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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(CO)-1(RO1C)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 131.75700378 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 242.19700623 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 253.19700623 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -35.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -11.875 61.9640007 Tm [(CORO1C)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.875 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 79.375 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.625 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(CORO1C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.23200226 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.88200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.2559967 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.81500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.18899536 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.98500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HCRNN)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.71900177 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CORO1C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.125 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 167.5249939 0.75 l 167.5249939 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 168.5249939 -0.25 l 168.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 168.2749939 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 168.2749939 156.75 l h f* Q q 1 0 0 1 167.8999939 0 cm -0.625 -0.25 m 255.5249939 -0.25 l 255.5249939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.29100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.79100037 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.01600647 11.72200012 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.68899918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.18899918 27.3220005 Tm [(WD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.20299911 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.70300293 27.3220005 Tm [(repeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.59400177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.09400177 27.3220005 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.61199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.11199951 27.3220005 Tm [(minimally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.84199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.34199524 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.41900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.91900635 27.3220005 Tm [(regions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.04699707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(ap)1(prox)1(i)-1(ma)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.95300293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.45300293 42.92200089 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.00900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.50900269 42.92200089 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.57900238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.07900238 42.92200089 Tm [(acids)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.88499451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.38499451 42.92200089 Tm [(typically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.68600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.18600464 42.92200089 Tm [(bra)1(c)-1(ke)-1(t)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.08099365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.58099365 42.92200089 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 58.52199936 Tm [(gly-h)1(i)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.17599869 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.67599869 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.95299911 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.45299911 58.52199936 Tm [(tr)1(p-a)1(sp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.77300262 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.27300262 58.52199936 Tm [(\(GH-W)1(D\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.01199341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.51199341 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.60899353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.10899353 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.27999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.77999878 58.52199936 Tm [(fa)1(c)-1(ilitat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.36000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.86000061 58.52199936 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(orma)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.58200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.08200073 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.92399979 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.42399979 74.12200165 Tm [(heterot)1(rime)-1(r)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.75800323 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.25800323 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.41600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.91600037 74.12200165 Tm [(multipro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.34500122 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.84500122 74.12200165 Tm [(complexe)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.76300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(Membe)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.79000092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.29000092 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.13199997 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.63199997 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.08799744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.58799744 89.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66999817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16999817 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.68800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.18800354 89.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.55700684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.05700684 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.9980011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.4980011 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.4730072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.9730072 89.72200012 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.72599792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.22599792 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.06799316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.56799316 89.72200012 Tm [(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(llul)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.1420002 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.6420002 105.3219986 Tm [(pro)1(c)-1(esses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93900299 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.43900299 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.28900146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.78900146 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.19900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.69900513 105.3219986 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.99099731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.49099731 105.3219986 Tm [(pro)1(gression,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.85800171 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.35800171 105.3219986 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.59100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tr)1(ansduc)-1(t)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.47399902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.97399902 120.92199707 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.13500214 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.63500214 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.91200256 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.41200256 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.92799377 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.42799377 120.92199707 Tm [(regulat)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.82499695 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.32499695 120.92199707 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.67500305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.17500305 120.92199707 Tm [(tr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(anscript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.13199997 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.63199997 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.20200348 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.70200348 136.52200317 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.04399872 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.54399872 136.52200317 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.7250061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.2250061 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.16499329 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.66499329 136.52200317 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.82499695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.32499695 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.67199707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.50699997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.00699997 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.6969986 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.1969986 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.47499847 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.97499847 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.43099976 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.93099976 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.61299896 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 167.5249939 0.75 l 167.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 168.5249939 -0.25 l 168.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 168.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 168.2749939 16.35000038 l h f* Q q 1 0 0 1 167.8999939 0 cm -0.625 -0.25 m 255.5249939 -0.25 l 255.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.8999939 0.75 m 167.8999939 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.8999939 157.5 m 167.8999939 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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