%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.3809967 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.05700684 23.67700005 Tm 0 Tr [(CSPG5)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.47799683 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.91799927 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CS)-1(P)1(G5)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.54299927 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.04299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.54299927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CSPG5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.52700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.90100098 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.55099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.92500305 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.48399353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.85800171 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.65400696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NG)1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(P)1(G5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.79299927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700220027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 155.5249939 63.15000153 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(pro)1(teoglycan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.67799377 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.17799377 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.3999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.41199875 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.91199875 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.0530014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.5530014 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.52799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.02799988 27.3220005 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.03199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.53199768 27.3220005 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.44799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.94799805 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.2250061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.7250061 27.3220005 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.05099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.55099487 27.3220005 Tm [(fa)1(c)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(or.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.32499981 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.82499981 42.92200089 Tm [(Se)-1(v)1(e)-1(ra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.76300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.26300049 42.92200089 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.18499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.68499756 42.92200089 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.25500488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.75500488 42.92200089 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.09700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.59700012 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.53700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.03700256 42.92200089 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.19699097 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.34700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.84700012 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.35400009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.85400009 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.54399872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.04399872 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.3219986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.8219986 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.27799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77799988 58.52199936 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.46000671 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CSPG5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.69199944 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 155.5249939 31.95000076 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.35400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.85400009 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.06800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.56800079 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3500061 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56100464 11.72200012 Tm [(internal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.31300354 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.81300354 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.65499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.15499878 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.69599915 11.72200012 Tm [(CSP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(G5.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.13700008 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(chondro)1(itin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.92599869 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.42599869 11.72200012 Tm [(sulfat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.08699799 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.58699799 11.72200012 Tm [(pro)1(teoglycan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.62399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.12399292 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.4019928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.9019928 11.72200012 Tm [(\(ne)-1(uro)1(glyc)-1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.21400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.71400452 11.72200012 Tm [(C\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.74000549 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<001C>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NGC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.03000069 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q /GS2 gs 1 g 0.375 0.75 m 154.7749939 0.75 l 154.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.7749939 -0.25 l 155.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.5249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 155.5249939 16.35000038 l h f* Q q 1 0 0 1 155.1499939 0 cm -0.625 -0.25 m 268.2749939 -0.25 l 268.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O95)-1(19)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.85002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 0.75 m 155.1499939 63.15000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 63.90000153 m 155.1499939 79.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 80.25 m 155.1499939 95.84999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 96.59999847 m 155.1499939 127.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 128.55000305 m 155.1499939 144.15000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 144.90000916 m 155.1499939 160.50001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 155.1499939 161.25001526 m 155.1499939 176.85002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.85002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17500305 m 422.42498779 128.17500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.52500916 m 422.42498779 144.52500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.87501526 m 422.42498779 160.87501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.22502136 m 423.17498779 177.22502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>