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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.20500183 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 132.8809967 23.67700005 Tm 0 Tr [(ATP6AP1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 221.65400696 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 332.09399414 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(ATP6)1(AP1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.00999451 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.50999451 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 191.00999451 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(T)-1(P)1(6AP)1(1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 122.49299622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 124.86699677 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 150.51699829 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 152.89100647 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 196.44999695 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 198.82400513 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 236.61999512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATP6)1(AP1)1(;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 104.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 106.94300079 12.82499981 Tm [(16A)1(;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 126.47200012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 128.84599304 12.82499981 Tm [(ATP6)1(IP1;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 166.98500061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 169.35899353 12.82499981 Tm [(ATP6)1(S)-1(1;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 204.25300598 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 206.6269989 12.82499981 Tm [(Ac)1(45;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 230.59599304 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 232.97000122 12.82499981 Tm [(CF)-1(2;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 251.52400208 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 253.897995 12.82499981 Tm [(MGC1297)1(81;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 309.8380127 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 312.21200562 12.82499981 Tm [(VATPS1;)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 347.74200439 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 350.11599731 12.82499981 Tm [(XAP)1(-3;)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 378.4119873 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 380.78601074 12.82499981 Tm [(XAP)1(3)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 403.05700684 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATP6)1(AP1)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 101.76000214 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 90 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 96 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 97 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 99 >> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 148.0249939 0.75 l 148.0249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 149.0249939 -0.25 l 149.0249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 101 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.7749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 148.7749939 156.75 l h f* Q q 1 0 0 1 148.3999939 0 cm -0.625 -0.25 m 275.0249939 -0.25 l 275.0249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(component)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 147.35899353 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 151.85899353 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 160.70100403 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 165.20100403 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 170.17599487 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 174.67599487 11.72200012 Tm [(multisubunit)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 229.0980072 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 233.5980072 11.72200012 Tm [(en)-1(z)1(y)-1(m)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(\(1)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 17.88999939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 22.38999939 27.3220005 Tm [(mDa)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 42.65299988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 47.15299988 27.3220005 Tm [(MW\))] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 68.11100006 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 72.61100006 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 89.83300018 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 94.33300018 27.3220005 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 133.625 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 138.125 27.3220005 Tm [(acidificatio)1(n)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 190.17799377 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 194.67799377 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 203.52000427 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 208.02000427 27.3220005 Tm [(eu)-1(karyot)1(ic)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 252.72999573 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 257.23001099 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tr)1(ac)-1(ellul)-1(a)1(r)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 42.52600098 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 47.02600098 42.92200089 Tm [(org)1(ane)-1(lles.)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 93.79699707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 98.29699707 42.92200089 Tm [(Vacu)-1(o)1(l)-1(a)1(r)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 135.94500732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 140.44500732 42.92200089 Tm [(ATPa)1(se)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 171.69000244 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 176.19000244 42.92200089 Tm [(\(V-A)1(T)-1(Pa)1(se)-1(\))] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 223.42700195 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 227.92700195 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 234.48800659 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 238.98800659 42.92200089 Tm [(compr)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ised)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 17.42399979 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 21.92399979 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 30.76600075 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 35.26599884 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 40.24100113 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 44.74100113 58.52199936 Tm [(cy)-1(t)1(osolic)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 82.28299713 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 86.78299713 58.52199936 Tm [(V1)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 98.14700317 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 102.64700317 58.52199936 Tm [(\(site)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 120.67299652 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 125.17299652 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 134.01499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 138.51499939 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 152.51600647 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 157.01600647 58.52199936 Tm [(ATP)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 174.01400757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 178.51400757 58.52199936 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 213.74899292 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 218.24899292 58.52199936 Tm [(site\))] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 236.2749939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 240.7749939 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 257.05200195 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 261.55200195 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 266.52700806 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 68.26000214 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 72.76000214 74.12200165 Tm [(V0)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 84.12400055 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 88.62400055 74.12200165 Tm [(do)1(main.)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 123.61799622 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 128.11799622 74.12200165 Tm [(V-A)1(T)-1(Pa)1(se)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 169.34300232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 173.84300232 74.12200165 Tm [(dependen)-1(t)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 220.8690033 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 225.3690033 74.12200165 Tm [(org)1(ane)-1(lle)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 265.80700684 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(acidificatio)1(n)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 52.0530014 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 56.5530014 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 63.11399841 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 67.61399841 89.72200012 Tm [(ne)-1(cessary)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 109.39299774 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 113.89299774 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 126.17099762 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 130.67100525 89.72200012 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 150.43800354 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 154.93800354 89.72200012 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 205.40499878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 209.90499878 89.72200012 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 252.03500366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 256.53500366 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 265.67599487 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 31.30699921 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 35.80699921 105.3219986 Tm [(sor)1(ting,)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 68.34899902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 72.84899902 105.3219986 Tm [(zymog)1(e)-1(n)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 112.60199738 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 117.10199738 105.3219986 Tm [(activat)1(ion,)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 161.21899414 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 165.71899414 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 181.9960022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 186.4960022 105.3219986 Tm [(rec)-1(ept)1(or-)1(m)-1(edia)1(te)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(d)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(en)-1(d)1(ocy)-1(t)1(osis.)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 63.63299942 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 68.13300323 120.92199707 Tm [(The)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 83.94000244 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 88.44000244 120.92199707 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 125.9469986 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 130.44700623 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 161.7539978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 166.2539978 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 175.09599304 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 179.59599304 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 195.05200195 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 199.55200195 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 221.06799316 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 225.56799316 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 232.1289978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 236.6289978 120.92199707 Tm [(ap)1(prox)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(imat)1(e)-1(ly)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 31.42099953 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 35.92100143 136.52200317 Tm [(45)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 46.47700119 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 50.97700119 136.52200317 Tm [(kD)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 62.73199844 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 67.23200226 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 83.50900269 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 88.00900269 136.52200317 Tm [(may)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 106.18000031 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 110.68000031 136.52200317 Tm [(assist)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 133.90100098 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 138.40100098 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 146.34199524 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 150.84199524 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 164.84300232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 169.34300232 136.52200317 Tm [(V-A)1(T)-1(Pa)1(se)-1(-)1(me)-1(d)1(iated)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 255.34399414 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 259.84399414 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ci)-1(d)1(ific)-1(a)1(tion)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 47.07899857 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 51.57899857 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 60.42100143 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 64.92099762 152.12199402 Tm [(ne)-1(uro)1(e)-1(ndo)1(c)-1(rine)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 133.40499878 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 137.90499878 152.12199402 Tm [(sec)-1(reto)1(ry)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 177.50900269 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 182.00900269 152.12199402 Tm [(gr)1(anu)-1(les.)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 221.10299683 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 148.0249939 0.75 l 148.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.0249939 -0.25 l 149.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 264 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 265 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 148.7749939 16.35000038 l h f* Q q 1 0 0 1 148.3999939 0 cm -0.625 -0.25 m 275.0249939 -0.25 l 275.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 266 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.3999939 0.75 m 148.3999939 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.3999939 157.5 m 148.3999939 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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