%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 146 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 10.37800026 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 60.05400085 23.67700005 Tm 0 Tr [(BCAR1\()1(Phosp)1(ho)1(-)-1(Ty)1(r)-1(41)1(0\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.48098755 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 294.48098755 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 404.92098999 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(BCAR1\(P)1(h)-1(osp)-1(ho-)-1(Ty)1(r410\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.26600647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 196.51600647 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 249.01600647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.76599121 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(BCA)1(R1\(Pho)-1(sph)-1(o-Tyr41)1(0\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.375 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.74899292 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.39900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.772995 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.33200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.70599365 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.50201416 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CAS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.30799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.68199921 12.82499981 Tm [(CAS1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.31199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.68599701 12.82499981 Tm [(CASS)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.13999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.51400757 12.82499981 Tm [(CRKA)1(S)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.97799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.352005 12.82499981 Tm [(P1)1(30Cas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.477005 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(BCAR1\(P)1(h)-1(osp)-1(ho-)-1(Ty)1(r410\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.64100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 155.92500305 109.94999695 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BCAR1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.31999969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.81999969 11.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.97800064 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.47800064 11.72200012 Tm [(CAS,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.19200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.69200134 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.25299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.75299835 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.27400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.77400208 11.72200012 Tm [(Src)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.91799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.41799927 11.72200012 Tm [(\(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.65600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.15600586 11.72200012 Tm [(19)-1(00)-1(90)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.82899475 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.32899475 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.41099548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.91099548 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.99899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.49899292 11.72200012 Tm [(su)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(bst)1(rat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.13800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.63800049 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.00700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.50700378 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.44799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.94799805 27.3220005 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.91200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.41200256 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.17399597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.67399597 27.3220005 Tm [(eve)-1(nt)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.84199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.34199524 27.3220005 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.19200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.69200134 27.3220005 Tm [(migr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.15699959 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.65699959 42.92200089 Tm [(survival,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.18500137 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.68499756 42.92200089 Tm [(tr)1(ansfor)1(m)-1(a)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.02900696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.52900696 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.80599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.30599976 42.92200089 Tm [(invasion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.94099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.44099426 42.92200089 Tm [(Do)1(c)-1(kin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.1289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.6289978 42.92200089 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.39999962 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.99700165 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.49700165 58.52199936 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.54399872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.04399872 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.01899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.51899719 58.52199936 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84400177 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.34400177 58.52199936 Tm [(coord)1(i)-1(na)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.46000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.96000671 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.61999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.11999512 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.397995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.897995 58.52199936 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.38600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ki)-1(na)1(se)-1(-)1(based)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.73300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.23300171 74.12200165 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.16400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66400146 74.12200165 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.79299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.29299927 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.36799622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.86799622 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.27799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.77799988 74.12200165 Tm [(ad)1(hesion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.65299988 74.12200165 Tm [(Implicate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.69799995 89.72200012 Tm [(induc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.47000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.97000122 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.81199646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.31199646 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.22200012 89.72200012 Tm [(migra)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.3999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.8999939 89.72200012 Tm [(Overexpression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.45500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.95500183 89.72200012 Tm [(confers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.56500244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(antiest)1(rogen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.96099854 105.3219986 Tm [(resista)1(n)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.72399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.22399902 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.49199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 105.3219986 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.7769928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.2769928 105.3219986 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.36700439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.86700439 105.3219986 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.60899353 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.92500305 16.35000038 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.92500305 16.35000038 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BCAR1\(Phos)1(pho-)1(Ty)-1(r410)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.19799805 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 155.17500305 0.75 l 155.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 156.17500305 -0.25 l 156.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 155.92500305 31.95000076 l h f* Q q 1 0 0 1 155.55000305 0 cm -0.625 -0.25 m 267.875 -0.25 l 267.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(tyro)1(sin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(41)-1(0\(G-V-)1(Y\(p\)-)1(A-)1(V)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.41500092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.91500092 27.3220005 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.1969986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.69700623 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.40800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.90800476 27.3220005 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.36799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.86799622 27.3220005 Tm [(p13)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.44999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.94999695 27.3220005 Tm [(Cas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.11099243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.61099243 27.3220005 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.77799988 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 0.75 m 155.55000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 110.69999695 m 155.55000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 127.04999542 m 155.55000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.55000305 143.3999939 m 155.55000305 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.59999084 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97499084 m 423.17498779 174.97499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>