%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 159 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.74299622 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 132.41900635 23.67700005 Tm 0 Tr [(CSNK2)1(A1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 222.11599731 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 332.55599976 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CS)-1(N)1(K2A)1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.125 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.625 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.375 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CSNK)1(2A1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.10800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.48200226 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.13200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.5059967 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.06500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.43899536 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.23500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CKII,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.96499634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.33899689 12.82499981 Tm [(CK2A)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.11199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(N)1(K2A)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.375 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 154.0249939 156.75 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Casein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.70800018 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.79600143 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.29599762 11.72200012 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.58699799 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.08699799 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.64800262 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.14800262 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.1230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.6230011 11.72200012 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.477005 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.78399658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.28399658 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.37199402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.87199402 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.09399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ph)1(osph)1(orylates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.38400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.88400269 27.3220005 Tm [(acidic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.43199921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.93199921 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.40499878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.90499878 27.3220005 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.67199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.17199707 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.31300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.81300354 27.3220005 Tm [(casei)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.18099976 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.98800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.48800659 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.57598877 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(exists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.74799919 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24799919 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.38899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.88899994 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.86399841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.36399841 42.92200089 Tm [(tetr)1(amer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.56400299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06400299 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.34100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.84100342 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.40200043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.90200043 42.92200089 Tm [(composed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.06900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.56900024 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.41099548 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.91099548 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.43200684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.93200684 42.92200089 Tm [(alph)1(a,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.73199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.23199463 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.75300598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.25300598 42.92200089 Tm [(alp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ha)1(-prime,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.69499969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.19499969 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.97200012 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.15299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65299988 58.52199936 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.83499908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.33499908 58.52199936 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.96699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.46699524 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.27400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.77400208 58.52199936 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.40800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.90800476 58.52199936 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.37399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.87399292 58.52199936 Tm [(con)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ta)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.2689991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.7689991 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.77000046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.27000046 74.12200165 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.50499725 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.00499725 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.47699738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.97699738 74.12200165 Tm [(wh)1(il)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.52099609 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.02099609 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.02200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.52200317 74.12200165 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.70399475 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.20399475 74.12200165 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.66999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.16999817 74.12200165 Tm [(undergo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.04000854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(auto)1(pho)1(spho)1(ry)-1(la)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.53600311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.03600311 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.84300232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.34300232 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.6499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.1499939 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.65699768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.15699768 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.66900635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.16900635 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.625 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.125 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.64100647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.14099121 89.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(eprese)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.73500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.23500061 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.23600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.73600006 105.3219986 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.37000275 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.87000275 105.3219986 Tm [(subunit.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.33599854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.83599854 105.3219986 Tm [(Wh)1(il)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.43200684 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.93200684 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.38800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.88800049 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.40400696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.90400696 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.46499634 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.96499634 105.3219986 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.65499878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.15499878 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.42300415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 120.92199707 Tm [(20)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.01699829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.51699829 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.49199677 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.99199677 120.92199707 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.1210022 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.6210022 120.92199707 Tm [(tr)1(ansc)-1(rib)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.05299377 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.55299377 120.92199707 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.11399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.61399841 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.17500305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.67500305 120.92199707 Tm [(fo)1(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 136.52200317 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.07099915 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.57099915 136.52200317 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.36599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.86599731 136.52200317 Tm [(11)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.58799744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.08799744 136.52200317 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.43800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.93800354 136.52200317 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.86000061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.36000061 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.92999268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.42999268 136.52200317 Tm [(en)-1(cod)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 152.12199402 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.43799973 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.93799973 152.12199402 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.87799835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.37799835 152.12199402 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.85099792 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.35099792 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.69799805 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.19799805 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.70500183 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.20500183 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.89500427 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.39500427 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.67300415 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.17300415 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.6289978 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1289978 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.81100464 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 0.75 m 153.6499939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 157.5 m 153.6499939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>