%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 147 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 110 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(BCKDK)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 117.08300018 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 227.522995 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.772995 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -57.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -33.875 61.9640007 Tm [(BCKDK)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -2.56999969 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 49.92999268 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.17999268 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BCK)1(D)-1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.41400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.78800201 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.43800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.81199646 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.3710022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.74499512 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.54100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BDK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.43599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.80999756 12.82499981 Tm [(BCKDK)1(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.94999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BCKDK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.68000031 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 155.92500305 109.94999695 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(bra)1(nc)-1(hed-)1(c)-1(h)1(ain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.79399872 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.29399872 11.72200012 Tm [(alph)1(a-ketoa)1(c)-1(id)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.54200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.04200745 11.72200012 Tm [(dehydro)1(gen)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.78199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.28199768 11.72200012 Tm [(compl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.66800022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.16800022 27.3220005 Tm [(\(BCKD\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.41600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.91600037 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.47700119 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.97700119 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.4980011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.9980011 27.3220005 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.95899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.45899963 27.3220005 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.18600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.68600464 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.52799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.02799988 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.02900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.52900696 27.3220005 Tm [(valine,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.83700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.33700562 27.3220005 Tm [(leu)-1(cin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.27299976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.77299976 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.04999924 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.54999924 42.92200089 Tm [(isoleuc)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.44100189 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.94100189 42.92200089 Tm [(cata)1(bolic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.52899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.02899933 42.92200089 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.82299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.32299805 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.13000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.63000488 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 42.92200089 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.7689991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.2689991 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.72499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.22499847 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.74099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.24099731 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.30200195 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.99199677 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.49199677 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.43299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.93299866 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.93400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.43400574 58.52199936 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.68200684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.18200684 58.52199936 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.47900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.97900391 58.52199936 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.727005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ph)1(osph)1(orylates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.38400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.88400269 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.16100311 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.66100311 74.12200165 Tm [(inac)-1(t)1(ivat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.16200256 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.66200256 74.12200165 Tm [(BCKD.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.06399536 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.56399536 74.12200165 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.5019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.0019989 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.92399597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.42399597 74.12200165 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(aria)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.84600067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.34600067 89.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.68800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.18800354 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.12799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.62799835 89.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.78799438 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.28799438 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.63499451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.13499451 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.64199829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.14199829 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.83200073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.33200073 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.61000061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 105.3219986 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.63800049 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.92500305 16.35000038 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.89900017 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.92500305 16.35000038 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(BCKDK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.9489994 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 155.92500305 31.95000076 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Syn)-1(t)1(hesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.35400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.85400009 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.06800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.56800079 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3500061 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56100464 11.72200012 Tm [(Internal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.40600586 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.44700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.94700623 11.72200012 Tm [(BCK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(D.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.02200031 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.59999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 0.75 m 155.55000305 109.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 110.69999695 m 155.55000305 126.29999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 127.04999542 m 155.55000305 142.6499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 143.3999939 m 155.55000305 174.59999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.59999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97499084 m 423.17498779 174.97499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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