%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 124 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.14099884 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 137.81700134 23.67700005 Tm 0 Tr [(CUEDC)-1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.71800232 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 327.1579895 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CUEDC)-1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 124.09300232 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.59300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.84300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CU)1(E)-1(DC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.5759964 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.94999695 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.6000061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.97399902 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.53300476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.90699768 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.70300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C10orf66;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.09700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.47100067 12.82499981 Tm [(bA18I1)1(4.)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.96800232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CUEDC)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 155.17500305 78.75 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CUE)1(DC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.84199905 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.34199905 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.90299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.40299988 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.27200317 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.21299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.71299744 11.72200012 Tm [(ubiquitin-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.28700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.78700256 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.06399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.56399536 11.72200012 Tm [(pro)1(teasome-media)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 27.3220005 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.14099884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.64099884 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.48300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.98300171 27.3220005 Tm [(pro)1(gesterone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.18899536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.68899536 27.3220005 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.11099243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.61099243 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.88800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.38800049 27.3220005 Tm [(estro)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.58099365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.08099365 27.3220005 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.98500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.48500061 42.92200089 Tm [(\(ER\)-)1(alph)1(a.CU)1(EDC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.85600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.35600281 42.92200089 Tm [(reduc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.57800293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.07800293 42.92200089 Tm [(PRB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.10699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.60699463 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.91400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.41400146 42.92200089 Tm [(conten)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.55299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 58.52199936 Tm [(pro)1(moted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.05400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.55400085 58.52199936 Tm [(pro)1(gesterone-induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.272995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.772995 58.52199936 Tm [(PRB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.30200195 58.52199936 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.08000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.58000183 58.52199936 Tm [(vi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.47599983 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.97599983 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(a)1(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.31800079 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.81800079 74.12200165 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.44599915 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CUE)1(DC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.84199905 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(CUE)1(DC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.18800354 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CUE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.68799973 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.18799973 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.01499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.51499939 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.26200104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.76200104 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.04000092 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C10)-1(or)1(f66)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.57699966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.07699966 11.72200012 Tm [(bA)1(1)-1(8I1)-1(4.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.35900116 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(46)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.4070015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 0.75 m 154.80000305 78.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 79.5 m 154.80000305 95.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 95.84999847 m 154.80000305 111.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 112.19999695 m 154.80000305 127.79999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 128.54998779 m 154.80000305 144.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 144.8999939 m 154.80000305 160.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 161.25 m 154.80000305 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.2250061 m 423.17498779 177.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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