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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 94.95200348 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.62800598 23.67700005 Tm 0 Tr [(CO)-1(PS)1(2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 209.90800476 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 320.34799194 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(COPS2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.8710022 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.3710022 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 164.6210022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(COPS2)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 111.85500336 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 114.22899628 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 139.8789978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 142.25300598 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 185.81199646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 188.18600464 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 225.98199463 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(N)1(2;)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 88.33200073 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 90.70600128 12.82499981 Tm [(SGN2;)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 117.06400299 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 119.43800354 12.82499981 Tm [(ALIEN;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 147.28799438 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 149.66200256 12.82499981 Tm [(TRIP15)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 179.19299316 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COPS2)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 91.1210022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 77 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 146.5249939 0.75 l 146.5249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 147.5249939 -0.25 l 147.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 147.2749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 147.2749939 172.3500061 l h f* Q q 1 0 0 1 146.8999939 0 cm -0.625 -0.25 m 276.5249939 -0.25 l 276.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Essential)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 37.04999924 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 41.54999924 11.72200012 Tm [(component)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 91.23899841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 95.73899841 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 104.58100128 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 109.08100128 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 123.08200073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 127.58200073 11.72200012 Tm [(COP9)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 151.72099304 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 156.22099304 11.72200012 Tm [(signalo)1(some)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 210.60299683 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 215.10299683 11.72200012 Tm [(complex)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 251.58200073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 256.08200073 11.72200012 Tm [(\(C)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(SN\),)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 17.68400002 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 22.18400002 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 27.1590004 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 31.6590004 27.3220005 Tm [(complex)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 68.13800049 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 72.63800049 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 109.00700378 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 113.50700378 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 121.44799805 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 125.94799805 27.3220005 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 156.91200256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 161.41200256 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 192.17399597 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 196.67399597 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 212.95100403 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 217.45100403 27.3220005 Tm [(developme)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ntal)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 16.2689991 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 20.7689991 42.92200089 Tm [(pro)1(c)-1(esses.)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 65.06600189 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 69.56600189 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 85.3730011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 89.8730011 42.92200089 Tm [(CSN)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 108.40499878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 112.90499878 42.92200089 Tm [(complex)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 149.38400269 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 153.88400269 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 160.44500732 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 164.94500732 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 175.46600342 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 179.96600342 42.92200089 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 217.17399597 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 221.67399597 42.92200089 Tm [(regulat)1(or)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 261.40100098 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 8.84200001 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 13.34200001 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 27.34300041 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 31.84300041 58.52199936 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 70.52400208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 75.02400208 58.52199936 Tm [(\(Ub)1(l\))] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 95.89800262 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 100.39800262 58.52199936 Tm [(conj)-1(ug)1(ation)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 151.87600708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 156.37600708 58.52199936 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 192.83700562 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 197.33700562 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 207.84899902 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 212.34899902 58.52199936 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 256.06600952 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 260.56600952 58.52199936 Tm [(t)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(he)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 10.64799976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 15.14799976 74.12200165 Tm [(dene)-1(d)1(dylatio)1(n)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 77.3259964 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 81.8259964 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 90.66799927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 95.16799927 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 109.16899872 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 113.66899872 74.12200165 Tm [(cu)-1(llin)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 136.45899963 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 140.95899963 74.12200165 Tm [(subunits)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 177.42500305 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 181.92500305 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 190.76699829 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 195.26699829 74.12200165 Tm [(SCF-typ)1(e)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 234.12800598 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 238.62800598 74.12200165 Tm [(E3)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 248.85400391 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 253.35400391 74.12200165 Tm [(lig)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ase)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 14.24699974 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 18.74699974 89.72200012 Tm [(complexe)-1(s)1(,)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 66.66500092 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 71.16500092 89.72200012 Tm [(leading)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 103.09600067 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 107.59600067 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 116.67099762 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 121.17099762 89.72200012 Tm [(decre)-1(a)1(se)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 159.33799744 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 163.83799744 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 177.83900452 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 182.33900452 89.72200012 Tm [(Ub)1(l)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 197.20100403 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 201.70100403 89.72200012 Tm [(ligas)1(e)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 226.49499512 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 230.99499512 89.72200012 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 261.4670105 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 8.84200001 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 13.34200001 105.3219986 Tm [(SCF-typ)1(e)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 52.20299911 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 56.70299911 105.3219986 Tm [(complexe)-1(s)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 102.45400238 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 106.95400238 105.3219986 Tm [(suc)-1(h)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 126.72100067 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 131.22099304 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 140.36199951 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 144.86199951 105.3219986 Tm [(SCF,)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 163.0249939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 167.5249939 105.3219986 Tm [(CSA)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 185.07200623 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 189.57200623 105.3219986 Tm [(or)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 198.72999573 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 203.22999573 105.3219986 Tm [(DD)1(B)-1(2.)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 230.03199768 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 234.53199768 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 250.33900452 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 254.83900452 105.3219986 Tm [(co)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mplex)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 26.24399948 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 30.74399948 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 37.30500031 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 41.80500031 120.92199707 Tm [(also)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 59.06200027 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 63.56200027 120.92199707 Tm [(involved)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 99.93099976 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 104.43099976 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 112.37200165 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 116.87200165 120.92199707 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 187.64599609 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 192.14599609 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 200.98800659 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 205.48800659 120.92199707 Tm [(p53)-1(/TP53)-1(,)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 249.0249939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 253.5249939 120.92199707 Tm [(c-j)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(un/)-1(JU)1(N,)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 34.70399857 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 39.20399857 136.52200317 Tm [(Ikapp)1(aB)-1(a)1(lpha/NFKBIA,)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 135.92300415 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 140.42300415 136.52200317 Tm [(ITPK1)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 164.7250061 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 169.2250061 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 185.5019989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 190.0019989 136.52200317 Tm [(IRF8/)-1(ICSBP,)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 239.60699463 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 244.10699463 136.52200317 Tm [(po)1(ssi)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(bly)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 12.90699959 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 17.40699959 152.12199402 Tm [(via)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 29.50099945 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 34.00099945 152.12199402 Tm [(its)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 43.91500092 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 48.41500092 152.12199402 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 96.34200287 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 100.84200287 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 119.23799896 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 123.73799896 152.12199402 Tm [(CK2)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 140.74899292 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 145.24899292 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 161.52600098 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 166.02600098 152.12199402 Tm [(PKD)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 184.10099792 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 188.60099792 152.12199402 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 222.02099609 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 226.52099609 152.12199402 Tm [(CSN-d)1(e)-1(p)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(en)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 30.41500092 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 34.91500092 167.72200012 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 105.68900299 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 110.18900299 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 119.03099823 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 123.53099823 167.72200012 Tm [(TP53)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 144.7519989 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 149.2519989 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 165.52900696 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 170.02900696 167.72200012 Tm [(JUN)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 187.6289978 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 192.1289978 167.72200012 Tm [(pro)1(motes)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 233.81599426 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 238.31599426 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 254.59300232 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 259.09298706 167.72200012 Tm [(pr)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.8999939 0.75 m 146.8999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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