%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 144 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.36599731 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.04200745 23.67700005 Tm 0 Tr [(ATP5D)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.49299622 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.93301392 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(ATP5)1(D)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 107.14800262 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.647995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.147995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(T)-1(P)1(5D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.13200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.5059967 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.15600586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.52999878 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.08900452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.46299744 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.25900269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ATP5)1(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.39800262 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0011000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001A000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B001C001D001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700210027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 136.7749939 0.75 l 136.7749939 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 137.7749939 -0.25 l 137.7749939 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.5249939 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 137.5249939 203.55000305 l h f* Q q 1 0 0 1 137.1499939 0 cm -0.625 -0.25 m 286.2749939 -0.25 l 286.2749939 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.54299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.04299927 11.72200012 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.82700348 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.32700348 11.72200012 Tm [(ATP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.32499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82499695 11.72200012 Tm [(syntha)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.44200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.94200134 11.72200012 Tm [(\(F1)-1(F0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.06599426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.56599426 11.72200012 Tm [(ATP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.06399536 11.72200012 Tm [(syntha)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.18099976 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 27.3220005 Tm [(Comp)1(le)-1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.92300034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.42300034 27.3220005 Tm [(V\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.51499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.01499939 27.3220005 Tm [(pro)1(duc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.01000214 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.51000214 27.3220005 Tm [(ATP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.50800323 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.00799561 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.71899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.21899414 27.3220005 Tm [(AD)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.91299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.41299438 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.35400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.85400391 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.85499573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.35499573 27.3220005 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.08399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.58399963 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.42599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.92599487 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.90100098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(ton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.52700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.02700043 42.92200089 Tm [(gr)1(adien)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.35199738 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.85199738 42.92200089 Tm [(across)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.83000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.33000183 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.33100128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.83100128 42.92200089 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.61500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.11500549 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.21200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.71200562 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.272995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.772995 42.92200089 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.91598511 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.41598511 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.92800903 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ele)-1(ctro)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.1780014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.6780014 58.52199936 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.41300201 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.91300201 58.52199936 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.66400146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.16400146 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.0059967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.5059967 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.50700378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.00700378 58.52199936 Tm [(respira)1(tory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.54499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.04499817 58.52199936 Tm [(chain.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.18200684 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.68200684 58.52199936 Tm [(F-t)1(y)-1(p)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.32800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ATPa)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.4109993 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.9109993 74.12200165 Tm [(consist)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.77200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.27200317 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.11399841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.61399841 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.79499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.29499817 74.12200165 Tm [(st)1(ruc)-1(tura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.01499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.51499939 74.12200165 Tm [(do)1(mains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.67500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.17500305 74.12200165 Tm [(F1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.23399353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.73399353 74.12200165 Tm [(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.62800598 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.12800598 74.12200165 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.875 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.375 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 89.72200012 Tm [(extra)1(me)-1(mb)1(rane)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.79799652 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.29799652 89.72200012 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.53300476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.03300476 89.72200012 Tm [(core,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.977005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.477005 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.7539978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.2539978 89.72200012 Tm [(F0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.31300354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.81300354 89.72200012 Tm [(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.70700073 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.20700073 89.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.95401001 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.45401001 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.45498657 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.7840004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.2840004 105.3219986 Tm [(pro)1(ton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.81099701 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.31099701 105.3219986 Tm [(channe)-1(l,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.09999847 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.59999847 105.3219986 Tm [(link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.69900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.19900513 105.3219986 Tm [(to)1(gether)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57400513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.07400513 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.58599854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.08599854 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.06100464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.56100464 105.3219986 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.88600159 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.38598633 105.3219986 Tm [(st)1(alk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.17498779 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.75200081 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.25200081 120.92199707 Tm [(periph)1(e)-1(ra)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.13999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.63999939 120.92199707 Tm [(st)1(alk)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.59500122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.09500122 120.92199707 Tm [(During)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.6309967 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.1309967 120.92199707 Tm [(cata)1(l)-1(ysis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.99899292 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.49899292 120.92199707 Tm [(ATP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.49699402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.99699402 120.92199707 Tm [(turnov)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.86700439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.36700439 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.30799866 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.80801392 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.80899048 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(cata)1(l)-1(yt)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.23500061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.73500061 136.52200317 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.56199646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.06199646 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.90399933 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.40399933 136.52200317 Tm [(F1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.46299744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.96299744 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.52400208 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.02400208 136.52200317 Tm [(couple)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.81100464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.31100464 136.52200317 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.40499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.90499878 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.88000488 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.38000488 136.52200317 Tm [(rot)1(ary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.06599426 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.56599426 136.52200317 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.67498779 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.17498779 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.01699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 152.12199402 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.82600021 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.32600021 152.12199402 Tm [(st)1(alk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.11499786 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.61499786 152.12199402 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.08100128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.58100128 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.65599823 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.15600586 152.12199402 Tm [(pro)1(ton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.68299866 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.18299866 152.12199402 Tm [(tr)1(ansloc)-1(a)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.44599915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.94599915 152.12199402 Tm [(Par)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.21699524 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.71699524 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.55899048 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.05899048 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.05999756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.47900009 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97900009 167.72200012 Tm [(F1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.0379982 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.5379982 167.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.36499786 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.86499786 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.14199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.64199829 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.48400116 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.98400116 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.98500061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.48500061 167.72200012 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.80999756 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.30999756 167.72200012 Tm [(st)1(alk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.09899902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.59899902 167.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.69599915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.19599915 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75700378 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.25700378 167.72200012 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.76901245 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.26901245 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.11099243 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 183.32200623 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.97999954 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.47999954 183.32200623 Tm [(rot)1(ary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.16600037 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.66600037 183.32200623 Tm [(ele)-1(ment.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.8789978 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.3789978 183.32200623 Tm [(Rot)1(at)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.31900024 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.81900024 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.66099548 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.16099548 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.16200256 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.66200256 183.32200623 Tm [(ce)-1(ntr)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.98699951 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.48699951 183.32200623 Tm [(st)1(alk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.27600098 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.77600098 183.32200623 Tm [(ag)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.43499947 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.93499947 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.93600082 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.43600082 198.92199707 Tm [(surrounding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.28900146 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.78900146 198.92199707 Tm [(alph)1(a3beta3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.16099548 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.66099548 198.92199707 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.1269989 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.6269989 198.92199707 Tm [(leads)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.02600098 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.52600098 198.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.60099792 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.10099792 198.92199707 Tm [(hydro)1(ly)-1(s)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.1499939 0.75 m 137.1499939 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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