.75 l 159.67500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 160.67500305 -0.25 l 160.67500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.42500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 160.42500305 109.94999695 l h f* Q q 1 0 0 1 160.05000305 0 cm -0.625 -0.25 m 263.375 -0.25 l 263.375 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.71600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21600342 11.72200012 Tm [(integra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.17900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.67900085 11.72200012 Tm [(outer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.84300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.34300232 11.72200012 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.02600098 11.72200012 Tm [(mem)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(bra)1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.81200027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.31200027 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.61899948 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.1190033 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.34100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.84100342 27.3220005 Tm [(blocks)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.28500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.78500366 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.78599548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.28599548 27.3220005 Tm [(ap)1(opt)1(otic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.81399536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.31399536 27.3220005 Tm [(deat)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.04600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.54600525 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.38800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.88800049 27.3220005 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.31500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.57600021 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.07600021 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.8429985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.3429985 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.48400116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.98400116 42.92200089 Tm [(lymphocytes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.65599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15599823 42.92200089 Tm [(Const)1(itutive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.83599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.33599854 42.92200089 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.28999329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.78999329 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.63200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13200378 42.92200089 Tm [(BC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(L2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.06299973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.56299973 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.33000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.83000183 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.97100067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.47100067 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.41199875 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.91200256 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.91300201 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.41300201 58.52199936 Tm [(case)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.17299652 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.67299652 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.51499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.01499939 58.52199936 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.11099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.61099243 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.45300293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.95300293 58.52199936 Tm [(BCL)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.51699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.01699829 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.09199524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.59199524 58.52199936 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.9940033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.4940033 58.52199936 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(eavy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.56900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.06900024 74.12200165 Tm [(chain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.03900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.53900146 74.12200165 Tm [(locu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.04699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.54699707 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.10800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.60800171 74.12200165 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.42099762 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.92100525 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.9960022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.4960022 74.12200165 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.3500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.8500061 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.85099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.35099792 74.12200165 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.65699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.15699768 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.99899292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.49899292 74.12200165 Tm [(fo)1(l)-1(licul)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 89.72200012 Tm [(lymphoma)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.61399841 89.72200012 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.60099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.10099792 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.02300262 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.522995 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.25900269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.75900269 89.72200012 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.34399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.84399414 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.35600281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.85600281 89.72200012 Tm [(alt)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(at)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.43400002 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.93400002 105.3219986 Tm [(splicin)-1(g)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.51599884 105.3219986 Tm [(dif)1(fe)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.4509964 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.9509964 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.89199829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.39199829 105.3219986 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.22499847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.72499847 105.3219986 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27900696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.77900696 105.3219986 Tm [(en)-1(d)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.52099609 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 159.67500305 0.75 l 159.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.67500305 -0.25 l 160.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 160.42500305 16.35000038 l h f* Q q 1 0 0 1 160.05000305 0 cm -0.625 -0.25 m 263.375 -0.25 l 263.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.62699986 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 159.67500305 0.75 l 159.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 160.67500305 -0.25 l 160.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 160.42500305 16.35000038 l h f* Q q 1 0 0 1 160.05000305 0 cm -0.625 -0.25 m 263.375 -0.25 l 263.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BCL)-1(2\(Pho)1(spho)1(-Ser7)-1(0\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.70899963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 159.67500305 0.75 l 159.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 160.67500305 -0.25 l 160.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 160.42500305 31.95000076 l h f* Q q 1 0 0 1 160.05000305 0 cm -0.625 -0.25 m 263.375 -0.25 l 263.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(serine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.19299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(70)-1(\(R-)1(T)-1(-)1(S\(p\)-P)1(-L\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.25499725 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.75499725 27.3220005 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.03700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.53700256 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.2480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.7480011 27.3220005 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.20799255 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.70799255 27.3220005 Tm [(BCL)-1(-)1(2)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.33200073 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.05000305 0.75 m 160.05000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.05000305 110.69999695 m 160.05000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.05000305 127.04999542 m 160.05000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.05000305 143.3999939 m 160.05000305 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97499084 m 423.17498779 174.97499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>