%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 141 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 103.32499695 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 153.00100708 23.67700005 Tm 0 Tr [(CTSF)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 201.53399658 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 311.97399902 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CT)-1(SF)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.11399841 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 151.61399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.11399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CTS)-1(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.09799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.47200012 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.12199402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.4960022 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.05499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.42900085 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.2250061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cathepsi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.27700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.65100098 12.82499981 Tm [(F;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.28500366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.65899658 12.82499981 Tm [(CATS)-1(F;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.90800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.28199768 12.82499981 Tm [(CL)-1(N)1(13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.71600342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CT)-1(SF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.36399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 160.42500305 0.75 l 160.42500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 161.42500305 -0.25 l 161.42500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.17500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 161.17500305 172.3500061 l h f* Q q 1 0 0 1 160.80000305 0 cm -0.625 -0.25 m 262.625 -0.25 l 262.625 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cat)1(hepsins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.01699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.51699829 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.03500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.53500366 11.72200012 Tm [(pa)1(pain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.92099762 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.42099762 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.50300598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.00300598 11.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.95300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.45300293 11.72200012 Tm [(pro)1(tein)-1(a)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.17300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.67300415 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.89500427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.39500427 11.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(eprese)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.56900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.06900024 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.04399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.54399872 27.3220005 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.51399994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.01399994 27.3220005 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.70300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.20300293 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.04499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.54499817 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.54600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.04600525 27.3220005 Tm [(lysosoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.78300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.28300476 27.3220005 Tm [(pro)1(teolyt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.90799999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.40799999 42.92200089 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.56299973 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.06299973 42.92200089 Tm [(Cat)1(hepsins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.08000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.58000183 42.92200089 Tm [(gene)-1(r)1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.05999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.55999756 42.92200089 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.60899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.10899353 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.08399963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.58399963 42.92200089 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.81700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.31700134 42.92200089 Tm [(seque)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ce)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.78600025 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.2859993 58.52199936 Tm [(fo)1(l)-1(lo)1(wed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.60900116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.10900116 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.6210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.1210022 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.09600067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.59600067 58.52199936 Tm [(pro)1(peptid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.71600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.21600342 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.49299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.99299622 58.52199936 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.53999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.03999329 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.01499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.51499939 58.52199936 Tm [(cata)1(l)-1(yt)1(i)-1(cally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.27900696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.77900696 58.52199936 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.57900047 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.07900047 74.12200165 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.92900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.42900085 74.12200165 Tm [(region.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.55799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.05799866 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.86499786 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.36499786 74.12200165 Tm [(very)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.39599609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.89599609 74.12200165 Tm [(long)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.31500244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.81500244 74.12200165 Tm [(\(25)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.65400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.15400696 74.12200165 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.22399902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.72399902 74.12200165 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.36399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.86399841 74.12200165 Tm [(resi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(dues\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.58099937 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.08099937 89.72200012 Tm [(pro)1(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.94999695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.44999695 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.29199982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.79199982 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.79299927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.29299927 89.72200012 Tm [(cath)1(e)-1(ps)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.63699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.13699341 89.72200012 Tm [(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.91799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.41799927 89.72200012 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.52900696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.02900696 89.72200012 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.2440033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.7440033 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.71899414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.55400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.05400085 105.3219986 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.8809967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.3809967 105.3219986 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5759964 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.0759964 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.15100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.65100098 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.6519928 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.1519928 105.3219986 Tm [(pro)1(-segment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.41999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.91999817 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.76199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.26199341 105.3219986 Tm [(cath)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(psin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.85499954 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.35499954 120.92199707 Tm [(L-like)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.66400146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.16400146 120.92199707 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.8769989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.3769989 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.35199738 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.85199738 120.92199707 Tm [(50)-1(-)1(re)-1(sid)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.81399536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.31399536 120.92199707 Tm [(flexible)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.14199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.64199829 120.92199707 Tm [(link)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.42100525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.92100525 120.92199707 Tm [(pept)1(ide,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.30099487 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.29800034 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.79800034 136.52200317 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.64800262 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.14800262 136.52200317 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97499847 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.47499847 136.52200317 Tm [(predicted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.64700317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.14700317 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.22200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.72200012 136.52200317 Tm [(ad)1(opt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.27600098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.77600098 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.75100708 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.25100708 136.52200317 Tm [(cy)-1(st)1(ati)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n-like)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.23600006 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.73600006 152.12199402 Tm [(fo)1(l)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.89599991 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.39599991 152.12199402 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.20300293 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.70300293 152.12199402 Tm [(cath)1(e)-1(ps)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.04699707 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.54699707 152.12199402 Tm [(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.32800293 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.82800293 152.12199402 Tm [(pro)1(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.69700623 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.19700623 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.75799561 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.25799561 152.12199402 Tm [(uni)-1(q)1(ue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.15400696 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.65400696 152.12199402 Tm [(wit)1(hin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.99000549 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 167.72200012 Tm [(pa)1(pain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.88700104 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.38700104 167.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.46900177 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.96900177 167.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91899872 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41899872 167.72200012 Tm [(pro)1(teases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.19799805 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.69799805 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.63900757 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.13900757 167.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.36099243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.86099243 167.72200012 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.60899353 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.10899353 167.72200012 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.32400513 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.80000305 0.75 m 160.80000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>