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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.62400055 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 133.30000305 23.67700005 Tm 0 Tr [(ATXN7)1(L3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 221.23599243 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 331.67599487 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(ATXN)1(7L)-1(3)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.22799683 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.72799683 12.82499981 Tm [(    )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 190.72799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(T)-1(XN)1(7L3)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 122.21099854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 124.58499908 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 150.23500061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 152.60899353 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 196.16799927 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 198.54200745 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 236.33799744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATXN)1(7L)-1(3)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 101.47799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110025000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <</MCID 63 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 177.5249939 -0.25 l 177.5249939 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 67 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 177.2749939 187.94999695 l h f* Q q 1 0 0 1 176.8999939 0 cm -0.625 -0.25 m 246.5249939 -0.25 l 246.5249939 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Comp)1(one)-1(nt)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 51.19599915 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 55.69599915 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 64.53800201 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 69.03800201 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 83.03900146 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 87.53900146 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 142.1230011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 146.6230011 11.72200012 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 191.11300659 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 195.61300659 11.72200012 Tm [(hist)1(one)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 227.44299316 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 231.94299316 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ce)-1(t)1(y)-1(lat)1(ion)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 42.12200165 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 46.62200165 27.3220005 Tm [(\(HAT\))] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 71.08599854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 75.58599854 27.3220005 Tm [(complex)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 112.06500244 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 116.56500244 27.3220005 Tm [(SAG)1(A,)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 143.28399658 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 147.78399658 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 152.75900269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 157.25900269 27.3220005 Tm [(multipro)1(tein)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 210.68800354 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 215.18800354 27.3220005 Tm [(com)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(plex)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 17.81100082 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 22.31100082 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 39.53300095 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 44.03300095 42.92200089 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 81.59300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 86.09300232 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 140.67700195 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 145.17700195 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 155.68899536 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 160.18899536 42.92200089 Tm [(remodeling)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 209.84300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 214.34300232 42.92200089 Tm [(chro)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mat)1(in)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 24.70199966 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 29.20199966 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 45.47900009 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 49.97900009 58.52199936 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 93.69599915 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 98.19599915 58.52199936 Tm [(hist)1(one)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 130.02600098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 134.52600098 58.52199936 Tm [(ace)-1(t)1(yl)-1(a)1(tion)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 181.62199402 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 186.12199402 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 202.39900208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 206.89900208 58.52199936 Tm [(deubiq)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(uitinatio)1(n)-1(.)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 43.39199829 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 47.89199829 74.12200165 Tm [(Wit)1(hin)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 76.28099823 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 80.78099823 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 94.78199768 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 99.28199768 74.12200165 Tm [(SAG)1(A)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 123.83399963 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 128.33399963 74.12200165 Tm [(complex,)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 166.97999573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 171.47999573 74.12200165 Tm [(pa)1(rticipat)1(e)-1(s)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 221.64399719 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 226.14399719 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 234.08500671 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 4.9749999 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 9.47500038 89.72200012 Tm [(subcomplex)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 61.41400146 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 65.91400146 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 83.13600159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 87.63600159 89.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 134.1210022 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 138.6210022 89.72200012 Tm [(deubiquitinat)1(e)-1(s)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 205.76499939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 210.26499939 89.72200012 Tm [(bo)1(th)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 230.6289978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(hist)1(one)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 35.99599838 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 40.49599838 105.3219986 Tm [(H2)-1(A)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 59.06700134 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 63.56700134 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 79.84400177 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 84.34400177 105.3219986 Tm [(H2)-1(B.)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 104.39600372 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 108.89600372 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 124.70300293 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 129.20300293 105.3219986 Tm [(SAG)1(A)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 153.75500488 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 158.25500488 105.3219986 Tm [(complex)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 194.73399353 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 199.23399353 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 205.79499817 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 210.29499817 105.3219986 Tm [(rec)-1(ruit)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 24.43799973 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 28.93799973 120.92199707 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 60.89500046 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 65.39499664 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 86.91100311 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 91.41100311 120.92199707 Tm [(pro)1(moters)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 136.53399658 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 141.03399658 120.92199707 Tm [(by)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 151.54600525 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 156.04600525 120.92199707 Tm [(activat)1(ors)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 197.65800476 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 202.15800476 120.92199707 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 221.92500305 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 226.42500305 120.92199707 Tm [(as)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 235.56599426 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(MYC,)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 22.41200066 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 26.91200066 136.52200317 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 53.20899963 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 57.70899963 136.52200317 Tm [(it)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 63.45700073 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 67.95700073 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 74.51799774 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 79.01799774 136.52200317 Tm [(required)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 115.55899811 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 120.05899811 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 132.33700562 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 136.83700562 136.52200317 Tm [(tr)1(ansc)-1(rip)1(tion.)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 193.58799744 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 198.08799744 136.52200317 Tm [(Required)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 237.06700134 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 12.27799988 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 16.77799988 152.12199402 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 48.29600143 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 52.79600143 152.12199402 Tm [(rec)-1(ept)1(or-)1(m)-1(edia)1(ted)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 133.9940033 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 138.4940033 152.12199402 Tm [(tr)1(ansactivat)1(ion.)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 204.08700562 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 208.58700562 152.12199402 Tm [(Wit)1(hin)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 236.97599792 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 14.0010004 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 18.50099945 167.72200012 Tm [(complex,)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 57.14699936 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 61.64699936 167.72200012 Tm [(it)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 67.39499664 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 71.89499664 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 78.45600128 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 82.95600128 167.72200012 Tm [(required)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 119.49700165 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 123.99700165 167.72200012 Tm [(to)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 133.07200623 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 137.57200623 167.72200012 Tm [(rec)-1(ruit)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 165.35899353 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 169.85899353 167.72200012 Tm [(USP22)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 197.83500671 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 202.33500671 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 218.61199951 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 223.11199951 167.72200012 Tm [(EN)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(Y2)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 10.70899963 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 15.20899963 183.32200623 Tm [(into)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 32.22499847 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 36.72499847 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 50.72600174 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 55.22600174 183.32200623 Tm [(SAG)1(A)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 79.77799988 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 84.27799988 183.32200623 Tm [(complex.)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 122.9240036 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 176.5249939 0.75 l 176.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 177.5249939 -0.25 l 177.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 237 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 238 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 177.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 177.2749939 16.35000038 l h f* Q q 1 0 0 1 176.8999939 0 cm -0.625 -0.25 m 246.5249939 -0.25 l 246.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 239 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 0.75 m 176.8999939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 176.8999939 188.69999695 m 176.8999939 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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