%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 134 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 9.72799969 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 59.40399933 23.67700005 Tm 0 Tr [(ATXN1)1(\(Pho)1(spho)1(-Ser)-1(77)1(6\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.13101196 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 295.13101196 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 405.5710144 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(ATXN)1(1\()-1(P)1(h)-1(osph)-1(o-S)-1(e)1(r776)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.27900696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 186.52900696 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 239.02900696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.27900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(T)-1(XN)1(1\(Phos)-1(pho)-1(-Ser7)1(76\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.88699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.26100159 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.91099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.28500366 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.84399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.21798706 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.01400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATX1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.77300262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.14700317 12.82499981 Tm [(SC)-1(A)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.77700043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.15100098 12.82499981 Tm [(D6S)-1(5)1(04E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.84899902 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATXN)1(1\()-1(P)1(h)-1(osph)-1(o-S)-1(e)1(r776)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.15400696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 144.2749939 0.75 l 144.2749939 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 145.2749939 -0.25 l 145.2749939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.0249939 0.75 m 422.375 0.75 l 422.375 125.55000305 l 145.0249939 125.55000305 l h f* Q q 1 0 0 1 144.6499939 0 cm -0.625 -0.25 m 278.7250061 -0.25 l 278.7250061 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(auto)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.59300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.09300232 11.72200012 Tm [(do)1(mi)-1(na)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.81900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.31900024 11.72200012 Tm [(ce)-1(rebellar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.53700256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.03700256 11.72200012 Tm [(at)1(axias)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.43600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.93600464 11.72200012 Tm [(\(AD)1(CA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.48899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.98899841 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.50700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.00700378 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.98199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.48199463 11.72200012 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(eterogene)-1(o)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.67300034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.17299652 27.3220005 Tm [(gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.38200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.88200378 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.72399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.22399902 27.3220005 Tm [(ne)-1(uro)1(degen)-1(erat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.94900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.44900513 27.3220005 Tm [(diso)1(rders)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.39100647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.89100647 27.3220005 Tm [(chara)1(c)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(erized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.22699928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.72699928 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.23899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.73899841 42.92200089 Tm [(pro)1(gressive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.50299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.00299835 42.92200089 Tm [(degene)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.80900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.30900574 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.15100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.65100098 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.6519928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.1519928 42.92200089 Tm [(ce)-1(rebellu)-1(m,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.10499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.60499573 42.92200089 Tm [(bra)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(st)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.10499954 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.60499954 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.88199997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.38199997 58.52199936 Tm [(spinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.60700226 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.10700226 58.52199936 Tm [(cord.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.70200348 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.20200348 58.52199936 Tm [(Clinic)-1(ally,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.16099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.66099548 58.52199936 Tm [(AD)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.20199585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.70199585 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.38400269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.88400269 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.39100647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.89100647 58.52199936 Tm [(divid)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.78201294 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.01600075 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 74.12200165 Tm [(th)1(ree)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.06000137 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.56000137 74.12200165 Tm [(gr)1(oups:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.10199738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.60199738 74.12200165 Tm [(AD)1(CA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.14299774 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.64299774 74.12200165 Tm [(types)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.77999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.27999878 74.12200165 Tm [(I-II)1(I.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.92199707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.42199707 74.12200165 Tm [(AD)1(CAI)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.60899353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.10899353 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.66999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.16999817 74.12200165 Tm [(gene)-1(t)1(ic)-1(a)1(l)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.4750061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.9750061 74.12200165 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(terog)1(e)-1(neous,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.73300171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.23300171 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.6289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.1289978 89.72200012 Tm [(five)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.47499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.97499847 89.72200012 Tm [(gene)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.7519989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.2519989 89.72200012 Tm [(loci,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.44299316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.94299316 89.72200012 Tm [(designat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.86099243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.36099243 89.72200012 Tm [(spinocere)-1(b)1(e)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(lar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.80599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.30599976 105.3219986 Tm [(at)1(axia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.53900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.03900146 105.3219986 Tm [(\(SCA\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.59799957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.09799957 105.3219986 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.54199982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.04199982 105.3219986 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.48600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.98600006 105.3219986 Tm [(3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.43000031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.93000031 105.3219986 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.20800018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.70800018 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.98500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.48500061 105.3219986 Tm [(6,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.92900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.42900085 105.3219986 Tm [(being)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.98100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.48100281 105.3219986 Tm [(assig)1(ne)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.34899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.84899902 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.92399597 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.42399597 105.3219986 Tm [(five)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.77000427 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.26998901 105.3219986 Tm [(dif)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ferent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.66799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.16799927 120.92199707 Tm [(chromos)1(ome)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.29499817 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 144.2749939 0.75 l 144.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 145.2749939 -0.25 l 145.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 145.0249939 16.35000038 l h f* Q q 1 0 0 1 144.6499939 0 cm -0.625 -0.25 m 278.7250061 -0.25 l 278.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 144.2749939 0.75 l 144.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 145.2749939 -0.25 l 145.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 145.0249939 16.35000038 l h f* Q q 1 0 0 1 144.6499939 0 cm -0.625 -0.25 m 278.7250061 -0.25 l 278.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ATXN1\(Phos)1(pho-)1(Se)-1(r776)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.31400299 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 144.2749939 0.75 l 144.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 145.2749939 -0.25 l 145.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 145.0249939 16.35000038 l h f* Q q 1 0 0 1 144.6499939 0 cm -0.625 -0.25 m 278.7250061 -0.25 l 278.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(Se)-1(r)1(in)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.22200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.72198486 11.72200012 Tm [(77)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.6499939 0.75 m 144.6499939 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.6499939 126.30000305 m 144.6499939 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.6499939 142.65000916 m 144.6499939 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.6499939 159.00001526 m 144.6499939 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.375 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.375 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.375 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.125 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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