%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 19.20299911 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 68.8789978 23.67700005 Tm 0 Tr [(ATRIP\()1(P)-1(h)1(osp)1(ho-S)1(e)-1(r68\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.65600586 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 285.65600586 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 396.0960083 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(ATRIP)1(\()-1(P)1(h)-1(osp)-1(ho-S)-1(e)1(r68\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.17799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 177.42799377 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 229.92799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.17799377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(T)-1(R)1(IP\(Pho)-1(sph)-1(o-Ser68)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.78700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.16099548 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.81100464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.18499756 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.7440033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.11801147 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.91400146 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATRIP)1(\()-1(P)1(h)-1(osp)-1(ho-S)-1(e)1(r68\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.05299377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 94.34999847 l 161.5249939 94.34999847 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.71600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21600342 11.72200012 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.42399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.92399597 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.61300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.11300659 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.95500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.45500183 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.45599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.95599365 11.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.46099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(da)1(mage)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.0019989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.5019989 27.3220005 Tm [(che)-1(ckpoint.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.0059967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.5059967 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.31300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.81300354 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.32000732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.82000732 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.1269989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.6269989 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.23899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.73899841 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.81399536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.31399536 27.3220005 Tm [(singl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e-st)1(randed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.09600067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.59600067 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.10099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.60099792 42.92200089 Tm [(coat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.02700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.52700043 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.92300415 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.42300415 42.92200089 Tm [(replic)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.00700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.50700378 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.81399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.31399536 42.92200089 Tm [(A.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.81300354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.31300354 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.11999512 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.06399918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.56399918 58.52199936 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.40799713 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.90799713 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.30400085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.80400085 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.80499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.30499268 58.52199936 Tm [(at)1(axia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.53799438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.03799438 58.52199936 Tm [(telangiec)-1(t)1(asia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.04800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.54800415 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.82499695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(Rad)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.88500023 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.38500023 74.12200165 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.51399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.01399994 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.32099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.82099915 74.12200165 Tm [(ki)-1(na)1(se)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.07499695 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.57499695 74.12200165 Tm [(resulting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.27600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.77600098 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.71699524 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.21699524 74.12200165 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.1309967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.6309967 74.12200165 Tm [(acc)-1(umulatio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.37400055 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.87400055 89.72200012 Tm [(intra)1(n)-1(ucle)-1(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.09700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.59700012 89.72200012 Tm [(fo)1(c)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.34700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.84700012 89.72200012 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.46699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.96699524 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.47900391 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.97900391 89.72200012 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.48399353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.98399353 89.72200012 Tm [(da)1(mage.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.15299988 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ATRIP)1(\(Phosp)1(ho-)1(S)-1(er68)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66400146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 31.95000076 l 161.5249939 31.95000076 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Pept)1(i)-1(d)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.47200012 11.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.31900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.81900024 11.72200012 Tm [(aro)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30000305 11.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 11.72200012 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.09500122 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.93699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 11.72200012 Tm [(Se)-1(r)1(in)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.22200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(68)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 27.3220005 Tm [(\(L-A)1(-S\(p\)-)1(Q-A\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.21399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.71399689 27.3220005 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.4960022 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.20700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.70700073 27.3220005 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.16700745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.66700745 27.3220005 Tm [(ATRIP)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.35299683 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ATR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.36700058 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.86700058 11.72200012 Tm [(interacting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.24199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.74199677 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.0490036 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 191.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 161.5249939 0.75 m 422.375 0.75 l 422.375 16.35000038 l 161.5249939 16.35000038 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2250061 -0.25 l 262.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WXE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.80199814 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.1499939 0.75 m 161.1499939 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 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127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.375 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 175.7250061 m 422.375 175.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 192.07501221 m 422.375 192.07501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 208.42501831 m 423.125 208.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>