%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 159 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.74299622 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 132.41900635 23.67700005 Tm 0 Tr [(CSNK1)1(A1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 222.11599731 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 332.55599976 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CS)-1(N)1(K1A)1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.625 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.125 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.875 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CSNK)1(1A1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.10800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.48200226 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.13200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.5059967 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.06500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.43899536 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.23500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CK1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.18499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.55899811 12.82499981 Tm [(CK1a;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.14800262 12.82499981 Tm [(CKIa;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.68600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.05999756 12.82499981 Tm [(HLC)-1(DGP)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.25500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.6289978 12.82499981 Tm [(PRO29)1(75;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.80299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.17700195 12.82499981 Tm [(HEL)-1(-S-)-1(7)1(7p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.67401123 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(N)1(K1A)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.375 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 154.7749939 78.75 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Casein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.70800018 11.72200012 Tm [(Kinase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.60900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.10900116 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.75499725 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.25499725 11.72200012 Tm [(\(CK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.27200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.77200317 11.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.93000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.43000031 11.72200012 Tm [(CKI\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.81500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.31500244 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.87600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.37600708 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.3769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.8769989 11.72200012 Tm [(name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.43699646 11.72200012 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.96499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.46499634 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.53999329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.03999329 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.01499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.51499939 11.72200012 Tm [(fa)1(mi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.15899992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.6590004 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.50099945 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.00099945 27.3220005 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.25500107 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.75500107 27.3220005 Tm [(consisting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.31400299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.81400299 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.65599823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.15599823 27.3220005 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.52799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.02799988 27.3220005 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.18800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.68800354 27.3220005 Tm [(\()] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 206.69400024 27.3220005 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 212.68800354 27.3220005 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.85499573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 219.35499573 27.3220005 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 225.34899902 27.3220005 Tm [(',)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.82299805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 234.32299805 27.3220005 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 239.73300171 27.3220005 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.8999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 246.3999939 27.3220005 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 251.4980011 27.3220005 Tm [(1-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.44399977 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 11.94400024 42.92200089 Tm [<0027>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 17.65200043 42.92200089 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.81900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.31900024 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.59600067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 45.09600067 42.92200089 Tm [<0029>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 49.38100052 42.92200089 Tm [(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.38700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.88700104 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.28299713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.78299713 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.75800323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.25800323 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.33500671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.83500671 42.92200089 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.68499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.18499756 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.272995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.772995 42.92200089 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.6000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.75200081 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.25200081 58.52199936 Tm [(var)1(i)-1(a)1(ble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.0059967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.5059967 58.52199936 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.05999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.55999756 58.52199936 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.40699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.90699768 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.1289978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.6289978 58.52199936 Tm [(determine)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.03500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.53500366 58.52199936 Tm [(subc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.24900055 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.74900055 74.12200165 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.55899811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.05899811 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.33599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.83599854 74.12200165 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.17700195 74.12200165 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.55799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.05799866 74.12200165 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.69599915 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CSNK1A1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.13299942 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(CSNK1A1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.9960022 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(casei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.70100021 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.20100021 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.28900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.78900146 11.72200012 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.23300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.73300171 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.36699677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.86699677 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14499664 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAADE 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<001C>] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CK1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.1779995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.6779995 11.72200012 Tm [(CK1a;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.83000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.33000183 11.72200012 Tm [(CKIa)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.84999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.34999847 11.72200012 Tm [(HL)-1(CD)1(GP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.4489975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.9489975 11.72200012 Tm [(PRO297)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.94299316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.44299316 11.72200012 Tm [(HEL-S-77)-1(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.2559967 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q /GS2 gs 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P48)-1(72)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 0.75 m 154.3999939 78.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 79.5 m 154.3999939 95.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 95.84999847 m 154.3999939 111.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 112.19999695 m 154.3999939 127.79999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 128.54998779 m 154.3999939 144.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 144.8999939 m 154.3999939 160.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 161.25 m 154.3999939 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 177.2250061 m 423.17498779 177.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>