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g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(COPS8)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 117.3710022 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.8710022 12.82499981 Tm [(    )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 190.8710022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(COPS8)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 111.85500336 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 114.22899628 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 139.8789978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 142.25300598 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 185.81199646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 188.18600464 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 225.98199463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COP9)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 86.29699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 88.67099762 12.82499981 Tm [(si)-1(g)1(n)-1(alo)-1(some)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 141.8789978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 144.25300598 12.82499981 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 176.35299683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 178.727005 12.82499981 Tm [(8;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 186.85800171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 189.23199463 12.82499981 Tm [(COP9;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 215.33799744 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 217.71200562 12.82499981 Tm [(CS)-1(N)1(8;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 243.04400635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 245.41799927 12.82499981 Tm [(SGN8)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 268.96600342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COPS8)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 91.1210022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 82 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 88 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 89 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 91 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 172.0249939 0.75 l 172.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 173.0249939 -0.25 l 173.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 172.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 172.7749939 172.3500061 l h f* Q q 1 0 0 1 172.3999939 0 cm -0.625 -0.25 m 251.0249939 -0.25 l 251.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(one)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 186.53999329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 191.03999329 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 199.88200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 204.38200378 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 218.38299561 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 222.88299561 11.72200012 Tm [(eigh)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 3.35299993 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 7.85300016 27.3220005 Tm [(subunits)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 44.31900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 48.81900024 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 57.6609993 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 62.1609993 27.3220005 Tm [(COP9)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 86.30000305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 90.80000305 27.3220005 Tm [(signalo)1(some,)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 147.34899902 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 151.84899902 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 156.82400513 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 161.32400513 27.3220005 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 187.71800232 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 192.21800232 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 236.29499817 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 31.30699921 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 35.80699921 42.92200089 Tm [(complex)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 72.28600311 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 76.78600311 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 94.00800323 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 98.50800323 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 138.41499329 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 142.91499329 42.92200089 Tm [(as)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 152.05599976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 156.55599976 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 167.07699585 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 171.57699585 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 214.53799438 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 219.03799438 42.92200089 Tm [(regul)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(or)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 17.48600006 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 21.98600006 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 29.92700005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 34.42699814 58.52199936 Tm [(multiple)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 69.7990036 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 74.2990036 58.52199936 Tm [(signaling)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 113.23000336 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 117.73000336 58.52199936 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 160.52400208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 165.02400208 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 180.83099365 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 185.33099365 58.52199936 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 223.78799438 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 228.28799438 58.52199936 Tm [(an)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(d)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 45.9980011 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 50.4980011 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 59.34000015 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 63.84000015 74.12200165 Tm [(COP9)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 87.97899628 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 92.47899628 74.12200165 Tm [(signalo)1(some)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 146.86099243 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 151.36099243 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 157.92199707 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 162.42199707 74.12200165 Tm [(similar)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 190.61700439 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 195.11700439 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 204.19200134 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 208.69200134 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 225.91400146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 230.41400146 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 239.2559967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 14.0010004 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 18.50099945 89.72200012 Tm [(19)-1(S)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 34.25099945 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 38.75099945 89.72200012 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 83.24099731 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 87.74099731 89.72200012 Tm [(pa)1(rticle)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 119.66300201 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 124.16300201 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 133.00500488 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 137.50500488 89.72200012 Tm [(26)-1(S)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 153.25500488 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 157.75500488 89.72200012 Tm [(pro)1(teasome.)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 211.68899536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 216.18899536 89.72200012 Tm [(COP9)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 240.32800293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(signalo)1(some)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 54.38199997 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 58.88199997 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 73.56400299 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 78.06400299 105.3219986 Tm [(been)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 99.57099915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 104.07099915 105.3219986 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 132.1519928 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 136.6519928 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 145.727005 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 150.227005 105.3219986 Tm [(interact)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 182.90499878 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 187.40499878 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 205.80099487 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 210.30099487 105.3219986 Tm [(SCF-ty)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(pe)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 10.85400009 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 15.35400009 120.92199707 Tm [(E3)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 25.57999992 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 30.07999992 120.92199707 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 68.76100159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 73.26100159 120.92199707 Tm [(ligases)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 102.22100067 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 106.72100067 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 122.9980011 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 127.4980011 120.92199707 Tm [(act)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 140.33900452 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 144.83900452 120.92199707 Tm [(as)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 153.97999573 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 158.47999573 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 163.45500183 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 167.95500183 120.92199707 Tm [(po)1(sitive)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 201.56399536 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 206.06399536 120.92199707 Tm [(regulat)1(o)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(r)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 3.43700004 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 7.9369998 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 16.77899933 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 21.27899933 136.52200317 Tm [(E3)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 31.50499916 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 36.00500107 136.52200317 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 74.68599701 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 79.18599701 136.52200317 Tm [(ligases.)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 110.31199646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 114.81199646 136.52200317 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 168.69299316 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 173.19299316 136.52200317 Tm [(splice)-1(d)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 203.27400208 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 207.77400208 136.52200317 Tm [(tr)1(ansc)-1(ri)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(pt)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 9.10099983 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 13.60099983 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 47.17100143 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 51.67100143 152.12199402 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 92.01300049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 96.51300049 152.12199402 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 127.99099731 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 132.49099731 152.12199402 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 169.65100098 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 174.15100098 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 194.4980011 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 198.9980011 152.12199402 Tm [(been)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 220.50500488 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 225.00500488 152.12199402 Tm [(ob)1(s)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(erve)-1(d)1(.)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 26.29700089 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 172.3999939 0.75 m 172.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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