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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 102.35800171 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 152.03399658 23.67700005 Tm 0 Tr [(CTSK)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 202.50100708 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 312.94100952 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84.18499756 12.82499981 Tm [(CT)-1(SK)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 107.80500031 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.30499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.55499268 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CTS)-1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.10199738 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.7519989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.12600708 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.68499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.05900574 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.85499573 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(CT)-1(SO;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.30200195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.6760025 12.82499981 Tm [(PK)1(ND;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.60299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.97699738 12.82499981 Tm [(PYCD;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.38600159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.76000214 12.82499981 Tm [(CT)-1(S02;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.75300598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.1269989 12.82499981 Tm [(CT)-1(SO1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.75 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.12399292 12.82499981 Tm [(CT)-1(SO2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.93800354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(CT)-1(SK)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.99499893 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019001A001B000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001C0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D001E001F0020>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0021>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001B0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACH 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 423.39001465 cm /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 464.58999634 cm q /GS2 gs 1 g 0.375 0.75 m 153.67500305 0.75 l 153.67500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 154.67500305 -0.25 l 154.67500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.42500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 154.42500305 141.1499939 l h f* Q q 1 0 0 1 154.05000305 0 cm -0.625 -0.25 m 269.375 -0.25 l 269.375 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(lysosoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.37800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.87800598 11.72200012 Tm [(cy)-1(st)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(pro)1(tein)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.15999985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.65999985 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.02899933 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.52899933 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.47000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.97000122 27.3220005 Tm [(bo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.09199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.59199524 27.3220005 Tm [(remodeling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.2460022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.7460022 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.022995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.522995 27.3220005 Tm [(resorp)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.42900085 42.92200089 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.90200043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.40200043 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.49900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.99900055 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.55999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.05999756 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.03500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.53500366 42.92200089 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.79899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.29899597 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.14100647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.64100647 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.64199829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.14199829 42.92200089 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.4960022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.9960022 42.92200089 Tm [(C1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.29400635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.79400635 42.92200089 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 58.52199936 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.86999893 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.36999893 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.93099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.43099976 58.52199936 Tm [(predo)1(min)-1(a)1(n)-1(t)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.60699463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.10699463 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.26100159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.76100159 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.70199585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.20199585 58.52199936 Tm [(ost)1(e)-1(o)1(c)-1(last)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.00500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.50500488 58.52199936 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ow)1(e)-1(ver,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.36800003 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.86800003 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.86899948 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.36899948 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.87599945 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.37599945 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.68299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.18299866 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.7440033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.2440033 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.50100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.00100708 74.12200165 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.15499878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.65499878 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.59599304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.09599304 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.07099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.57099915 74.12200165 Tm [(signif)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ic)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.78199959 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.28199959 89.72200012 Tm [(fra)1(c)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.34199905 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.84199905 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.68399811 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.18399811 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.22499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.72499847 89.72200012 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.50999451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.00999451 89.72200012 Tm [(canc)-1(ers,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.43200684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.93200684 89.72200012 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.22900391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.72900391 89.72200012 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.477005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.977005 89.72200012 Tm [(coul)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.91000366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.41000366 89.72200012 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ntrib)1(u)-1(t)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.48400116 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.98400116 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.05899811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.55899811 105.3219986 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.0490036 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.5490036 105.3219986 Tm [(invasivene)-1(ss.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.73100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.23100281 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.08000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.58000183 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.52099609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.02099609 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.477005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.977005 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.49299622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.99299622 105.3219986 Tm [(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.60700035 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.10700035 120.92199707 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.4129982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.9129982 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.75499725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.25499725 120.92199707 Tm [(pycn)-1(o)1(dysost)1(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.08999634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.11099243 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.61099243 120.92199707 Tm [(auto)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.89700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.39700317 120.92199707 Tm [(rec)-1(essive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.11700439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(disease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.67099953 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.17100143 136.52200317 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.70400238 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.20400238 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.71600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.21600342 136.52200317 Tm [(ost)1(e)-1(o)1(sc)-1(lerosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.35099792 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.85099792 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.12800598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.62800598 136.52200317 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.84700012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.34700012 136.52200317 Tm [(st)1(ature.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.44900513 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 153.67500305 0.75 l 153.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.67500305 -0.25 l 154.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.42500305 16.35000038 l h f* Q q 1 0 0 1 154.05000305 0 cm -0.625 -0.25 m 269.375 -0.25 l 269.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.05000305 0.75 m 154.05000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.05000305 141.8999939 m 154.05000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.875 m 423.17498779 157.875 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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