%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 162 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 110 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(CRYAB)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 116.2990036 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 226.73899841 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 237.73899841 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -57.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -47 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -23.375 61.9640007 Tm [(CRYAB)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 7.45300293 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 59.95300293 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.20300293 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CRYAB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.93699646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.31099701 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.96099854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.33500671 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.26800537 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.06399536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CRYA2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6230011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.99700165 12.82499981 Tm [(CT)-1(P)1(P2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.69200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.06599426 12.82499981 Tm [(HS)-1(P)1(B5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.69999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.07400513 12.82499981 Tm [(CMD1II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.7230072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CRYAB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.20300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 160.7749939 0.75 l 160.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 161.7749939 -0.25 l 161.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 161.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 161.5249939 172.3500061 l h f* Q q 1 0 0 1 161.1499939 0 cm -0.625 -0.25 m 262.2749939 -0.25 l 262.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Crysta)1(lli)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61100006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.11100006 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.62900162 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.1289978 11.72200012 Tm [(separa)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.7519989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.2519989 11.72200012 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.26800537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.76800537 11.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.94900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.44900513 11.72200012 Tm [(cl)-1(a)1(sses:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.60299683 11.72200012 Tm [(ta)1(xon-sp)1(e)-1(cific,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.15799999 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.65799999 27.3220005 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.20500183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.70500183 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.98200226 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.48200226 27.3220005 Tm [(ubiquito)1(us.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.8219986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.3219986 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.1289978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.6289978 27.3220005 Tm [(lat)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.7480011 27.3220005 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.96299744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.46299744 27.3220005 Tm [(constitut)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.68200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 42.92200089 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.47100067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.97100067 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.44400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.94400024 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.78600311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.28600311 42.92200089 Tm [(vertebra)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.6309967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.1309967 42.92200089 Tm [(ey)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.10800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.60800171 42.92200089 Tm [(len)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.82099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.32099915 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.5980072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.0980072 42.92200089 Tm [(mainta)1(in)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.8809967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 58.52199936 Tm [(tr)1(anspar)1(e)-1(nc)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.06500244 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.56500244 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.84200287 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.34200287 58.52199936 Tm [(refra)1(c)-1(t)1(i)-1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.50799561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.00799561 58.52199936 Tm [(index)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.37399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.87399292 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.71600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.21600342 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.21699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.71699524 58.52199936 Tm [(len)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.09700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.59700012 58.52199936 Tm [(Sinc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.352005 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(len)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.21299934 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.71299934 74.12200165 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.0379982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.5379982 74.12200165 Tm [(fib)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.34400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.84400177 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.41999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.91999817 74.12200165 Tm [(lose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.30899811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.80899811 74.12200165 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.64199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.14199829 74.12200165 Tm [(nuc)-1(lei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.64300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.14300537 74.12200165 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.58000183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.08000183 74.12200165 Tm [(develop)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(men)-1(t)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.60499954 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.10499954 89.72200012 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.37799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.87799835 89.72200012 Tm [(cry)-1(s)1(tallins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98200226 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.48200226 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.5 89.72200012 Tm [(mad)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.77099609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.27099609 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.54800415 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.04800415 89.72200012 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.59500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.09500122 89.72200012 Tm [(retained)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.77000427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.27000427 89.72200012 Tm [(th)1(ro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ugho)1(u)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.46500015 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.96500015 105.3219986 Tm [(life,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.14799881 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.64799881 105.3219986 Tm [(makin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.15299988 105.3219986 Tm [(th)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.58699799 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.08699799 105.3219986 Tm [(extremel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.34899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.84899902 105.3219986 Tm [(st)1(able)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.59199524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.09199524 105.3219986 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.73100281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.23100281 105.3219986 Tm [(Ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mmalian)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.15100098 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.65100098 120.92199707 Tm [(len)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.86399841 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.36399841 120.92199707 Tm [(cry)-1(s)1(tallins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.46800232 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.96800232 120.92199707 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.48600006 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.98600006 120.92199707 Tm [(divid)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.8769989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.3769989 120.92199707 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.39300537 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.89300537 120.92199707 Tm [(alph)1(a,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.69299316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.19299316 120.92199707 Tm [(beta)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.54200745 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.04200745 120.92199707 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 136.52200317 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.82899857 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.32899857 136.52200317 Tm [(fa)1(mi)-1(lies;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.48100281 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.98100281 136.52200317 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.16300201 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.66300201 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.94000244 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.44000244 136.52200317 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.01199341 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.51199341 136.52200317 Tm [(cry)-1(s)1(tallins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.61599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.11599731 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.63400269 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.13400269 136.52200317 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.39100647 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(considere)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.50500107 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.00500107 152.12199402 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.14599991 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.64600372 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.6210022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.1210022 152.12199402 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.37200165 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.87199402 152.12199402 Tm [(Alp)1(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.86399841 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.36399841 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.64100647 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.14100647 152.12199402 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.32299805 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.82299805 152.12199402 Tm [(fa)1(mi)-1(lies)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.80799866 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.30799866 152.12199402 Tm [(ar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 167.72200012 Tm [(furt)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.14599991 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.64599991 167.72200012 Tm [(divid)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.53700256 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.03700256 167.72200012 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.0530014 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.5530014 167.72200012 Tm [(acidic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.10099792 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.60099792 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.87800598 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.37800598 167.72200012 Tm [(ba)1(sic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.17500305 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.67500305 167.72200012 Tm [(gr)1(oups.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.21699524 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.71699524 167.72200012 Tm [(Se)-1(v)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.39399719 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.89399719 167.72200012 Tm [(pr)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.1499939 0.75 m 161.1499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>