%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 127 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.6969986 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 141.3730011 23.67700005 Tm 0 Tr [(CSMD1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.16299438 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.60299683 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CS)-1(MD1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.43199921 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 172.93200684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.18200684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CSMD)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.91600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.29000092 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.94000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.31399536 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.8730011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.24699402 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.04299927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PP)1(P1R2)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.93900299 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(MD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.18199921 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 160.0249939 0.75 l 160.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 161.0249939 -0.25 l 161.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 160.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 160.7749939 172.3500061 l h f* Q q 1 0 0 1 160.3999939 0 cm -0.625 -0.25 m 263.0249939 -0.25 l 263.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CSMD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.14199829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.64199829 11.72200012 Tm [(CUB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.02899933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.52899933 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.80599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.30599976 11.72200012 Tm [(Sushi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.14900208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.64900208 11.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.02099609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.52099609 11.72200012 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.51400757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.01400757 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.29200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.79200745 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.35299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.85299683 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.82800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.32800293 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.63499451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.66300011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.1629982 27.3220005 Tm [(humans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.37000275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.87000275 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.43099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.93099976 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.43800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.93800354 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.44999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.94999695 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.95100403 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.45100403 27.3220005 Tm [(CSMD1gen)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.2749939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.7749939 27.3220005 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.77400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.27400208 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.83500671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.33500671 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.30999756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(po)1(ten)-1(t)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5929985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.0929985 42.92200089 Tm [(tumour)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.1289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.6289978 42.92200089 Tm [(supp)1(re)-1(ss)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.03700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.53700256 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.53799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.03799438 42.92200089 Tm [(dele)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.41799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.91799927 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.75999451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.25999451 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.35699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.85699463 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.02799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.00300026 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.50300026 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.44400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.94400024 58.52199936 Tm [(head)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.32300186 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.82299805 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.09999847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.59999847 58.52199936 Tm [(ne)-1(ck)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.66500092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.16500092 58.52199936 Tm [(carc)-1(inoma)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.83900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.33900452 58.52199936 Tm [(behav)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.1309967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.6309967 58.52199936 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.32899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.82899475 58.52199936 Tm [(ag)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ressivel)-1(y.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.42599869 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.92599869 74.12200165 Tm [(CSMD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.06800079 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.56800079 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.1289978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.6289978 74.12200165 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14099884 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.64099884 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.48300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.98300171 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.98399353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.48399353 74.12200165 Tm [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.83999634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.33999634 74.12200165 Tm [(system)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.32800293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.82800293 74.12200165 Tm [(th)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 89.72200012 Tm [(defends)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.41199875 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.91199875 89.72200012 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.07800293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.57800293 89.72200012 Tm [(pa)1(tho)1(gen)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.49200439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.99200439 89.72200012 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.88900757 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.38900757 89.72200012 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.32800293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.82800293 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.82899475 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.32899475 89.72200012 Tm [(cl)-1(a)1(ssic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.82200623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.46099854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.96099854 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.11899948 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.61899948 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.62000275 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.12000275 105.3219986 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.48500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.98500061 105.3219986 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.61300659 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.11300659 105.3219986 Tm [(Located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.15699768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.65699768 105.3219986 Tm [(prima)1(rily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.63499451 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.13499451 105.3219986 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 120.92199707 Tm [(ne)-1(r)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.96500015 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.46500015 120.92199707 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.3809967 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.8809967 120.92199707 Tm [(cone)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.10099792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.60099792 120.92199707 Tm [(CSMD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.74299622 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.24299622 120.92199707 Tm [(blocks)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.68699646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.18699646 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.18800354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.68800354 120.92199707 Tm [(cl)-1(a)1(ssic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.18099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.68099976 120.92199707 Tm [(pa)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(wa)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.84399986 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.34399986 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.18600082 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.68600082 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.68700027 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.18700027 136.52200317 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.64600372 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.14600372 136.52200317 Tm [(system)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.13400269 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.63400269 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.91099548 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.41099548 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.97200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.47200012 136.52200317 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.28500366 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.78500366 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.86000061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.36000061 136.52200317 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.21400452 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.71400452 136.52200317 Tm [(involv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 152.12199402 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.29399872 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.79399872 152.12199402 Tm [(supp)1(re)-1(ss)1(i)-1(o)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.70600128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.20600128 152.12199402 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.34700012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.84700012 152.12199402 Tm [(defec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.96899414 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.46899414 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.41000366 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.91000366 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.91099548 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.41099548 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.92700195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.42700195 152.12199402 Tm [(en)-1(cod)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 167.72200012 Tm [(CSMD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.94499969 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.44499969 167.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.96299744 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.46299744 167.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58999634 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.08999634 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.48599243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.98599243 167.72200012 Tm [(squa)1(mous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.29600525 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.79600525 167.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.20599365 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.70599365 167.72200012 Tm [(carci)-1(nom)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 160.3999939 0.75 m 160.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>