%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<</Author(\376\377\000A\000d\000m\000i\000n\000i\000s\000t\000r\000a\000t\000o\000r)/Creator(Aspose Ltd.)/Producer(Aspose.PDF for .NET 19.2)/CreationDate(D:20200603080200Z)/ModDate(D:20200731144750+08'00')>>
endobj
2 0 obj
<</Type/Catalog/Pages 3 0 R/Lang(en-US)/StructTreeRoot 43 0 R/MarkInfo<</Marked true>>/Metadata 140 0 R>>
endobj
3 0 obj
<</Type/Pages/Count 3/Kids[4 0 R 35 0 R 39 0 R]>>
endobj
4 0 obj
<</Type/Page/Parent 3 0 R/Contents 5 0 R/MediaBox[0 0 595.29998779 841.90002441]/Resources<</Font<</FAAAAH 7 0 R/FAAABB 11 0 R/FAAABG 16 0 R/FAAABJ 19 0 R/FAAACF 25 0 R/FAAACJ 29 0 R/FAAADC 32 0 R>>/ExtGState<</GS1 18 0 R/GS2 23 0 R>>/XObject<</X1 9 0 R>>>>/Group<</Type/Group/S/Transparency/CS/DeviceRGB>>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<</Length 24675>>stream
1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.20001221 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 100.15100098 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 149.82699585 23.67700005 Tm 0 Tr [(CO)-1(P1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 204.70899963 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 315.14898682 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(COP1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.04699707 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 154.54699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 159.79699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(COP1)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 107.02999878 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 109.40399933 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 135.05400085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 137.42799377 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 180.98699951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 183.36099243 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 221.15699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COP1)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 86.29699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 88.67099762 12.82499981 Tm [(E3)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 99.12000275 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 101.4940033 12.82499981 Tm [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 139.82299805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 142.19700623 12.82499981 Tm [(li)-1(gase)1(;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 169.1289978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 171.50300598 12.82499981 Tm [(RFWD2;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 205.96099854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 208.33500671 12.82499981 Tm [(RN)1(F)-1(200)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 241.60400391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0014000D>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COP1)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 86.29699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0016000D>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 83 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 86 >> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 147.2749939 0.75 l 147.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 148.2749939 -0.25 l 148.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 148.0249939 172.3500061 l h f* Q q 1 0 0 1 147.6499939 0 cm -0.625 -0.25 m 275.7749939 -0.25 l 275.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(E3)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 10.22599983 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 14.72599983 11.72200012 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 88.60700226 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 93.10700226 11.72200012 Tm [(ligase)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 117.90100098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 122.40100098 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 139.6230011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 144.1230011 11.72200012 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 183.41499329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 187.91499329 11.72200012 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 248.58599854 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 253.08599854 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(d)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 5.75699997 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 10.25699997 27.3220005 Tm [(subsequen)-1(t)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 60.29800034 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 64.79799652 27.3220005 Tm [(pro)1(teasoma)1(l)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 118.82900238 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 123.32900238 27.3220005 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 176.10699463 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 180.60699463 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 189.44900513 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 193.94900513 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 219.92900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 224.42900085 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 262.06799316 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(E3)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 10.22599983 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 14.72599983 42.92200089 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 53.4070015 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 57.9070015 42.92200089 Tm [(ligas)1(e)-1(s)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 86.86699677 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 91.36699677 42.92200089 Tm [(acc)-1(ept)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 119.57499695 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 124.07499695 42.92200089 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 162.7559967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 167.2559967 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 187.96699524 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 192.46699524 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 202.98800659 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 207.48800659 42.92200089 Tm [(E2)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 217.71400452 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 222.21400452 42.92200089 Tm [(ubiquitin-)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(conj)-1(ug)1(ating)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 51.51300049 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 56.01300049 58.52199936 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 89.39399719 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 93.89399719 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 101.83499908 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 106.33499908 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 120.33599854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 124.83599854 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 145.54699707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 150.04699707 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 158.88900757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 163.38900757 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 168.36399841 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 172.86399841 58.52199936 Tm [(th)1(ioe)-1(s)1(ter)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 211.04400635 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 215.54400635 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 231.82099915 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 236.32099915 58.52199936 Tm [(th)1(e)-1(n)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 255.86799622 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 260.36801147 58.52199936 Tm [(d)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(irec)-1(t)1(ly)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 25.96299934 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 30.46299934 74.12200165 Tm [(tr)1(ansfers)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 67.76799774 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 72.26799774 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 86.26899719 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 90.76899719 74.12200165 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 129.44999695 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 133.94999695 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 143.0249939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 147.5249939 74.12200165 Tm [(ta)1(rgeted)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 184.3690033 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 188.8690033 74.12200165 Tm [(subst)1(rat)1(e)-1(s.)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 235.05099487 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 239.55099487 74.12200165 Tm [(Involv)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ed)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 10.86299992 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 15.36299992 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 23.30400085 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 27.80400085 89.72200012 Tm [(JUN)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 45.40399933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 49.90399933 89.72200012 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 110.57499695 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 115.07499695 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 131.352005 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 135.852005 89.72200012 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 190.79699707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 195.29699707 89.72200012 Tm [(Direc)-1(t)1(ly)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 228.11500549 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 232.61500549 89.72200012 Tm [(involve)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(d)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 18.19799995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 22.69799995 105.3219986 Tm [(p53)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 39.0019989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 43.5019989 105.3219986 Tm [(\(TP53)-1(\))] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 70.73500061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 75.23500061 105.3219986 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 135.90600586 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 140.40600586 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 156.68299866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 161.18299866 105.3219986 Tm [(degra)1(dat)1(ion,)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 216.12800598 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 220.62800598 105.3219986 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 253.68400574 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 258.18399048 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(bo)1(l)-1(ish)1(in)-1(g)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 39.66500092 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 44.16500092 120.92199707 Tm [(p53)-1(-)1(dependen)-1(t)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 111.38800049 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 115.88800049 120.92199707 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 170.47200012 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 174.97200012 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 191.24899292 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 195.74899292 120.92199707 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 239.91000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 244.41000366 120.92199707 Tm [(Ub)1(iq)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(uitinates)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 36.83499908 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 41.33499908 136.52200317 Tm [(p53)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 57.63899994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 62.13899994 136.52200317 Tm [(indepen)-1(d)1(e)-1(nt)1(l)-1(y)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 124.26399994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 128.76400757 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 137.60600281 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 142.10600281 136.52200317 Tm [(MDM2)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 171.82600403 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 176.32600403 136.52200317 Tm [(or)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 185.48399353 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 189.98399353 136.52200317 Tm [(RCHY1.)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 221.71699524 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 226.21699524 136.52200317 Tm [(Pro)1(bab)1(l)-1(y)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 264.51098633 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 39.29199982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 43.79199982 152.12199402 Tm [(E3)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 54.01800156 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 58.51800156 152.12199402 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 97.1989975 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 101.6989975 152.12199402 Tm [(ligase)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 126.49299622 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 130.99299622 152.12199402 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 161.46499634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 165.96499634 152.12199402 Tm [(by)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 176.477005 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 180.977005 152.12199402 Tm [(func)-1(t)1(ionin)-1(g)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 230.41499329 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 234.91499329 152.12199402 Tm [(as)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 244.05599976 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 248.55599976 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 262.55700684 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 37.20800018 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 41.70800018 167.72200012 Tm [(RING)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 64.23899841 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 68.73899841 167.72200012 Tm [(do)1(main)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 101.56600189 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 106.06600189 167.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 138.36599731 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 142.86599731 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 151.70799255 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 156.20799255 167.72200012 Tm [(larg)1(e)-1(r)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 181.31399536 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 185.81399536 167.72200012 Tm [(E3)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 196.03999329 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 200.53999329 167.72200012 Tm [(complexe)-1(s)1(.)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 248.45799255 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 252.95799255 167.72200012 Tm [(In)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 261.14898682 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.6499939 0.75 m 147.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 131 0 R/Length 28904>>stream
<a href="http://www.qdhaiyan.cn/">ºÝºÝÈÈÔÚÏßÊÓƵÃâ·Ñ</a>
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<a href="http://<spider>" target="_blank"><Ö©Öë´Ê></a>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<script>
(function(){
    var bp = document.createElement('script');
    var curProtocol = window.location.protocol.split(':')[0];
    if (curProtocol === 'https') {
        bp.src = 'https://zz.bdstatic.com/linksubmit/push.js';
    }
    else {
        bp.src = 'http://push.zhanzhang.baidu.com/push.js';
    }
    var s = document.getElementsByTagName("script")[0];
    s.parentNode.insertBefore(bp, s);
})();
</script>
</body>