%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 139 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 95.75700378 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.43299866 23.67700005 Tm 0 Tr [(ASCC2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.102005 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 319.54199219 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(ASCC2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.66899872 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.16900635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.66900635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(S)-1(CC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.15200043 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.52600098 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.17599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.55000305 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.10899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.48300171 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.27900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(p100;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.29199982 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.66600037 12.82499981 Tm [(ASC1p)-1(1)1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.96800232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ASCC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.41899872 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 157.7749939 0.75 l 157.7749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 158.7749939 -0.25 l 158.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.5249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 158.5249939 172.3500061 l h f* Q q 1 0 0 1 158.1499939 0 cm -0.625 -0.25 m 265.2749939 -0.25 l 265.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ASCC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.34600067 11.72200012 Tm [(\(activa)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.33699799 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.83699799 11.72200012 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.06999969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.56999969 11.72200012 Tm [(coin)-1(t)1(egrat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.88400269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.38400269 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.66200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.16200256 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.64100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.14100647 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.44099426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(2\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.44999981 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.94999981 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.20700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.70700073 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.52600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.02600098 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.16699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.66699982 27.3220005 Tm [(ASC1P10)-1(0,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.99899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.49899292 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.05999756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.55999756 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.53500366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.03500366 27.3220005 Tm [(75)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.86799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.36799622 27.3220005 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.43800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93800354 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.57800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.07800293 27.3220005 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.26799965 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.76799965 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.32899857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.82899857 42.92200089 Tm [(ubiquito)1(usly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.16100311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.66100311 42.92200089 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.81500244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.31500244 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.59199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.09199524 42.92200089 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.30700684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.80700684 42.92200089 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.18099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.68099976 42.92200089 Tm [(CUE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.3690033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(do)1(main.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.99399948 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.49399948 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.30099869 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.80099869 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.31700134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.81700134 58.52199936 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.15899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.65899658 58.52199936 Tm [(ASCC2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.00500488 58.52199936 Tm [(map)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.32699585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.82699585 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.9019928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.4019928 58.52199936 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.44299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.94299316 58.52199936 Tm [(chr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(omo)1(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.30400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.80400085 74.12200165 Tm [(22)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.52600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.02600098 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.1230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.6230011 74.12200165 Tm [(ho)1(u)-1(ses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.8710022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.3710022 74.12200165 Tm [(over)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.36000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.86000061 74.12200165 Tm [(50)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.69299316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.19299316 74.12200165 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.875 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.375 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.6519928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.1519928 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.71299744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.21299744 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.21400452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(sec)-1(o)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.80999947 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.31000137 89.72200012 Tm [(smallest)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.2990036 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.7990036 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.83999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.33999634 89.72200012 Tm [(chromos)1(ome)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.30099487 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.80099487 89.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.6499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.1499939 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.09100342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.59100342 89.72200012 Tm [(seve)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.71199989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.21199989 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.21300125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.71300125 105.3219986 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.39499664 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.89499664 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.11699677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.61699677 105.3219986 Tm [(map)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.77300262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.27300262 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.8480072 105.3219986 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.64300537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.14300537 105.3219986 Tm [(22)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.69900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.19900513 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.71699524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.21699524 105.3219986 Tm [(involv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.80500031 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.30500031 120.92199707 Tm [(development)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.30200195 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.80200195 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.64399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.14399719 120.92199707 Tm [(Phelan-McDermid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.39700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.89700317 120.92199707 Tm [(syndrome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.9940033 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(Neu)-1(r)1(ofibr)1(omato)1(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.75800323 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.25800323 136.52200317 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.22899628 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.72899628 136.52200317 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.17299652 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67299652 136.52200317 Tm [(autism)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.54100037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.04100037 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.31799316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.81799316 136.52200317 Tm [(schizop)1(hreni)-1(a)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.49499512 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.99499512 136.52200317 Tm [(Ad)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(dit)1(ionally)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.86199951 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.36199951 152.12199402 Tm [(tr)1(ansloc)-1(a)1(tions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.62400055 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.12400055 152.12199402 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.19599915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.69599915 152.12199402 Tm [(chromos)1(ome)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.65699768 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.15699768 152.12199402 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.43499756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.93499756 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.21200562 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.71200562 152.12199402 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 167.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9489994 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.44900131 167.72200012 Tm [(lead)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.68199921 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.18199921 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.25700378 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.75700378 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.75800323 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.25800323 167.72200012 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.96000671 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.46000671 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.30200195 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.80200195 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.80299377 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.30299377 167.72200012 Tm [(Phila)1(de)-1(lp)1(hia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.03300476 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.53300476 167.72200012 Tm [(Chro)1(m)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.1499939 0.75 m 158.1499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>