%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 152 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(ASAH)1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 117.26599884 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 227.70599365 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 238.70599365 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -35.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -11.875 61.9640007 Tm [(ASAH2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 19.58899689 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 72.08900452 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.33900452 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(A)1(S)-1(A)1(H2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.57299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.9469986 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.59700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.97099304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.52999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.90400696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.69999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HNA)1(C1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.125 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.49900055 12.82499981 Tm [(BCDas)-1(e)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.43899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.81300354 12.82499981 Tm [(LC)-1(Dase;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.45599365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.83000183 12.82499981 Tm [(NCDase;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.83700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.21099854 12.82499981 Tm [(N-CDase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.6230011 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ASAH2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.83899689 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 162.2749939 94.34999847 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Ceramida)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.5359993 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.0359993 11.72200012 Tm [(\(EC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.01100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.51100159 11.72200012 Tm [(3.5)-1(.)1(1)-1(.)1(2)-1(3\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5719986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.0719986 11.72200012 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.83900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.33900452 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.47999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.97999573 11.72200012 Tm [(ASA)1(H)-1(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.24499512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.74499512 11.72200012 Tm [(cata)1(l)-1(yze)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.25100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.75100708 11.72200012 Tm [(hydr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(olysis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.60700035 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.10700035 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.94900131 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.44900131 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.45000076 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.95000076 27.3220005 Tm [(N-a)1(c)-1(yl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.80699921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.30699921 27.3220005 Tm [(link)-1(ag)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.3809967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.8809967 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.7230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.2230072 27.3220005 Tm [(ce)-1(ra)1(mi)-1(d)1(e)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.11199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.61199951 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.58700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.08700562 27.3220005 Tm [(sec)-1(o)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.89700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.39700317 27.3220005 Tm [(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(senge)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.11800003 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.61800003 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.55899811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.05899811 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.0340004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.5340004 42.92200089 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.28700256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.78700256 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.6289978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.1289978 42.92200089 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.89100647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.39100647 42.92200089 Tm [(eve)-1(nt)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.55900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05900574 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.13400269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.63400269 42.92200089 Tm [(pro)1(duc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.46299744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.96299744 42.92200089 Tm [(sph)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(go)1(sin)-1(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.8579998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.35800171 58.52199936 Tm [(Sphingo)1(sine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 58.52199936 Tm [(exe)-1(r)1(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.70500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.20500183 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.56900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.06900024 58.52199936 Tm [(mito)1(gen)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.28900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.78900146 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.06599426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.56599426 58.52199936 Tm [(ap)1(opt)1(os)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(is-inducin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.9090004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.4090004 74.12200165 Tm [(activit)1(i)-1(es,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.9509964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.4509964 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.72799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.22799683 74.12200165 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.14199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.64199829 74.12200165 Tm [(ph)1(osph)1(orylated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.61700439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.11700439 74.12200165 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.82800293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.32800293 74.12200165 Tm [(func)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.82900047 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.32900047 89.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.46999931 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.97000122 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49100113 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.99100113 89.72200012 Tm [(intra)1(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.58999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.08999634 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.36699677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.86699677 89.72200012 Tm [(interc)-1(ellul)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.46600342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.96600342 89.72200012 Tm [(sec)-1(o)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.77600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.27600098 89.72200012 Tm [(messe)-1(ng)1(e)-1(r.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.26600647 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ASA)1(H)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.09799957 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 162.2749939 16.35000038 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(ASA)1(H)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.44400024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q 1 g 0.375 0.75 m 161.5249939 0.75 l 161.5249939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 162.5249939 -0.25 l 162.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 162.2749939 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 162.2749939 31.95000076 l h f* Q q 1 0 0 1 161.8999939 0 cm -0.625 -0.25 m 261.5249939 -0.25 l 261.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(N-a)1(c)-1(ylsphing)1(osine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.94499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.44499969 11.72200012 Tm [(amido)1(hydro)1(l)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.08900452 11.72200012 Tm [(\(non-lysoso)1(mal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.53900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.03900146 11.72200012 Tm [(ce)-1(ra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(midas)1(e)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.83800125 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.33800125 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61600113 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.34999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 0.75 m 161.8999939 94.34999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 95.09999847 m 161.8999939 110.69999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 111.44999695 m 161.8999939 127.04999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 127.79999542 m 161.8999939 143.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 161.8999939 144.1499939 m 161.8999939 175.34999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.34999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.72499084 m 423.17498779 175.72499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>