%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 158 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 9.74600029 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 59.42200089 23.67700005 Tm 0 Tr [(CSNK1)1(A1\(Pho)1(sph)1(o-Tyr294\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.20199585 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 317.20199585 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.60600281 54.8769989 Tm [<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 218.69400024 54.8769989 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 78 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CS)-1(N)1(K1A)1(1\(Pho)-1(spho)-1(-Tyr2)1(94\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.73300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 196.98300171 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 249.48300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.73300171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 111.53900146 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CSNK)1(1A1\(P)1(h)-1(osp)-1(ho-)-1(Tyr)1(294\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.34100342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.71499634 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.36500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.73899841 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.29800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.67199707 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.46798706 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 145.07800293 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CK1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.18499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.55899811 12.82499981 Tm [(CK1a;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.14800262 12.82499981 Tm [(CKIa;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.68600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.05999756 12.82499981 Tm [(HLC)-1(DGP)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.25500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.6289978 12.82499981 Tm [(PRO29)1(75;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.80299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.17700195 12.82499981 Tm [(HEL)-1(-S-)-1(7)1(7p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.67401123 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 178.61700439 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 279.23400879 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(N)1(K1A)1(1\(Pho)-1(spho)-1(-Tyr2)1(94\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 312.77301025 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 346.31201172 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 413.39001465 m 416.75 413.39001465 l 416.75 444.59002686 l -1.45000005 444.59002686 l h f* Q q 1 0 0 1 0 413.39001465 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 444.58999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 472.5289917 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.375 0.75 l 422.375 94.34999847 l 154.0249939 94.34999847 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7250061 -0.25 l 269.7250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Casein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.70800018 11.72200012 Tm [(ki)-1(na)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.9620018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46199799 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.48000336 11.72200012 Tm [(op)1(e)-1(ra)1(tionally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.01100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.51100159 11.72200012 Tm [(defined)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.29899597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.79899597 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.31100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.81100464 11.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.64399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.14399719 11.72200012 Tm [(preferen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.11800003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.61800003 27.3220005 Tm [(utilizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.11800003 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.61799622 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.45999908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.95999908 27.3220005 Tm [(acidic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.50800323 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.00800323 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.48100281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.98100281 27.3220005 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.7480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.2480011 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.38900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.88900757 27.3220005 Tm [(casei)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.7559967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.2559967 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.39700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.89700317 27.3220005 Tm [(subst)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(e)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.7670002 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.2670002 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.26600075 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.76599884 42.92200089 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.79999924 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.29999924 42.92200089 Tm [(ph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.51799774 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.01799774 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.49299622 42.92200089 Tm [(larg)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.16200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.66200256 42.92200089 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.47799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.97799683 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.82000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.32000732 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.95899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.45899963 42.92200089 Tm [(Pa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(rt)1(i)-1(cipa)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.44100189 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.94100189 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.88199997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.38199997 58.52199936 Tm [(Wnt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.43900299 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.93900299 58.52199936 Tm [(signaling.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.03700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.53700256 58.52199936 Tm [(Pho)1(spho)1(ryl)-1(a)1(tes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.67900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.17900085 58.52199936 Tm [(CTNNB)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.91700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.41700745 58.52199936 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.74499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.24499512 58.52199936 Tm [('S)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(er-45)-1('.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.4659996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.9659996 74.12200165 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.4980011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.9980011 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.8789978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.3789978 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.35399628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.85399628 74.12200165 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.51399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.01399994 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.95500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.45500183 74.12200165 Tm [(segregat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.80900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.30900574 74.12200165 Tm [(chromos)1(ome)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.27000427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.77000427 74.12200165 Tm [(duri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 89.72200012 Tm [(mito)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.59899902 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7250061 -0.25 l 269.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7250061 -0.25 l 269.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CSNK1A1\(Phos)1(pho-)1(Ty)-1(r294)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.1780014 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 154.0249939 16.35000038 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7250061 -0.25 l 269.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.92498779 11.72200012 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 0.75 m 153.6499939 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 95.09999847 m 153.6499939 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 111.44999695 m 153.6499939 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 127.79999542 m 153.6499939 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.375 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.375 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.375 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 143.7749939 m 423.125 143.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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