%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 92.96399689 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 142.63999939 23.67700005 Tm 0 Tr [(AURKC)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 211.89500427 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 322.33499146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(AU)1(RKC)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.81700134 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.31700134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.06700134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(URK)1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.3010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.67500305 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.32499695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.69900513 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.25799561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.63200378 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.42799377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AIE2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.97899628 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.35299683 12.82499981 Tm [(AIK)1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.66000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.03399658 12.82499981 Tm [(ARK)1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.39700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.77099609 12.82499981 Tm [(AurC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.43200684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.80599976 12.82499981 Tm [(SPGF5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.63499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.00900269 12.82499981 Tm [(ST)-1(K)1(13;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.23199463 12.82499981 Tm [(aurora-C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.47900391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AU)1(RKC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.56700134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 161.5249939 141.1499939 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2749939 -0.25 l 262.2749939 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(Auro)1(ra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.7250061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.2250061 11.72200012 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.76699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.69599915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.19599915 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.50299835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.00299835 27.3220005 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.42300415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.92300415 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.72999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.22999573 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.73699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.23699951 27.3220005 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.58200073 42.92200089 Tm [(chromos)1(omal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.63999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.13999939 42.92200089 Tm [(pa)1(sse)-1(ng)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.14700317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.64700317 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.95399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.45399475 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.67599487 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.17599487 42.92200089 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.05299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.55299377 42.92200089 Tm [(comp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(lexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.33499908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.83499908 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.23099899 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.73099899 58.52199936 Tm [(Auro)1(ra-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.71900177 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.21900177 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.4960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9960022 58.52199936 Tm [(inn)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.02600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.52600098 58.52199936 Tm [(ce)-1(ntr)1(ome)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.28500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.78500366 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.25799561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.75799561 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.03500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.55199814 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.05199814 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.02700043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.52700043 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.18699646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.68699646 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.62799835 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.12799835 74.12200165 Tm [(org)1(anizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.08200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.58200073 74.12200165 Tm [(mic)-1(r)1(otubules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.94200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.44200134 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.38299561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.88299561 74.12200165 Tm [(relatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.81100464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.31100464 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 89.72200012 Tm [(ce)-1(ntr)1(osome/spindle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.28399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.78399658 89.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.5249939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.0249939 89.72200012 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.46200562 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.96200562 89.72200012 Tm [(mito)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.75799561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.25799561 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.52000427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.02000427 89.72200012 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.16699982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.66699982 105.3219986 Tm [(overexpressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.80999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30999756 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.25099945 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75099945 105.3219986 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.66000366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.16000366 105.3219986 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.25 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.75 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.16000366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.66000366 105.3219986 Tm [(line)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.43499756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.93499756 105.3219986 Tm [(sugg)1(e)-1(st)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.27799988 120.92199707 Tm [(involveme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.32900238 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.82900238 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.76999664 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.26999664 120.92199707 Tm [(oncogeni)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.08999634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.58999634 120.92199707 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.82299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.32299805 120.92199707 Tm [(tr)1(ansduc)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.79699707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.29699707 120.92199707 Tm [(Alt)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.5359993 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0359993 136.52200317 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.9509964 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.4509964 136.52200317 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.62000275 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.12000275 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.06099701 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.56099701 136.52200317 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.93299866 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.43299866 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.35499573 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.85499573 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.59100342 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2749939 -0.25 l 262.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2749939 -0.25 l 262.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AU)1(RKC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.6609993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.1499939 0.75 m 161.1499939 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.1499939 141.8999939 m 161.1499939 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.1499939 158.25 m 161.1499939 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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