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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.41400146 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.08999634 23.67700005 Tm 0 Tr [(BCAS)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.44599915 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 319.88598633 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(BCAS2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.28199768 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 158.78199768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.03199768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BCA)1(S)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.26499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.63899994 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.28900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.66299438 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.22200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.59599304 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.39199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DAM1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.64399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.01799774 12.82499981 Tm [(SPF)-1(2)1(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.54399872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.91799927 12.82499981 Tm [(Sn)-1(t30)1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.74099731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BCAS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.53199768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 169.42500305 0.75 l 169.42500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 170.42500305 -0.25 l 170.42500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 170.17500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 170.17500305 172.3500061 l h f* Q q 1 0 0 1 169.80000305 0 cm -0.625 -0.25 m 253.625 -0.25 l 253.625 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BCAS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.47200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [(\(br)1(e)-1(as)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.76300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.26300049 11.72200012 Tm [(carci)-1(noma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.77100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.27100372 11.72200012 Tm [(amp)1(l)-1(if)1(ie)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.09500122 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.94200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.44200134 11.72200012 Tm [(2\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.89199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.39199829 11.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.64900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(designat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.91799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.41799927 27.3220005 Tm [(DA)1(M1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.67700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.17700195 27.3220005 Tm [(\(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.18800354 27.3220005 Tm [(amp)1(l)-1(if)1(ie)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.51199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.01199341 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.95300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.45300293 27.3220005 Tm [(mammar)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.9019928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.4019928 27.3220005 Tm [(carci)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(oma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.12899971 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.62899971 42.92200089 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.90699959 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.4070015 42.92200089 Tm [(pro)1(tein)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.71900177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.21900177 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.3769989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.8769989 42.92200089 Tm [(splice)-1(o)1(some-asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.3710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.8710022 42.92200089 Tm [(SPF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.35299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.85299683 42.92200089 Tm [(27)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.57499695 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.07499695 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.63600159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 58.52199936 Tm [(ubiquito)1(usly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.80699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.30699921 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.46099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.96099854 58.52199936 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.47900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.97900391 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.28599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.78599548 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.00799561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.50799561 58.52199936 Tm [(wa)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.75500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.25500488 58.52199936 Tm [(ori)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ginally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.22599983 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.72600174 74.12200165 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.65699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.15699768 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.29799652 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.79799652 74.12200165 Tm [(being)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34999847 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.84999847 74.12200165 Tm [(overexpressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.99299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.49299622 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.43400574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.93400574 74.12200165 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.897995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.397995 74.12200165 Tm [(br)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(east)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.60000038 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.10000038 89.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.18999863 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.68999863 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.09999847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.59999847 89.72200012 Tm [(line)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.375 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.875 89.72200012 Tm [(BCAS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.34700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.84700012 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.40800476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.90800476 89.72200012 Tm [(now)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.28199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.78199768 89.72200012 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.60099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.10099792 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.17599487 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.67599487 89.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.52999878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.02999878 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.00500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.50500488 89.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(omp)1(one)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.17599869 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.67599869 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.51800156 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.01800156 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.01899719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.51899719 105.3219986 Tm [(splice)-1(o)1(some,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.15800476 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.65800476 105.3219986 Tm [(pa)1(rticipat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.24699402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.74699402 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.68800354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.18800354 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.18899536 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.68899536 105.3219986 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mova)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.24900055 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.74900055 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.5909996 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.0909996 120.92199707 Tm [(intro)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.25499725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.75499725 120.92199707 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.46600342 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.96600342 120.92199707 Tm [(mRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.92399597 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42399597 120.92199707 Tm [(precu)-1(r)1(sors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.86700439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.36700439 120.92199707 Tm [(BCAS2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.83900452 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.33900452 120.92199707 Tm [(speci)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(fically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.55699921 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.05699921 136.52200317 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90100098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.40100098 136.52200317 Tm [(\(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.34799957 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.84799957 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.82299805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.32299805 136.52200317 Tm [(ligand)1(-indepen)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.00799561 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.50799561 136.52200317 Tm [(manne)-1(r)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.55599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.05599976 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.45199585 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(TR)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 11.03499985 152.12199402 Tm [<002D>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 16.31699944 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.81699944 152.12199402 Tm [(\(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.79100037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.29100037 152.12199402 Tm [(ho)1(rmone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.79799652 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.29799652 152.12199402 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.72000122 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.22000122 152.12199402 Tm [(beta)1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.57400513 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.07400513 152.12199402 Tm [(ER)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.897995 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.397995 152.12199402 Tm [(\(estro)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.59700012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.09700012 152.12199402 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ce)-1(pt)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.87899971 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.37900162 167.72200012 Tm [(alph)1(a\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.18500137 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.68499756 167.72200012 Tm [(ER)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 76.50900269 167.72200012 Tm [<002D>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 81.79100037 167.72200012 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.95800018 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.45800018 167.72200012 Tm [(PR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.83999634 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.33999634 167.72200012 Tm [(\(pr)1(ogesterone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.55099487 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.05099487 167.72200012 Tm [(rec)-1(ept)1(or\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.64500427 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.14500427 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.42199707 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.92199707 167.72200012 Tm [(P)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 169.80000305 0.75 m 169.80000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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