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q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 5 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(CS)-1(F1R\(Pho)-1(spho)-1(-Tyr)1(708\))] TJ ET EMC /P <</MCID 8 >> BDC BT 1 0 0 -1 178.62800598 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 183.87800598 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 236.37800598 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 246.87800598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CSF)-1(1R\(P)1(h)-1(osp)-1(ho-)-1(Ty)1(r708\))] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 186.23699951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 188.61099243 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 214.26100159 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 216.63499451 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 260.19400024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 262.56799316 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 300.36401367 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FMS)-1(;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 84.43599701 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 86.80999756 12.82499981 Tm [(CS)-1(FR;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 110.56800079 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 112.94200134 12.82499981 Tm [(FIM2;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 137.52099609 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 139.89500427 12.82499981 Tm [(HDL)-1(S;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 164.94500732 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 167.31900024 12.82499981 Tm [(C-F)-1(MS;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 197.56799316 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 199.94200134 12.82499981 Tm [(CD115;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 230.7749939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 233.14900208 12.82499981 Tm [(CS)-1(F-1R;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 265.44400024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 267.81799316 12.82499981 Tm [(M-CS)-1(F-R)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 304.17300415 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0011000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(F1R\(Pho)-1(spho)-1(-Tyr)1(708\))] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 165.50300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F000D>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700220027000D>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 85 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 88 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 145.7749939 172.3500061 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 278.0249939 -0.25 l 278.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 184.16700745 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 188.66700745 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 225.08900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 229.58900452 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 241.86700439 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 246.36700439 11.72200012 Tm [(colo)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ny)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 10.31000042 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 14.81000042 27.3220005 Tm [(st)1(i)-1(mulat)1(in)-1(g)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 63.1230011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 67.6230011 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 92.74199677 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 97.24199677 27.3220005 Tm [(1,)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 104.68599701 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 109.18599701 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 114.16100311 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 118.66100311 27.3220005 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 154.96000671 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 159.46000671 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 184.55700684 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 189.05700684 27.3220005 Tm [(controls)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 223.91000366 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 228.41000366 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 242.41099548 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 246.91099548 27.3220005 Tm [(pro)1(d)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(uc)-1(t)1(ion,)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 29.24099922 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 33.74100113 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion,)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 97.23300171 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 101.73300171 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 118.01000214 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 122.51000214 42.92200089 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 158.25100708 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 162.75100708 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 171.59300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 176.09300232 42.92200089 Tm [(macrop)1(hages.)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 236.63200378 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 241.13200378 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 258.39401245 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 262.89401245 42.92200089 Tm [(r)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ec)-1(ept)1(or)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 32.98500061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 37.48500061 58.52199936 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 76.77700043 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 81.27700043 58.52199936 Tm [(most)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 102.9509964 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 107.4509964 58.52199936 Tm [(if)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 112.96600342 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 117.46600342 58.52199936 Tm [(not)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 132.08700562 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 136.58700562 58.52199936 Tm [(all)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 146.352005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 150.852005 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 159.69400024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 164.19400024 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 178.19500732 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 182.69500732 58.52199936 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 224.71099854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 229.21099854 58.52199936 Tm [(effec)-1(t)1(s)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 257.6960144 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 262.1960144 58.52199936 Tm [(o)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(f)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 3.11999989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 7.61999989 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 23.07600021 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 27.57600021 74.12200165 Tm [(cy)-1(t)1(oki)-1(ne.)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 66.04100037 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 70.54100037 74.12200165 Tm [(Ligand)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 99.58899689 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 104.08899689 74.12200165 Tm [(binding)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 137.23300171 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 141.73300171 74.12200165 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 179.29299927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 183.79299927 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 197.79400635 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 202.29400635 74.12200165 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 238.71600342 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 243.21600342 74.12200165 Tm [(ki)-1(na)1(s)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 5.10599995 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 9.60599995 89.72200012 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 44.50299835 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 49.00299835 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 53.97800064 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 58.47800064 89.72200012 Tm [(pro)1(c)-1(ess)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 91.33599854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 95.83599854 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 104.6780014 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 109.1780014 89.72200012 Tm [(oligo)1(me)-1(riz)1(ation)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 176.95500183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 181.45500183 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 197.73199463 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 202.23199463 89.72200012 Tm [(tr)1(anspho)1(spho)1(r)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ylation.)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 31.31500053 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 35.81499863 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 51.62200165 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 56.12200165 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 93.6289978 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 98.1289978 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 129.43600464 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 133.93600464 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 140.49699402 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 144.99699402 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 149.97200012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 154.47200012 105.3219986 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 188.96000671 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 193.46000671 105.3219986 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 220.54800415 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 225.04800415 105.3219986 Tm [(tr)1(ansme)-1(m)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(bra)1(ne)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 24.81200027 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 29.31200027 120.92199707 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 65.73400116 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 70.23400116 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 86.51100159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 91.01100159 120.92199707 Tm [(member)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 127.27500153 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 131.7749939 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 140.61700439 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 145.11700439 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 159.11799622 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 163.61799622 120.92199707 Tm [(CSF1)-1(/PDG)1(F)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 212.57299805 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 217.07299805 120.92199707 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 253.49499512 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 257.99499512 120.92199707 Tm [(fa)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(mily)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 17.98699951 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 22.48699951 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 31.32900047 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 35.82899857 136.52200317 Tm [(tyro)1(sin)-1(e-p)1(rot)1(e)-1(in)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 105.51699829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 110.01699829 136.52200317 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 143.43699646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 147.93699646 136.52200317 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 191.78599548 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 196.28599548 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 204.227005 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 208.727005 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 224.18299866 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 228.68299866 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 250.19900513 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 254.69900513 136.52200317 Tm [(ha)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ve)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 9.83100033 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 14.33100033 152.12199402 Tm [(been)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 35.83800125 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 40.33800125 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 85.46499634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 89.96499634 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 108.36100006 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 112.86100006 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 117.83599854 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 122.33599854 152.12199402 Tm [(predisp)1(ositio)1(n)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 183.99099731 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 188.49099731 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 197.56599426 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 202.06599426 152.12199402 Tm [(mye)-1(loid)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 236.63800049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 241.13800049 152.12199402 Tm [(malig)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nanc)-1(y.)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 27.51000023 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 32.00999832 167.72200012 Tm [(The)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 47.81700134 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 52.31700134 167.72200012 Tm [(first)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 68.78800201 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 73.28800201 167.72200012 Tm [(intro)1(n)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 99.28600311 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 103.78600311 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 112.62799835 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 117.12799835 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 132.58399963 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 137.08399963 167.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 158.6000061 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 163.1000061 167.72200012 Tm [(contains)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 199.31500244 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 203.81500244 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 208.78999329 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 213.28999329 167.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 0.75 m 145.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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