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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.90299988 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.57899475 23.67700005 Tm 0 Tr [(CRYGS)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.95599365 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.39599609 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(CRYGS)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.11499786 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.61500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.11500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CRYGS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.59799957 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.97200012 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.62199402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.9960022 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.55499268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.92900085 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.7250061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cr)1(ystal)-1(li)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.2519989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.62599945 12.82499981 Tm [(gamm)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.40299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.7769928 12.82499981 Tm [(S;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.41099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.78500366 12.82499981 Tm [(CRYG8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.95700073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.33099365 12.82499981 Tm [(CT)-1(R)1(C)-1(T20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.10600281 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CRYGS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.86499786 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 148.0249939 0.75 l 148.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 149.0249939 -0.25 l 149.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 148.7749939 172.3500061 l h f* Q q 1 0 0 1 148.3999939 0 cm -0.625 -0.25 m 275.0249939 -0.25 l 275.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Crysta)1(lli)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61100006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.11100006 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.62900162 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.1289978 11.72200012 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.7519989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.2519989 11.72200012 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.26800537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.76800537 11.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.94900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.44900513 11.72200012 Tm [(cl)-1(a)1(sses:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.60299683 11.72200012 Tm [(ta)1(xon-sp)1(e)-1(cific,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.27700806 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 27.3220005 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.48400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.98400116 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.26100159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.76100159 27.3220005 Tm [(ubiquito)1(us.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.10099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.60099792 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.40800476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.90800476 27.3220005 Tm [(lat)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.5269928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.0269928 27.3220005 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.24200439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.74200439 27.3220005 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.96099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.46099854 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.46200562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.96999931 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.46999931 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.94300079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.44300079 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.28500366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.78500366 42.92200089 Tm [(vertebra)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.12999725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.63000488 42.92200089 Tm [(ey)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.60699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.10699463 42.92200089 Tm [(len)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.32000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.82000732 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.09700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.59700012 42.92200089 Tm [(mainta)1(in)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.38000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.88000488 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.8809967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.38101196 42.92200089 Tm [(tr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(anspa)1(ren)-1(cy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.77500153 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.27500153 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.55200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05200195 58.52199936 Tm [(refra)1(c)-1(t)1(i)-1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.21800232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.71800232 58.52199936 Tm [(index)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.08399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.58399963 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.42599487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.92599487 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.92700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.42700195 58.52199936 Tm [(len)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.80700684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.30700684 58.52199936 Tm [(Sinc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.06199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.56199646 58.52199936 Tm [(len)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.7749939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.2749939 58.52199936 Tm [(ce)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.1590004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.6590004 74.12200165 Tm [(fib)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.46500015 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.96500015 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.54100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.04100037 74.12200165 Tm [(lose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.43000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.93000031 74.12200165 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.76300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.26300049 74.12200165 Tm [(nuc)-1(lei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.76400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.26400757 74.12200165 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.70100403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.20100403 74.12200165 Tm [(development,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.36500549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.86500549 74.12200165 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.13800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(cry)-1(s)1(tallins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.10400009 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.60400009 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.12200165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.62200165 89.72200012 Tm [(mad)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.89299774 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.39299774 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.66999817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.16999817 89.72200012 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.71699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.21699524 89.72200012 Tm [(retained)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.89199829 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.39199829 89.72200012 Tm [(th)1(rough)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.91000366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.41000366 89.72200012 Tm [(life,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.59300232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.09300232 89.72200012 Tm [(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.59799957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.09799957 105.3219986 Tm [(th)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.5320015 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.0320015 105.3219986 Tm [(extremel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.29399872 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.79399872 105.3219986 Tm [(st)1(able)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.53700256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.03700256 105.3219986 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.67599487 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.17599487 105.3219986 Tm [(Mammalian)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.09500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.59500122 105.3219986 Tm [(len)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.80799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.30799866 105.3219986 Tm [(cry)-1(s)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(allins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.87199974 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.37199974 120.92199707 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.88999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.38999939 120.92199707 Tm [(divid)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.28099823 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.78099823 120.92199707 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.79699707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.29699707 120.92199707 Tm [(alph)1(a,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.09700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.59700012 120.92199707 Tm [(beta)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.94599915 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.44599915 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.7230072 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.2230072 120.92199707 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.79499817 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.29499817 120.92199707 Tm [(fa)1(mi)-1(lies;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.44700623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.94700623 120.92199707 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.32800007 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.10499954 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.60499954 136.52200317 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.17700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.67700195 136.52200317 Tm [(cry)-1(s)1(tallins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.78099823 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.28099823 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.79899597 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.29899597 136.52200317 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.55599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.05599976 136.52200317 Tm [(considere)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.56100464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.06100464 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.20199585 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.70199585 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.67700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.17700195 136.52200317 Tm [(superfa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(mily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.15299988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.65299988 152.12199402 Tm [(Alp)1(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.64500046 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.14500046 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.42199707 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.92199707 152.12199402 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.10399628 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.60399628 152.12199402 Tm [(fa)1(mi)-1(lies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.58900452 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.08900452 152.12199402 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.60699463 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.10699463 152.12199402 Tm [(furt)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.64700317 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.14700317 152.12199402 Tm [(divid)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.03799438 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.53799438 152.12199402 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.55400085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.05400085 152.12199402 Tm [(acidi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.51300001 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.01299953 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.29000092 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.79000092 167.72200012 Tm [(ba)1(sic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.5870018 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.0870018 167.72200012 Tm [(gr)1(oups.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.6289978 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.1289978 167.72200012 Tm [(Se)-1(v)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.80599976 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.30599976 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.61300659 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.11300659 167.72200012 Tm [(regions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.24099731 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.74099731 167.72200012 Tm [(exist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.32299805 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.82299805 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.76400757 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.26400757 167.72200012 Tm [(cry)-1(s)1(talli)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.3999939 0.75 m 148.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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6 0 obj
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