%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 161 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 82.28700256 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 131.96299744 23.67700005 Tm 0 Tr [(ATP6V1D)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 222.57299805 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 333.01300049 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(ATP6)1(V)-1(1D)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.92700195 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.42700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.42700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(T)-1(P)1(6V1D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.41100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.78500366 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80900574 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.36799622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.74200439 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.53799438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATPase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.97699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.35099792 12.82499981 Tm [(H+)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.12200165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.4960022 12.82499981 Tm [(transpo)-1(r)1(ti)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.42700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.80099487 12.82499981 Tm [(V1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.08000183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.45399475 12.82499981 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.55400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.92799377 12.82499981 Tm [(D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.19799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.57200623 12.82499981 Tm [(VATD)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.99099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.36500549 12.82499981 Tm [(VMA8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.50698853 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.88101196 12.82499981 Tm [(ATP6)1(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.79699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATP6)1(V)-1(1D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.67700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 153.2749939 0.75 l 153.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 154.2749939 -0.25 l 154.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 154.0249939 172.3500061 l h f* Q q 1 0 0 1 153.6499939 0 cm -0.625 -0.25 m 269.7749939 -0.25 l 269.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.35899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.85899353 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.70100403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.20100403 11.72200012 Tm [(vacuolar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.48699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.98699951 11.72200012 Tm [(ATPa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.23199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.73199463 11.72200012 Tm [(\(V-A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(TPase\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.08499908 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.58499908 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.06000137 27.3220005 Tm [(multisubunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.48200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.98200226 27.3220005 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.36300659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.86300659 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.08500671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.58500671 27.3220005 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.8769989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.3769989 27.3220005 Tm [(acidificatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.42999268 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.05199814 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.55199814 42.92200089 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.01899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.51899719 42.92200089 Tm [(org)1(ane)-1(lles.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.28999329 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.78999329 42.92200089 Tm [(V-A)1(T)-1(Pa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.01499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.51499939 42.92200089 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.54098511 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(org)1(ane)-1(lle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.43799973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.93799973 58.52199936 Tm [(acidificatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.99099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.49099731 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.05200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.55200195 58.52199936 Tm [(ne)-1(cessary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.33099365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.83099365 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.10899353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.60899353 58.52199936 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.37600708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.87600708 58.52199936 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.34300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.84300232 58.52199936 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rocesse)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.38199997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.88199997 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.02299881 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.52299881 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.83000183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.33000183 74.12200165 Tm [(sor)1(ting,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.87200165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.37200165 74.12200165 Tm [(zymog)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.125 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.625 74.12200165 Tm [(activat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.74200439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.24200439 74.12200165 Tm [(rec)-1(ept)1(or-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.88199997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.38199997 89.72200012 Tm [(en)-1(d)1(ocy)-1(t)1(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.75800323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.25800323 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.53500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.03500366 89.72200012 Tm [(synapt)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.4940033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.9940033 89.72200012 Tm [(vesic)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.3999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.8999939 89.72200012 Tm [(pro)1(ton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.42700195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.92700195 89.72200012 Tm [(gr)1(adie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 105.3219986 Tm [(gene)-1(r)1(ation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.50799942 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.00800323 105.3219986 Tm [(V-A)1(T)-1(Pa)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.23300171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.73300171 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.29399872 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.79399872 105.3219986 Tm [(composed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.96099854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.46099854 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.30299377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.80299377 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.77799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.27799988 105.3219986 Tm [(cy)-1(t)1(osolic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.82000732 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.32000732 105.3219986 Tm [(V1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.68400574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.18400574 105.3219986 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(oma)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06999969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56999969 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.84700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.34700012 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.3219986 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.8219986 120.92199707 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.08200073 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58200073 120.92199707 Tm [(V0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.94599915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.44599915 120.92199707 Tm [(do)1(main.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.44000244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.94000244 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.74699402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.24699402 120.92199707 Tm [(V1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.61099243 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.11099243 120.92199707 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.93798828 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(consists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.02700043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.52700043 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.36899948 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.86899948 136.52200317 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.41300201 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.91300201 136.52200317 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.2460022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.7460022 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.02300262 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.52300262 136.52200317 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.06700134 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.56700134 136.52200317 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.21400452 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.71400452 136.52200317 Tm [(subunits,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.34599304 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.84599304 136.52200317 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.0269928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.5269928 136.52200317 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.22000122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.72000122 136.52200317 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.18600464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(plus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.85499954 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.35499954 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.35599899 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.85599899 152.12199402 Tm [(C,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.04299927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.54299927 152.12199402 Tm [(D,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.56499863 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.06500244 152.12199402 Tm [(E,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18000031 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68000031 152.12199402 Tm [(F,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.62799835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.12799835 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.40499878 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.90499878 152.12199402 Tm [(H)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.86599731 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.36599731 152.12199402 Tm [(subunits.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.9980011 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.4980011 152.12199402 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.30499268 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.80499268 152.12199402 Tm [(V1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.16900635 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.66900635 152.12199402 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.4960022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.9960022 152.12199402 Tm [(cont)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.08200073 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58200073 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.58300018 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.08300018 167.72200012 Tm [(ATP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.08100128 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.58100128 167.72200012 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.81600189 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.31600189 167.72200012 Tm [(site.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.50299835 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.00299835 167.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.80999756 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.30999756 167.72200012 Tm [(V0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.67399597 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.17399597 167.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.00100708 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.50100708 167.72200012 Tm [(consists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.52799988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.02799988 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.86999512 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.36999512 167.72200012 Tm [(fiv)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.6499939 0.75 m 153.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>