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[<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(COMT)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.39499664 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 157.89500427 12.82499981 Tm [(    )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 178.89500427 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(COMT)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 110.37799835 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 112.7519989 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 138.4019928 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 140.77600098 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 184.33500671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 186.70899963 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 224.50500488 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cate)1(ch)-1(ol-)-1(O-me)1(th)-1(y)1(l)-1(tr)1(an)-1(sfer)1(ase;)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 193.39399719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 195.76800537 12.82499981 Tm [(HEL)-1(-S-)-1(9)1(8n)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 239.26499939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(COMT)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 89.64499664 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 69 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 148.0249939 0.75 l 148.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 149.0249939 -0.25 l 149.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 73 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 148.7749939 172.3500061 l h f* Q q 1 0 0 1 148.3999939 0 cm -0.625 -0.25 m 275.0249939 -0.25 l 275.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 75 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cat)1(e)-1(chol-)1(O-methylt)1(ransferase)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 129.727005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 134.227005 11.72200012 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 172.89900208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 177.39900208 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 191.3999939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 195.8999939 11.72200012 Tm [(tr)1(ansfer)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 229.03900146 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 233.53900146 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 242.3809967 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 246.8809967 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 251.85600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 256.35598755 11.72200012 Tm [(m)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ethyl)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 21.15999985 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 25.65999985 27.3220005 Tm [(gr)1(oup)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 51.86899948 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 56.36899948 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 77.08000183 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 81.58000183 27.3220005 Tm [(S-a)1(de)-1(no)1(sy)-1(lmeth)1(i)-1(o)1(n)-1(ine)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 178.24200439 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 182.74200439 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 191.81700134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 196.31700134 27.3220005 Tm [(catec)-1(h)1(olamine)-1(s,)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 265.22299194 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 39.84999847 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 44.34999847 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 58.35100174 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 62.85100174 42.92200089 Tm [(ne)-1(uro)1(transmit)1(ters)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 139.92700195 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 144.42700195 42.92200089 Tm [(do)1(pamine)-1(,)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 190.2749939 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 194.7749939 42.92200089 Tm [(epine)-1(p)1(hrine)-1(,)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 248.61700439 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 253.11700439 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(norepine)-1(p)1(hrine.)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 78.8030014 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 83.3030014 58.52199936 Tm [(This)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 100.56500244 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 105.06500244 58.52199936 Tm [(O-meth)1(y)-1(la)1(tion)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 167.87600708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 172.37600708 58.52199936 Tm [(results)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 200.54499817 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 205.04499817 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 212.98599243 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 217.48599243 58.52199936 Tm [(one)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 233.86000061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 238.36000061 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 247.20199585 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 251.70199585 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 265.70300293 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(major)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 24.96999931 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 29.46999931 74.12200165 Tm [(degra)1(dat)1(ive)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 80.81099701 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 85.31099701 74.12200165 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 125.93800354 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 130.43800354 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 139.27999878 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 143.77999878 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 157.78100586 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 162.28100586 74.12200165 Tm [(catec)-1(h)1(olamine)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 224.85499573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 229.35499573 74.12200165 Tm [(tr)1(ansmit)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ters.)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 18.22900009 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 22.72900009 89.72200012 Tm [(In)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 30.92000008 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 35.41999817 89.72200012 Tm [(ad)1(dition)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 71.31900024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 75.81900024 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 84.89399719 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 89.39399719 89.72200012 Tm [(its)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 99.30799866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 103.80799866 89.72200012 Tm [(role)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 120.46800232 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 124.96800232 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 132.90899658 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 137.40899658 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 151.41000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 155.91000366 89.72200012 Tm [(metab)1(olism)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 206.63600159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 211.13600159 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 219.97799683 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 224.47799683 89.72200012 Tm [(en)-1(d)1(ogen)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ous)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 15.43400002 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 19.93400002 105.3219986 Tm [(subst)1(anc)-1(es,)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 69.38600159 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 73.88600159 105.3219986 Tm [(COMT)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 101.19400024 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 105.69400024 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 112.25499725 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 116.75499725 105.3219986 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 159.71600342 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 164.21600342 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 172.15699768 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 176.65699768 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 190.65800476 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 195.15800476 105.3219986 Tm [(metab)1(olism)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 245.88400269 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 250.38400269 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 259.22601318 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(catec)-1(h)1(ol)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 36.11899948 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 40.61899948 120.92199707 Tm [(dr)1(u)-1(g)1(s)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 65.28099823 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 69.78099823 120.92199707 Tm [(used)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 90.35600281 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 94.85600281 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 102.79699707 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 107.29699707 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 121.29799652 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 125.79799652 120.92199707 Tm [(tr)1(e)-1(at)1(men)-1(t)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 168.46000671 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 172.96000671 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 181.80200195 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 186.30200195 120.92199707 Tm [(hypert)1(e)-1(nsion,)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 244.89900208 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 249.39900208 120.92199707 Tm [(ast)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(hma)1(,)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 21.11599922 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 25.61599922 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 41.89300156 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 46.39300156 136.52200317 Tm [(Par)1(k)-1(inson)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 88.58499908 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 93.08499908 136.52200317 Tm [(disease.)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 126.92299652 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 131.42300415 136.52200317 Tm [(COMT)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 158.73100281 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 163.23100281 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 169.79200745 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 174.29200745 136.52200317 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 199.98199463 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 204.48199463 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 212.42300415 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 216.92300415 136.52200317 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 233.10400391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 237.60400391 136.52200317 Tm [(fo)1(rms)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 262.48098755 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 7.94099998 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 12.44099998 152.12199402 Tm [(tiss)1(u)-1(es,)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 43.50600052 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 48.00600052 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 52.98099899 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 57.48099899 152.12199402 Tm [(soluble)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 88.55899811 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 93.05899811 152.12199402 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 113.76999664 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 118.26999664 152.12199402 Tm [(\(S-COMT\))] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 160.67700195 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 165.17700195 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 181.45399475 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 185.95399475 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 190.92900085 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 195.42900085 152.12199402 Tm [(membrane-bo)1(u)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(nd)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 11.30300045 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 15.80300045 167.72200012 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 36.51399994 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 41.01399994 167.72200012 Tm [(\(MB-COMT\).)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 94.83399963 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 99.33399963 167.72200012 Tm [(The)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 115.14099884 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 119.64099884 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nce)-1(s)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 167.01400757 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 171.51400757 167.72200012 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 208.58599854 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 213.08599854 167.72200012 Tm [(S-COMT)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 249.48199463 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 253.98199463 167.72200012 Tm [(an)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.3999939 0.75 m 148.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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