%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 159 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 103.72299957 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 153.39900208 23.67700005 Tm 0 Tr [(CTSL)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 201.13699341 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 311.57699585 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CT)-1(SL)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 98.70400238 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 151.20399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.95399475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CTS)-1(L)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.68800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.06199646 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.71200562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.08599854 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.01899719 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.81500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MEP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.33799744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.71199799 12.82499981 Tm [(CATL)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.72699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.10099792 12.82499981 Tm [(CT)-1(SL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.3769989 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CT)-1(SL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.95400238 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 155.17500305 141.1499939 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(lysosoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.37800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.87800598 11.72200012 Tm [(cy)-1(st)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(pro)1(tein)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.15999985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.65999985 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.88200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.38200378 27.3220005 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.42900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.92900085 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.90399933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.40399933 27.3220005 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.37399292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.87399292 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.53399658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.03399658 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.9750061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.4750061 27.3220005 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.94200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.44200134 27.3220005 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 42.92200089 Tm [(cata)1(bolism.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.2820015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.78199768 42.92200089 Tm [(Its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.9469986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.4469986 42.92200089 Tm [(subst)1(rat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.46299744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.96299744 42.92200089 Tm [(inc)-1(lude)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.22099304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.72099304 42.92200089 Tm [(collagen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.13000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.63000488 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.90699768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.40699768 42.92200089 Tm [(elastin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.51000977 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 58.52199936 Tm [(well)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.64299965 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.14300156 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.2840004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.7840004 58.52199936 Tm [(alph)1(a-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.58899689 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.08899689 58.52199936 Tm [(pro)1(tease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.70200348 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.20199585 58.52199936 Tm [(inhibito)1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.8999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.3999939 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.875 58.52199936 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.84500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.34500122 58.52199936 Tm [(controlling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.125 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ele)-1(ment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.04600143 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.54600143 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.38800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.88800049 74.12200165 Tm [(ne)-1(ut)1(roph)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.17700195 74.12200165 Tm [(elasta)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.41900635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.91900635 74.12200165 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.55700684 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05700684 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.86399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.36399841 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.8710022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.3710022 74.12200165 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.22900009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.72900009 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.23600006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.73600006 89.72200012 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.80599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.30599976 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.24700165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.74700165 89.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.65600586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.15600586 89.72200012 Tm [(pa)1(tho)1(l)-1(o)1(gic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.2769928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.7769928 89.72200012 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.07400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.84999847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.34999847 105.3219986 Tm [(myofibr)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.75800323 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.25800323 105.3219986 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.30899811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.80899811 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.75 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.25 105.3219986 Tm [(myopa)1(thies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.45300293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.95300293 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.22999573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.72999573 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.67100525 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.17100525 105.3219986 Tm [(myoc)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(dia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.52099991 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.02099991 120.92199707 Tm [(ische)-1(mia)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.7120018 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.21199799 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.48899841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.98899841 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.93000031 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.43000031 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.43099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.93099976 120.92199707 Tm [(renal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.38900757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.88900757 120.92199707 Tm [(tub)1(u)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.88800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.38800049 120.92199707 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.38499451 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.88499451 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.96000671 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.46000671 120.92199707 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nuria.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.06399918 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.625 -0.25 l 268.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CTSL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.99300003 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 0.75 m 154.80000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 141.8999939 m 154.80000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 158.25 m 154.80000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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