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395.44699097 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CT)-1(TN)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 109.23500061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 111.60900116 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr4)1(66\))] TJ ET EMC /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 187.84199524 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 240.34199524 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 250.84199524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 15 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 16 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CTTN)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 106.34300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 108.71700287 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr4)1(66\))] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 184.94999695 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 187.32400513 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 212.97399902 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 215.3480072 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 258.90701294 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 261.28100586 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 299.07699585 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Am)1(p)-1(laxi)-1(n;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 105.70200348 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 108.0759964 12.82499981 Tm [(CT)-1(TN)1(;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 133.49499512 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 135.8690033 12.82499981 Tm [(EMS)-1(1;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 162.92900085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 165.30299377 12.82499981 Tm [(SRC)-1(8)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 186.74899292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CT)-1(TN)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 85.61000061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 87.98400116 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr4)1(66\))] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 164.21699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 92 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 93 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 95 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 97 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 138.67500305 172.3500061 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cort)1(actin)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 39.31299973 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 43.81299973 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 50.37400055 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 54.87400055 11.72200012 Tm [(overexpressed)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 117.01699829 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 121.51699829 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 129.45799255 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 133.95799255 11.72200012 Tm [(breast)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 160.74299622 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 165.24299622 11.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 193.33299255 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 197.83299255 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 214.11000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 218.61000061 11.72200012 Tm [(squa)1(mous)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 262.92001343 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 267.42001343 11.72200012 Tm [(c)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ell)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 9.89599991 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 14.39599991 27.3220005 Tm [(carc)-1(inoma)1(s)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 63.06999969 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 67.56999969 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 76.41200256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 80.91200256 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 94.91300201 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 99.41300201 27.3220005 Tm [(head)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 120.79199982 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 125.29199982 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 141.56900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 146.06900024 27.3220005 Tm [(ne)-1(ck.)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 168.30099487 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 172.80099487 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 188.60800171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 193.10800171 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 230.61500549 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 235.11500549 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 266.42199707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 270.92199707 27.3220005 Tm [(i)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(localized)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 46.34899902 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 50.84899902 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 58.79000092 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 63.29000092 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 77.29100037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 81.79100037 42.92200089 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 125.85900116 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 130.35899353 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 146.63600159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 151.13600159 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 159.07699585 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 163.57699585 42.92200089 Tm [(areas)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 186.23500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 190.73500061 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 199.57699585 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 204.07699585 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 218.07800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 222.57800293 42.92200089 Tm [(ce)-1(ll-sub)1(stra)1(t)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(um)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 13.97900009 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 18.47900009 58.52199936 Tm [(contacts.)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 56.7859993 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 61.2859993 58.52199936 Tm [(This)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 78.54799652 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 83.04799652 58.52199936 Tm [(gene)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 104.56400299 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 109.06400299 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 123.7460022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 128.2460022 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 144.42700195 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 148.92700195 58.52199936 Tm [(roles:)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 171.91900635 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 176.41900635 58.52199936 Tm [(\(1\))] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 187.70899963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 192.20899963 58.52199936 Tm [(regulat)1(i)-1(ng)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 236.4750061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 240.9750061 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 254.97599792 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 259.47601318 58.52199936 Tm [(inte)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ractio)1(n)-1(s)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 34.10599899 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 38.60599899 74.12200165 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 75.6780014 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 80.1780014 74.12200165 Tm [(components)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 134.03300476 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 138.53300476 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 147.375 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 151.875 74.12200165 Tm [(ad)1(here)-1(ns-)1(type)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 214.37399292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 218.87399292 74.12200165 Tm [(jun)-1(ctio)1(n)-1(s)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 258.06399536 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 262.56399536 74.12200165 Tm [(an)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(d)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(\(2\))] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 21.54700089 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 26.04700089 89.72200012 Tm [(org)1(anizing)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 72.00099945 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 76.50099945 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 90.5019989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 95.0019989 89.72200012 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 149.647995 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 154.147995 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 170.42500305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 174.92500305 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 189.33500671 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 193.83500671 89.72200012 Tm [(ad)1(hesion)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 233.04299927 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 237.54299927 89.72200012 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 17.50799942 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 22.00799942 105.3219986 Tm [(epith)1(e)-1(lia)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 59.02299881 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 63.52299881 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 79.80000305 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 84.30000305 105.3219986 Tm [(carci)-1(noma)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 128.80799866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 133.30799866 105.3219986 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 154.05000305 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 158.55000305 105.3219986 Tm [(During)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 188.08599854 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 192.58599854 105.3219986 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 236.74699402 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 241.24699402 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 255.2480011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 259.74798584 105.3219986 Tm [(en)-1(c)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(od)1(e)-1(d)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 22.34199905 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 26.84199905 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 58.14899826 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 62.64899826 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 69.20999908 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 73.70999908 120.92199707 Tm [(degra)1(ded)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 115.36100006 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 119.86100006 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 127.80200195 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 132.30200195 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 137.2769928 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 141.7769928 120.92199707 Tm [(caspa)1(se)-1(-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 226.34500122 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 230.84500122 120.92199707 Tm [(manne)-1(r)1(.)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 266.0539856 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 270.5539856 120.92199707 Tm [(T)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(he)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 10.64799976 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 15.14799976 136.52200317 Tm [(ab)1(e)-1(rr)1(ant)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 51.72399902 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 56.22399902 136.52200317 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 100.45500183 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 104.95500183 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 113.79699707 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 118.29699707 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 133.75300598 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 138.25300598 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 159.76899719 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 164.26899719 136.52200317 Tm [(contribut)1(e)-1(s)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 213.15400696 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 217.65400696 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 226.72900391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 231.22900391 136.52200317 Tm [(tumor)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 257.71899414 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 262.21899414 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 276.6289978 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(invasion)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 35.4679985 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 39.9679985 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 56.24499893 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 60.74499893 152.12199402 Tm [(metast)1(asis.)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 107.99900055 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 112.49900055 152.12199402 Tm [(Two)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 130.48599243 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 134.98599243 152.12199402 Tm [(splice)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 159.30999756 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 163.80999756 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 197.38000488 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 201.88000488 152.12199402 Tm [(th)1(at)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 219.102005 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 223.602005 152.12199402 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 255.352005 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 259.85198975 152.12199402 Tm [(dif)1(f)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ere)-1(nt)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 22.54800034 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 27.04800034 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 64.20800018 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 68.70800018 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 89.05500031 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 93.55500031 167.72200012 Tm [(been)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 115.06199646 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 119.56199646 167.72200012 Tm [(identified)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 160.49299622 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 164.99299622 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 177.27099609 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 181.77099609 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 197.227005 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 201.727005 167.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 225.40899658 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 0.75 m 138.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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