%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 131 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 110 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(ASB)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 102.38800049 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 212.82800293 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -57.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -33.875 61.9640007 Tm [(ASB2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -9.31700134 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 43.18299866 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(Anti-)-1(A)1(S)-1(B2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.41699982 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.79100037 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.44099426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.81500244 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.37399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.7480011 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.54400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.91799927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.25 12.82499981 Tm [(ASB-2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.39800262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.77200317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(ASB2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.68299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.18299866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.44100189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.94100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.86199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.23600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.21800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.59199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.83999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.33999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.23899841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.73899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.25 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.90000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.27400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.83299255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.33299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 2.16100001 m 42.16799927 2.16100001 l 42.16799927 15.77799988 l 0 15.77799988 l h f* Q EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr 0.13333334 g 0.30000001 w 0.13333334 G [<0026>-4<0027>-4<0028>-4<0029>] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 412.46798706 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 440.40701294 cm q 1 g 0.375 0.75 m 183.2749939 0.75 l 183.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 184.2749939 -0.25 l 184.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 184.0249939 0.75 m 426.17498779 0.75 l 426.17498779 172.3500061 l 184.0249939 172.3500061 l h f* Q q 1 0 0 1 183.6499939 0 cm -0.625 -0.25 m 243.5249939 -0.25 l 243.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(anky)-1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.83900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.33900452 11.72200012 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.06399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 27.3220005 Tm [(SOCS)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.52099991 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.02099991 27.3220005 Tm [(bo)1(x-containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.69300079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.19300079 27.3220005 Tm [(\(ASB\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3789978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.8789978 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.18600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.68600464 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.93400574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.43400574 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.24499893 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.74499893 42.92200089 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.62599945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.12599945 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.10099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.60099792 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.26100159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.76100159 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.70200348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.20200348 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.50900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.00900269 42.92200089 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.78700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.28700256 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.79899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.29899597 42.92200089 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(oupling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.10800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.60800171 58.52199936 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.84899902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.34899902 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.19100189 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.69100189 58.52199936 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.99000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.49000549 58.52199936 Tm [(signalling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.81599426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.31599426 58.52199936 Tm [(\(SOCS\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.07099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.57099915 58.52199936 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ot)1(e)-1(ins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.28800011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.78800011 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.18399811 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.68399811 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.68499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.18499756 74.12200165 Tm [(elongin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.15200043 74.12200165 Tm [(BC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.81900024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.31900024 74.12200165 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.96499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.46499634 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.27200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.77200317 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.27900696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.36800003 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.86800003 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.8429985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3429985 89.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.64299774 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.14299774 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.98500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.48500061 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.45999908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.95999908 89.72200012 Tm [(multimeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.96600342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.46600342 89.72200012 Tm [(E3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.69200134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.19200134 89.72200012 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.8730011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.3730011 89.72200012 Tm [(lig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.24699974 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.74699974 105.3219986 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.22600174 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.72600174 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.94799805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.44799805 105.3219986 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.73999786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.23999786 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.24099731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.74099731 105.3219986 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.51899719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.01899719 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.86099243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.36099243 105.3219986 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.03699875 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.53699875 120.92199707 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.1760025 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.6760025 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.93800354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.43800354 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.95400238 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.45399475 120.92199707 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.50100708 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.00100708 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.97599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.47599792 120.92199707 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.13600159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.63600159 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.57699585 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.07699585 120.92199707 Tm [(retinoic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.54400635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(acid-induce)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.15299988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.65299988 136.52200317 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.56900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.06900024 136.52200317 Tm [(inhibitio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.10499573 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.60499573 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.88200378 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.38200378 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.70799255 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.20799255 136.52200317 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 152.12199402 Tm [(mye)-1(loid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.19200134 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.69200134 152.12199402 Tm [(leu)-1(ke)-1(mia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.54799652 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.04799652 152.12199402 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.79000092 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.29000092 152.12199402 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.17100525 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.67100525 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.7519989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.2519989 152.12199402 Tm [(tr)1(ansc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.93299961 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.43300056 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.00299835 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.50299835 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84500122 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.34500122 167.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.71699524 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.21699524 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.3769989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.8769989 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.22399902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.72399902 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.23100281 167.72200012 Tm [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 183.6499939 0.75 m 183.6499939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 426.92498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>